Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC11A1
  • Mouse genes Slc11a1
  • Rat genes Slc11a1
  • Zfish genes slc11a2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc11a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005381	iron ion transmembrane transporter activity	slc11a2	IDA		Zfish	PMID:12393445
Molecular Function	GO:0005384	manganese ion transmembrane transporter activity	Slc11a1	IMP	MGI:MGI:2446573	Mouse	PMID:11067873
Molecular Function	GO:0051139	metal cation:proton antiporter activity	SLC11A1	IGI	UniProtKB:P38356	Human	PMID:17932044
Molecular Function	GO:0042803	protein homodimerization activity	SLC11A1	IDA		Human	PMID:8537108
Molecular Function	GO:0046915	transition metal ion transmembrane transporter activity	SLC11A1	IGI	UniProtKB:P38356	Human	PMID:17932044
Cellular Component	GO:0010008	endosome membrane	Slc11a1	IDA		Mouse	PMID:9034150
Cellular Component	GO:0005770	late endosome	Slc11a1	IMP		Mouse	PMID:9034150
Cellular Component	GO:0005770	late endosome	Slc11a1	IDA		Mouse	PMID:17620357
Cellular Component	GO:0005764	lysosome	Slc11a1	IDA		Mouse	PMID:17620357
Cellular Component	GO:0030670	phagocytic vesicle membrane	SLC11A1	IDA		Human	PMID:12070036
Cellular Component	GO:0030670	phagocytic vesicle membrane	Slc11a1	IDA		Mouse	PMID:9034150
Cellular Component	GO:0030670	phagocytic vesicle membrane	Slc11a1	IDA		Mouse	PMID:9271100
Cellular Component	GO:0030670	phagocytic vesicle membrane	Slc11a1	IMP	MGI:MGI:2446573	Mouse	PMID:11067873
Cellular Component	GO:0030670	phagocytic vesicle membrane	Slc11a1	IDA		Mouse	PMID:11067873
Cellular Component	GO:0005886	plasma membrane	SLC11A1	IMP		Human	PMID:17932044
Cellular Component	GO:0070821	tertiary granule membrane	SLC11A1	IDA		Human	PMID:12070036
Biological Process	GO:0032147	activation of protein kinase activity	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:8301134
Biological Process	GO:0048002	antigen processing and presentation of peptide antigen	Slc11a1	IMP	MGI:MGI:1857756	Mouse	PMID:17620357
Biological Process	GO:0070574	cadmium ion transmembrane transport	SLC11A1	IGI	UniProtKB:P38356	Human	PMID:17932044
Biological Process	GO:0098849	cellular detoxification of cadmium ion	SLC11A1	IGI	UniProtKB:P38356	Human	PMID:17932044
Biological Process	GO:0042742	defense response to bacterium	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:18285491
Biological Process	GO:0042742	defense response to bacterium	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:1541907
Biological Process	GO:0042742	defense response to bacterium	Slc11a1	IMP	MGI:MGI:1857756	Mouse	PMID:18285491
Biological Process	GO:0042742	defense response to bacterium	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:385184
Biological Process	GO:0042742	defense response to bacterium	Slc11a1	IMP	MGI:MGI:2446573	Mouse	PMID:7650477
Biological Process	GO:0042742	defense response to bacterium	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:18045875
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Slc11a1	IMP		Mouse	PMID:6358358
Biological Process	GO:0042832	defense response to protozoan	Slc11a1	IMP	MGI:MGI:1857756	Mouse	PMID:606434
Biological Process	GO:0042832	defense response to protozoan	Slc11a1	IMP		Mouse	PMID:8033407
Biological Process	GO:0042832	defense response to protozoan	Slc11a1	IMP	MGI:MGI:2446573	Mouse	PMID:7561513
Biological Process	GO:0035162	embryonic hemopoiesis	slc11a2	IMP	ZFIN:ZDB-GENO-980202-517	Zfish	PMID:9007251
Biological Process	GO:0051649	establishment of localization in cell	Slc11a1	IMP	MGI:MGI:2446573	Mouse	PMID:11067873
Biological Process	GO:0042541	hemoglobin biosynthetic process	slc11a2	IMP	ZFIN:ZDB-GENO-980202-517	Zfish	PMID:12393445
Biological Process	GO:0006954	inflammatory response	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:19116231
Biological Process	GO:0032623	interleukin-2 production	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:9176118
Biological Process	GO:0032632	interleukin-3 production	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:9176118
Biological Process	GO:0006879	intracellular iron ion homeostasis	SLC11A1	IMP		Human	PMID:16510578
Biological Process	GO:0006879	intracellular iron ion homeostasis	Slc11a1	IMP	MGI:MGI:2446573	Mouse	PMID:18456389
Biological Process	GO:0006879	intracellular iron ion homeostasis	Slc11a1	IMP		Mouse	PMID:11903051
Biological Process	GO:0006879	intracellular iron ion homeostasis	Slc11a1	IMP	MGI:MGI:2446573	Mouse	PMID:19321419
Biological Process	GO:0006826	iron ion transport	SLC11A1	IMP		Human	PMID:16510578
Biological Process	GO:1903826	L-arginine transmembrane transport	Slc11a1	IDA		Mouse	PMID:8529105
Biological Process	GO:0042116	macrophage activation	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:19116231
Biological Process	GO:0042116	macrophage activation	Slc11a1	IDA		Mouse	PMID:8529105
Biological Process	GO:0006828	manganese ion transport	Slc11a1	IMP	MGI:MGI:2446573	Mouse	PMID:11067873
Biological Process	GO:0030001	metal ion transport	Slc11a1	IDA		Mouse	MGI:MGI:4361983|PMID:17932044
Biological Process	GO:0045342	MHC class II biosynthetic process	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:8301134
Biological Process	GO:0048255	mRNA stabilization	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:9009318
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:9824471
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Slc11a1	IMP	MGI:MGI:2446573	Mouse	PMID:19321419
Biological Process	GO:0001818	negative regulation of cytokine production	Slc11a1	IMP	MGI:MGI:2446573	Mouse	PMID:16470178
Biological Process	GO:0015707	nitrite transport	Slc11a1	IDA		Mouse	PMID:8529105
Biological Process	GO:0006909	phagocytosis	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:18045875
Biological Process	GO:0001819	positive regulation of cytokine production	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:1541907
Biological Process	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	Slc11a1	IMP		Mouse	PMID:18984740
Biological Process	GO:0010628	positive regulation of gene expression	Slc11a1	IMP	MGI:MGI:2446573	Mouse	PMID:16470178
Biological Process	GO:0050766	positive regulation of phagocytosis	Slc11a1	IMP		Mouse	PMID:18984740
Biological Process	GO:0050766	positive regulation of phagocytosis	Slc11a1	IMP	MGI:MGI:2446573	Mouse	PMID:18456389
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	Slc11a1	IMP		Mouse	PMID:18984740
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Slc11a1	IMP	MGI:MGI:1857756	Mouse	PMID:17620357
Biological Process	GO:0032729	positive regulation of type II interferon production	Slc11a1	IMP		Mouse	PMID:18984740
Biological Process	GO:0045730	respiratory burst	Slc11a1	IDA		Mouse	PMID:8529105
Biological Process	GO:0009617	response to bacterium	SLC11A1	IDA		Human	PMID:7717395
Biological Process	GO:0009617	response to bacterium	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:8490962
Biological Process	GO:0046688	response to copper ion	slc11a2	IDA		Zfish	PMID:18987288
Biological Process	GO:0010039	response to iron ion	slc11a2	IDA		Zfish	PMID:18987288
Biological Process	GO:0032496	response to lipopolysaccharide	Slc11a1	IMP	MGI:MGI:1857756	Mouse	PMID:17620357
Biological Process	GO:0032496	response to lipopolysaccharide	Slc11a1	IDA		Mouse	PMID:9261342
Biological Process	GO:0032496	response to lipopolysaccharide	Slc11a1	IMP		Mouse	PMID:18984740
Biological Process	GO:0010038	response to metal ion	slc11a2	IDA		Zfish	PMID:18987288
Biological Process	GO:0034341	response to type II interferon	Slc11a1	IDA		Mouse	PMID:9261342
Biological Process	GO:0002369	T cell cytokine production	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:19116231
Biological Process	GO:0002309	T cell proliferation involved in immune response	Slc11a1	IMP	MGI:MGI:1857755	Mouse	PMID:9176118
Biological Process	GO:0032609	type II interferon production	Slc11a1	IMP		Mouse	PMID:18984740
Biological Process	GO:0007035	vacuolar acidification	Slc11a1	IMP		Mouse	PMID:11067873
Biological Process	GO:0007035	vacuolar acidification	Slc11a1	IMP	MGI:MGI:2446573	Mouse	PMID:9670047
Biological Process	GO:0007035	vacuolar acidification	Slc11a1	IMP		Mouse	PMID:18984740
Biological Process	GO:0042060	wound healing	Slc11a1	IMP	MGI:MGI:2446573	Mouse	PMID:16470178

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern