Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SKP2
  • Mouse genes Skp2
  • Rat genes Skp2
  • Zfish genes skp2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Skp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	SKP2	IPI	UniProtKB:Q13309	Human	PMID:22770219
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:Q13415	Human	PMID:11931757
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:Q13616	Human	PMID:12504026
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P63208	Human	PMID:12609982
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:Q13616	Human	PMID:12609982
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P61024	Human	PMID:12813041
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P63208	Human	PMID:12813041
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P46527	Human	PMID:16209941
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P61024	Human	PMID:16209941
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P28562	Human	PMID:16286470
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P38936	Human	PMID:16376880
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P63208	Human	PMID:16376880
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:Q4AE16	Human	PMID:16376880
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P19474	Human	PMID:16880511
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P01106	Human	PMID:17157259
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:A5D8W4	Human	PMID:18239684
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P61024	Human	PMID:18239684
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P62877	Human	PMID:18239684
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P63208	Human	PMID:18239684
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:Q13616	Human	PMID:18239684
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P46527	Human	PMID:18805092
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P63208	Human	PMID:18818696
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:Q96Q27	Human	PMID:21119685
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:Q13616	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P12004,UniProtKB:Q9H211	Human	PMID:21856198
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P46527	Human	PMID:22632967
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P63208	Human	PMID:22632967
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P09803	Human	PMID:22770219
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:Q09472	Human	PMID:22770219
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:Q9NTG7	Human	PMID:22770219
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:Q9UM11	Human	PMID:22770219
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P63208	Human	PMID:23911321
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P38936	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P27958	Human	PMID:27194766
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:Q13616	Human	PMID:27542266
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P63208	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P61024	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:Q13616	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P63208	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	SKP2	IPI	UniProtKB:P38936	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	Skp2	IPI	PR:O35129	Mouse	PMID:17785450
Molecular Function	GO:0005515	protein binding	Skp2	IPI	PR:Q9WTX5	Mouse	PMID:19398581
Molecular Function	GO:0005515	protein binding	Skp2	IPI	PR:P62878	Mouse	PMID:19398581
Molecular Function	GO:0005515	protein binding	Skp2	IPI	PR:Q9WTX6	Mouse	PMID:19398581
Molecular Function	GO:0005515	protein binding	Skp2	IPI	PR:P01108	Mouse	PMID:23277542
Molecular Function	GO:0005515	protein binding	Skp2	IPI	RGD:1359383	Rat	PMID:19533683|RGD:2315050
Molecular Function	GO:0005515	protein binding	Skp2	IPI	RGD:3541	Rat	PMID:19533683|RGD:2315050
Molecular Function	GO:0005515	protein binding	Skp2	IPI	RGD:69328	Rat	PMID:19533683|RGD:2315050
Molecular Function	GO:0005515	protein binding	Skp2	IPI	RGD:727892	Rat	PMID:19533683|RGD:2315050
Molecular Function	GO:0005515	protein binding	Skp2	IPI	RGD:69062	Rat	PMID:19852587|RGD:2315049
Cellular Component	GO:0005829	cytosol	SKP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	SKP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SKP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	SKP2	IDA		Human	PMID:16880511
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	Skp2	IDA		Mouse	PMID:17785450
Biological Process	GO:0071460	cellular response to cell-matrix adhesion	Skp2	IEP		Rat	PMID:11425869|RGD:2315071
Biological Process	GO:0051607	defense response to virus	SKP2	IMP		Human	PMID:27194766
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	Skp2	IDA		Mouse	PMID:10790373
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	Skp2	IMP		Mouse	PMID:19056892
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	Skp2	IGI	MGI:MGI:108061	Mouse	PMID:19056892
Biological Process	GO:0045087	innate immune response	SKP2	IMP		Human	PMID:27194766
Biological Process	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	Skp2	IGI	MGI:MGI:102520	Mouse	PMID:17785450
Biological Process	GO:1902916	positive regulation of protein polyubiquitination	Skp2	IDA		Mouse	PMID:23277542
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Skp2	IMP		Rat	PMID:19878790|RGD:2315048
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	SKP2	IMP		Human	PMID:27194766
Biological Process	GO:0070936	protein K48-linked ubiquitination	SKP2	IMP		Human	PMID:27194766
Biological Process	GO:0000209	protein polyubiquitination	Skp2	IDA		Mouse	PMID:17785450
Biological Process	GO:0042981	regulation of apoptotic process	SKP2	IDA		Human	PMID:23277542
Biological Process	GO:0051726	regulation of cell cycle	Skp2	IPI	PR:Q61457	Mouse	PMID:10790373
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Skp2	IDA		Mouse	PMID:10790373
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Skp2	IMP		Mouse	PMID:19056892

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern