Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SKAP1
  • Mouse genes Skap1
  • Rat genes Skap1
  • Zfish genes skap1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Skap1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SKAP1	IPI	UniProtKB:O15117	Human	PMID:16461356
Molecular Function	GO:0005515	protein binding	SKAP1	IPI	UniProtKB:O15117	Human	PMID:19798671
Molecular Function	GO:0005515	protein binding	SKAP1	IPI	UniProtKB:P62952	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SKAP1	IPI	UniProtKB:Q5T9C2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SKAP1	IPI	UniProtKB:Q96QH2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SKAP1	IPI	UniProtKB:Q9H788	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SKAP1	IPI	UniProtKB:Q9H788-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SKAP1	IPI	UniProtKB:P46940	Human	PMID:26242911
Molecular Function	GO:0005515	protein binding	SKAP1	IPI	UniProtKB:Q15691	Human	PMID:26242911
Molecular Function	GO:0005515	protein binding	SKAP1	IPI	UniProtKB:O15117	Human	PMID:27335501
Molecular Function	GO:0005515	protein binding	SKAP1	IPI	UniProtKB:Q5VWT5	Human	PMID:27335501
Molecular Function	GO:0005515	protein binding	SKAP1	IPI	UniProtKB:Q5T9C2	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	SKAP1	IPI	UniProtKB:Q96QH2	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Skap1	IPI	PR:Q8R5A3	Mouse	PMID:17403904
Molecular Function	GO:0005515	protein binding	Skap1	IPI	PR:O35601	Mouse	PMID:17403904
Molecular Function	GO:0005515	protein binding	Skap1	IPI	UniProtKB:O35601,UniProtKB:P25911,UniProtKB:Q9QZE2	Rat	PMID:12681493|RGD:1299442
Molecular Function	GO:0019901	protein kinase binding	SKAP1	IPI	UniProtKB:P06241	Human	PMID:9195899
Molecular Function	GO:0019903	protein phosphatase binding	SKAP1	IPI	UniProtKB:P08575	Human	PMID:11909961
Molecular Function	GO:0044877	protein-containing complex binding	Skap1	IPI	RGD:1557394|RGD:1563421|RGD:621017	Rat	PMID:12681493|RGD:1299442
Molecular Function	GO:0042169	SH2 domain binding	SKAP1	IDA		Human	PMID:9195899
Molecular Function	GO:0042169	SH2 domain binding	Skap1	IPI	RGD:1557394	Rat	PMID:12681493|RGD:1299442
Cellular Component	GO:0005911	cell-cell junction	Skap1	IDA		Mouse	PMID:23793062
Cellular Component	GO:0005737	cytoplasm	SKAP1	IDA		Human	PMID:11909961
Cellular Component	GO:0005829	cytosol	SKAP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Skap1	IDA		Mouse	PMID:17403904
Cellular Component	GO:0001772	immunological synapse	SKAP1	IDA		Human	PMID:12652296
Cellular Component	GO:0005654	nucleoplasm	SKAP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SKAP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SKAP1	IDA		Human	PMID:11909961
Cellular Component	GO:0005886	plasma membrane	Skap1	IDA		Mouse	PMID:17403904
Cellular Component	GO:0044853	plasma membrane raft	SKAP1	IDA		Human	PMID:12652296
Cellular Component	GO:0032991	protein-containing complex	Skap1	IDA		Rat	PMID:12681493|RGD:1299442
Cellular Component	GO:0042101	T cell receptor complex	Skap1	IDA		Mouse	PMID:17403904
Biological Process	GO:0002821	positive regulation of adaptive immune response	SKAP1	IDA		Human	PMID:12652296
Biological Process	GO:0045785	positive regulation of cell adhesion	Skap1	IMP		Mouse	PMID:17403904
Biological Process	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin	SKAP1	IGI	UniProtKB:P11835,UniProtKB:P24063	Human	PMID:12652296
Biological Process	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin	SKAP1	IGI	UniProtKB:P22646,UniProtKB:P24063	Human	PMID:12652296
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	SKAP1	IGI	UniProtKB:P22646	Human	PMID:12652296
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	SKAP1	IMP		Human	PMID:11909961
Biological Process	GO:0034116	positive regulation of heterotypic cell-cell adhesion	SKAP1	IDA		Human	PMID:12652296
Biological Process	GO:0033625	positive regulation of integrin activation	SKAP1	IDA		Human	PMID:12652296
Biological Process	GO:1903039	positive regulation of leukocyte cell-cell adhesion	SKAP1	IDA		Human	PMID:12652296
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SKAP1	IDA		Human	PMID:11909961
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SKAP1	IMP		Human	PMID:11909961
Biological Process	GO:0072659	protein localization to plasma membrane	Skap1	IMP		Mouse	PMID:17403904
Biological Process	GO:0050852	T cell receptor signaling pathway	SKAP1	IMP		Human	PMID:11909961

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern