Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC11A2
  • Mouse genes Slc11a2
  • Rat genes Slc11a2
  • Zfish genes slc11a2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc11a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0046870	cadmium ion binding	SLC11A2	IDA		Human	PMID:25326704
Molecular Function	GO:0046870	cadmium ion binding	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857
Molecular Function	GO:0015086	cadmium ion transmembrane transporter activity	SLC11A2	IDA		Human	PMID:12662899
Molecular Function	GO:0015086	cadmium ion transmembrane transporter activity	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857
Molecular Function	GO:0050897	cobalt ion binding	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857
Molecular Function	GO:0015087	cobalt ion transmembrane transporter activity	Slc11a2	IDA		Mouse	PMID:12522007
Molecular Function	GO:0015087	cobalt ion transmembrane transporter activity	Slc11a2	IDA		Mouse	PMID:12724326
Molecular Function	GO:0015087	cobalt ion transmembrane transporter activity	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857
Molecular Function	GO:0005507	copper ion binding	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857
Molecular Function	GO:0005375	copper ion transmembrane transporter activity	SLC11A2	IDA		Human	PMID:12734107
Molecular Function	GO:0005375	copper ion transmembrane transporter activity	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857
Molecular Function	GO:0015093	ferrous iron transmembrane transporter activity	SLC11A2	IDA		Human	PMID:12734107
Molecular Function	GO:0015093	ferrous iron transmembrane transporter activity	SLC11A2	IDA		Human	PMID:17293870
Molecular Function	GO:0015093	ferrous iron transmembrane transporter activity	SLC11A2	IMP		Human	PMID:25491917
Molecular Function	GO:0015093	ferrous iron transmembrane transporter activity	Slc11a2	IMP		Rat	PMID:16091957|RGD:1580427
Molecular Function	GO:0005506	iron ion binding	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857
Molecular Function	GO:0005381	iron ion transmembrane transporter activity	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857
Molecular Function	GO:0005381	iron ion transmembrane transporter activity	slc11a2	IDA		Zfish	PMID:12393445
Molecular Function	GO:0015094	lead ion transmembrane transporter activity	SLC11A2	IDA		Human	PMID:12127992
Molecular Function	GO:0015094	lead ion transmembrane transporter activity	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857
Molecular Function	GO:0030145	manganese ion binding	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857
Molecular Function	GO:0005384	manganese ion transmembrane transporter activity	SLC11A2	IDA		Human	PMID:17293870
Molecular Function	GO:0005384	manganese ion transmembrane transporter activity	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857
Molecular Function	GO:0016151	nickel cation binding	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857
Molecular Function	GO:0015099	nickel cation transmembrane transporter activity	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857
Molecular Function	GO:0005515	protein binding	SLC11A2	IPI	UniProtKB:P02787	Human	PMID:15880641
Molecular Function	GO:0005515	protein binding	SLC11A2	IPI	UniProtKB:O00308	Human	PMID:18776082
Molecular Function	GO:0005515	protein binding	SLC11A2	IPI	UniProtKB:Q9BT67	Human	PMID:18776082
Molecular Function	GO:0005515	protein binding	SLC11A2	IPI	UniProtKB:Q9NV92	Human	PMID:18776082
Molecular Function	GO:0005515	protein binding	SLC11A2	IPI	UniProtKB:Q96PU5	Human	PMID:19706893
Molecular Function	GO:0005515	protein binding	SLC11A2	IPI	UniProtKB:Q9BT67	Human	PMID:19706893
Molecular Function	GO:0005515	protein binding	SLC11A2	IPI	UniProtKB:Q8N5I2	Human	PMID:27462458
Molecular Function	GO:0015295	solute:proton symporter activity	SLC11A2	IDA		Human	PMID:17109629
Molecular Function	GO:0046915	transition metal ion transmembrane transporter activity	SLC11A2	IDA		Human	PMID:25326704
Molecular Function	GO:0008270	zinc ion binding	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857
Cellular Component	GO:0045177	apical part of cell	SLC11A2	IDA		Human	PMID:15880641
Cellular Component	GO:0045177	apical part of cell	Slc11a2	IDA		Rat	PMID:18420243|RGD:2311408
Cellular Component	GO:0016324	apical plasma membrane	SLC11A2	IDA		Human	PMID:15880641
Cellular Component	GO:0045178	basal part of cell	SLC11A2	IDA		Human	PMID:15880641
Cellular Component	GO:0031526	brush border membrane	Slc11a2	IGI	UniProtKB:P20722	Mouse	MGI:MGI:4352622|PMID:19252488
Cellular Component	GO:0005737	cytoplasm	SLC11A2	IDA		Human	PMID:11891802
Cellular Component	GO:0005737	cytoplasm	Slc11a2	IDA		Rat	PMID:11891802|RGD:632962
Cellular Component	GO:0031410	cytoplasmic vesicle	SLC11A2	IDA		Human	PMID:15880641
Cellular Component	GO:0005769	early endosome	SLC11A2	IDA		Human	PMID:15880641
Cellular Component	GO:0005769	early endosome	SLC11A2	IDA		Human	PMID:25491917
Cellular Component	GO:0005768	endosome	Slc11a2	IDA		Mouse	PMID:16227996
Cellular Component	GO:1903561	extracellular vesicle	SLC11A2	IDA		Human	PMID:27462458
Cellular Component	GO:1903561	extracellular vesicle	Slc11a2	IDA		Mouse	MGI:MGI:5804712|PMID:27462458
Cellular Component	GO:0031902	late endosome membrane	SLC11A2	IDA		Human	PMID:10751401
Cellular Component	GO:0031902	late endosome membrane	Slc11a2	IDA		Rat	PMID:16449358|RGD:1580424
Cellular Component	GO:0005765	lysosomal membrane	SLC11A2	IDA		Human	PMID:10751401
Cellular Component	GO:0005765	lysosomal membrane	SLC11A2	HDA		Human	PMID:17897319
Cellular Component	GO:0005765	lysosomal membrane	Slc11a2	IDA		Rat	PMID:16449358|RGD:1580424
Cellular Component	GO:0016020	membrane	SLC11A2	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857
Cellular Component	GO:0005739	mitochondrion	SLC11A2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SLC11A2	IDA		Human	PMID:15880641
Cellular Component	GO:0070826	paraferritin complex	SLC11A2	IDA		Human	PMID:11842004
Cellular Component	GO:0048471	perinuclear region of cytoplasm	SLC11A2	IDA		Human	PMID:10751401
Cellular Component	GO:0005886	plasma membrane	SLC11A2	IMP		Human	PMID:11891802
Cellular Component	GO:0005886	plasma membrane	SLC11A2	IMP		Human	PMID:17932044
Cellular Component	GO:0005886	plasma membrane	SLC11A2	IMP		Human	PMID:25326704
Cellular Component	GO:0005886	plasma membrane	SLC11A2	IDA		Human	PMID:25491917
Cellular Component	GO:0005886	plasma membrane	Slc11a2	IDA		Mouse	MGI:MGI:5804712|PMID:27462458
Cellular Component	GO:0005886	plasma membrane	Slc11a2	IDA		Mouse	PMID:16227996
Cellular Component	GO:0055037	recycling endosome	SLC11A2	IDA		Human	PMID:15880641
Cellular Component	GO:0005773	vacuole	SLC11A2	IMP		Human	PMID:17932044
Biological Process	GO:0070574	cadmium ion transmembrane transport	SLC11A2	IDA		Human	PMID:12662899
Biological Process	GO:0070574	cadmium ion transmembrane transport	SLC11A2	IDA		Human	PMID:25326704
Biological Process	GO:0071456	cellular response to hypoxia	Slc11a2	IEP		Rat	PMID:21325818|RGD:5688411
Biological Process	GO:0071281	cellular response to iron ion	Slc11a2	IEP		Rat	PMID:17663481|RGD:5688717
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Slc11a2	IEP		Rat	PMID:16221503|RGD:5688725
Biological Process	GO:0006824	cobalt ion transport	Slc11a2	IDA		Mouse	PMID:12724326
Biological Process	GO:0098705	copper ion import across plasma membrane	Slc11a2	IMP		Rat	PMID:22442359|RGD:8554868
Biological Process	GO:0006825	copper ion transport	SLC11A2	IDA		Human	PMID:12734107
Biological Process	GO:0048813	dendrite morphogenesis	Slc11a2	IMP	MGI:MGI:2177768,MGI:MGI:3577916	Mouse	PMID:19211831
Biological Process	GO:0035162	embryonic hemopoiesis	slc11a2	IMP	ZFIN:ZDB-GENO-980202-517	Zfish	PMID:9007251
Biological Process	GO:0048821	erythrocyte development	Slc11a2	IMP	MGI:MGI:3577914	Mouse	PMID:15849611
Biological Process	GO:0051649	establishment of localization in cell	Slc11a2	IMP	MGI:MGI:1856400	Mouse	PMID:807277
Biological Process	GO:0006783	heme biosynthetic process	Slc11a2	IMP	MGI:MGI:1856400	Mouse	PMID:11739192
Biological Process	GO:0042541	hemoglobin biosynthetic process	slc11a2	IMP	ZFIN:ZDB-GENO-980202-517	Zfish	PMID:12393445
Biological Process	GO:0033212	iron import into cell	Slc11a2	IMP	MGI:MGI:1856400	Mouse	PMID:11739192
Biological Process	GO:0034755	iron ion transmembrane transport	SLC11A2	IDA		Human	PMID:17293870
Biological Process	GO:0006826	iron ion transport	SLC11A2	IDA		Human	PMID:12734107
Biological Process	GO:0006826	iron ion transport	SLC11A2	IDA		Human	PMID:17293870
Biological Process	GO:0006826	iron ion transport	Slc11a2	IMP	MGI:MGI:1856400	Mouse	PMID:15994289
Biological Process	GO:0006826	iron ion transport	Slc11a2	IMP	MGI:MGI:1856400	Mouse	PMID:807277
Biological Process	GO:0006826	iron ion transport	Slc11a2	IMP		Rat	PMID:16091957|RGD:1580427
Biological Process	GO:0015692	lead ion transport	SLC11A2	IDA		Human	PMID:12127992
Biological Process	GO:0007611	learning or memory	Slc11a2	IMP	MGI:MGI:2177768,MGI:MGI:3577916	Mouse	PMID:19211831
Biological Process	GO:0006828	manganese ion transport	SLC11A2	IDA		Human	PMID:17293870
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	SLC11A2	IMP		Human	PMID:15459009
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Slc11a2	IMP	MGI:MGI:1856400	Mouse	PMID:18076961
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Slc11a2	IMP	MGI:MGI:1856400	Mouse	PMID:5070129
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	Slc11a2	IMP	MGI:MGI:1856400	Mouse	PMID:658175
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	Slc11a2	IMP	MGI:MGI:1856400	Mouse	PMID:4404581
Biological Process	GO:0046686	response to cadmium ion	Slc11a2	IEP		Rat	PMID:19083094|RGD:2311406
Biological Process	GO:0046688	response to copper ion	slc11a2	IDA		Zfish	PMID:18987288
Biological Process	GO:0001666	response to hypoxia	Slc11a2	IEP		Rat	PMID:21325818|RGD:5688411
Biological Process	GO:0010039	response to iron ion	SLC11A2	IEP		Human	PMID:12734107
Biological Process	GO:0010039	response to iron ion	SLC11A2	IEP		Human	PMID:17109629
Biological Process	GO:0010039	response to iron ion	Slc11a2	IEP		Rat	PMID:12876064|RGD:1580429
Biological Process	GO:0010039	response to iron ion	slc11a2	IDA		Zfish	PMID:18987288
Biological Process	GO:0010288	response to lead ion	Slc11a2	IEP		Rat	PMID:19083094|RGD:2311406
Biological Process	GO:0010042	response to manganese ion	Slc11a2	IEP		Rat	PMID:17060373|RGD:2292035
Biological Process	GO:0010042	response to manganese ion	Slc11a2	IMP		Rat	PMID:18849539|RGD:2311407
Biological Process	GO:0010038	response to metal ion	slc11a2	IDA		Zfish	PMID:18987288
Biological Process	GO:0000041	transition metal ion transport	Slc11a2	IDA		Rat	PMID:9242408|RGD:729857

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern