Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIX5
  • Mouse genes Six5
  • Rat genes Six5
  • Zfish genes six5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Six5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Six5	IDA		Mouse	PMID:14966291
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Six5	IDA		Mouse	MGI:MGI:4836102|PMID:20696153
Molecular Function	GO:0005515	protein binding	SIX5	IPI	UniProtKB:P54253	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	Six5	IPI	RGD:1309932	Rat	PMID:10490620|RGD:1303343
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Six5	IDA		Mouse	MGI:MGI:82817|PMID:8814301
Molecular Function	GO:0043565	sequence-specific DNA binding	Six5	IDA		Mouse	PMID:8814301
Cellular Component	GO:0005829	cytosol	SIX5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	SIX5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	SIX5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SIX5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Six5	IDA		Mouse	PMID:8814301
Biological Process	GO:0008283	cell population proliferation	Six5	IMP	MGI:MGI:2148689	Mouse	PMID:15163633
Biological Process	GO:0002088	lens development in camera-type eye	Six5	IMP	MGI:MGI:2148689	Mouse	PMID:10802668
Biological Process	GO:0002088	lens development in camera-type eye	Six5	IMP	MGI:MGI:2148692	Mouse	PMID:10802667
Biological Process	GO:0160024	Leydig cell proliferation	Six5	IMP	MGI:MGI:2148689	Mouse	PMID:15163633
Biological Process	GO:0008285	negative regulation of cell population proliferation	Six5	IMP	MGI:MGI:2148689	Mouse	PMID:15163633
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Six5	IDA		Mouse	MGI:MGI:4836102|PMID:20696153
Biological Process	GO:1902723	negative regulation of skeletal muscle satellite cell proliferation	Six5	IMP		Mouse	MGI:MGI:4836102|PMID:20696153
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Six5	IDA		Mouse	MGI:MGI:4836102|PMID:20696153
Biological Process	GO:0007286	spermatid development	Six5	IMP	MGI:MGI:2148689	Mouse	PMID:15163633

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern