Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Slc12a2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SLC12A2
- Mouse genes Slc12a2
- Rat genes Slc12a2
- Zfish genes slc12a2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc12a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008519	ammonium transmembrane transporter activity	SLC12A2	IDA		Human	PMID:12946942
Molecular Function	GO:0008519	ammonium transmembrane transporter activity	SLC12A2	IDA		Human	PMID:18032481
Molecular Function	GO:0015377	chloride:monoatomic cation symporter activity	SLC12A2	IDA		Human	PMID:7629105
Molecular Function	GO:0015377	chloride:monoatomic cation symporter activity	slc12a2	IDA		Zfish	PMID:31367042
Molecular Function	GO:0051879	Hsp90 protein binding	SLC12A2	IPI	UniProtKB:P07900	Human	PMID:15347682
Molecular Function	GO:0042802	identical protein binding	slc12a2	IPI	UniProtKB:A0A0G2KTI4	Zfish	PMID:31367042\|ZFIN:ZDB-PUB-190802-4
Molecular Function	GO:0046873	metal ion transmembrane transporter activity	SLC12A2	IDA		Human	PMID:15347682
Molecular Function	GO:0046873	metal ion transmembrane transporter activity	SLC12A2	IDA		Human	PMID:7629105
Molecular Function	GO:0015079	potassium ion transmembrane transporter activity	Slc12a2	IMP		Mouse	MGI:MGI:6392919\|PMID:11940530
Molecular Function	GO:0005515	protein binding	SLC12A2	IPI	UniProtKB:O95747	Human	PMID:17721439
Molecular Function	GO:0005515	protein binding	SLC12A2	IPI	UniProtKB:P15311	Human	PMID:22570591
Molecular Function	GO:0005515	protein binding	SLC12A2	IPI	UniProtKB:P15311	Human	PMID:24555568
Molecular Function	GO:0005515	protein binding	SLC12A2	IPI	UniProtKB:O95747	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Slc12a2	IPI	UniProtKB:P47811\|UniProtKB:Q9Z1W9	Mouse	MGI:MGI:3807765\|PMID:14563843
Molecular Function	GO:0005515	protein binding	Slc12a2	IPI	PR:Q6P9R2	Mouse	PMID:12386165
Molecular Function	GO:0019901	protein kinase binding	SLC12A2	IPI	UniProtKB:O88506	Human	PMID:12740379
Molecular Function	GO:0019901	protein kinase binding	SLC12A2	IPI	UniProtKB:O95747	Human	PMID:16669787
Molecular Function	GO:0019901	protein kinase binding	SLC12A2	IPI	UniProtKB:Q9UEW8	Human	PMID:16669787
Molecular Function	GO:0051087	protein-folding chaperone binding	SLC12A2	IPI	UniProtKB:P07900	Human	PMID:15347682
Molecular Function	GO:0008511	sodium:potassium:chloride symporter activity	Slc12a2	IMP		Rat	PMID:12556450\|RGD:1580435
Cellular Component	GO:0016324	apical plasma membrane	SLC12A2	IDA		Human	PMID:17478539
Cellular Component	GO:0016324	apical plasma membrane	Slc12a2	IDA		Mouse	PMID:12386165
Cellular Component	GO:0016324	apical plasma membrane	Slc12a2	IDA		Mouse	PMID:21705333
Cellular Component	GO:0009925	basal plasma membrane	SLC12A2	IDA		Human	PMID:17478539
Cellular Component	GO:0016323	basolateral plasma membrane	Slc12a2	IDA		Mouse	MGI:MGI:2446740\|PMID:12456807
Cellular Component	GO:0016323	basolateral plasma membrane	Slc12a2	IDA		Mouse	PMID:12040017
Cellular Component	GO:0016323	basolateral plasma membrane	slc12a2	IDA		Zfish	PMID:19633174
Cellular Component	GO:0044297	cell body	Slc12a2	IDA		Mouse	MGI:MGI:6392919\|PMID:11940530
Cellular Component	GO:0071944	cell periphery	SLC12A2	IDA		Human	PMID:16227993
Cellular Component	GO:0071944	cell periphery	Slc12a2	IDA		Mouse	MGI:MGI:5629870\|PMID:25716834
Cellular Component	GO:0042995	cell projection	Slc12a2	IDA		Mouse	MGI:MGI:6392919\|PMID:11940530
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	SLC12A2	IDA		Human	PMID:17478539
Cellular Component	GO:0005829	cytosol	Slc12a2	IDA		Rat	PMID:27798271\|RGD:14398833
Cellular Component	GO:0070062	extracellular exosome	SLC12A2	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	SLC12A2	HDA		Human	PMID:20458337
Cellular Component	GO:1903561	extracellular vesicle	SLC12A2	HDA		Human	PMID:24769233
Cellular Component	GO:0016328	lateral plasma membrane	SLC12A2	IDA		Human	PMID:17478539
Cellular Component	GO:0043005	neuron projection	SLC12A2	IDA		Human	PMID:16227993
Cellular Component	GO:0043025	neuronal cell body	SLC12A2	IDA		Human	PMID:16227993
Cellular Component	GO:0043025	neuronal cell body	Slc12a2	IDA		Mouse	MGI:MGI:5629870\|PMID:25716834
Cellular Component	GO:0005886	plasma membrane	SLC12A2	IDA		Human	PMID:7629105
Cellular Component	GO:0005886	plasma membrane	Slc12a2	IDA		Rat	PMID:12556450\|RGD:1580435
Biological Process	GO:0007568	aging	Slc12a2	IEP		Rat	PMID:21814290\|RGD:9587757
Biological Process	GO:0072488	ammonium transmembrane transport	SLC12A2	IDA		Human	PMID:12946942
Biological Process	GO:0072488	ammonium transmembrane transport	SLC12A2	IDA		Human	PMID:18032481
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	Slc12a2	IMP	MGI:MGI:1935144	Mouse	PMID:8864124
Biological Process	GO:0006884	cell volume homeostasis	Slc12a2	IMP		Mouse	MGI:MGI:6392919\|PMID:11940530
Biological Process	GO:1990869	cellular response to chemokine	SLC12A2	IMP		Human	PMID:27400149
Biological Process	GO:1990869	cellular response to chemokine	Slc12a2	IMP		Mouse	MGI:MGI:6141968\|PMID:27400149
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Slc12a2	IDA		Mouse	PMID:31786261
Biological Process	GO:0035865	cellular response to potassium ion	Slc12a2	IMP		Mouse	MGI:MGI:6392919\|PMID:11940530
Biological Process	GO:1902476	chloride transmembrane transport	Slc12a2	IMP		Mouse	MGI:MGI:6392919\|PMID:11940530
Biological Process	GO:0006821	chloride transport	Slc12a2	IMP		Rat	PMID:12556450\|RGD:1580435
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	Slc12a2	IMP	MGI:MGI:1935144	Mouse	PMID:16529873
Biological Process	GO:0043583	ear development	slc12a2	IMP	ZFIN:ZDB-GENO-980202-955	Zfish	PMID:9007244
Biological Process	GO:0043583	ear development	slc12a2	IMP	ZFIN:ZDB-GENO-980202-701	Zfish	PMID:9007244
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	Slc12a2	IMP		Rat	PMID:16227993\|RGD:1580584
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	Slc12a2	IEP		Rat	PMID:15090604\|RGD:1580436
Biological Process	GO:0006972	hyperosmotic response	Slc12a2	IMP		Rat	PMID:15284343\|RGD:1580437
Biological Process	GO:0042472	inner ear morphogenesis	slc12a2	IMP	ZFIN:ZDB-GENO-980202-955	Zfish	PMID:19633174
Biological Process	GO:0042472	inner ear morphogenesis	slc12a2	IMP	ZFIN:ZDB-GENO-980202-701,ZFIN:ZDB-MRPHLNO-090814-4	Zfish	PMID:19633174
Biological Process	GO:0042472	inner ear morphogenesis	slc12a2	IMP	ZFIN:ZDB-GENO-980202-701	Zfish	PMID:19633174
Biological Process	GO:0098658	inorganic anion import across plasma membrane	Slc12a2	IMP		Mouse	MGI:MGI:6392919\|PMID:11940530
Biological Process	GO:0098659	inorganic cation import across plasma membrane	SLC12A2	IDA		Human	PMID:15347682
Biological Process	GO:0098659	inorganic cation import across plasma membrane	SLC12A2	IDA		Human	PMID:7629105
Biological Process	GO:0030644	intracellular chloride ion homeostasis	Slc12a2	IMP		Mouse	MGI:MGI:6392919\|PMID:11940530
Biological Process	GO:0030007	intracellular potassium ion homeostasis	Slc12a2	IMP		Mouse	MGI:MGI:6392919\|PMID:11940530
Biological Process	GO:0006883	intracellular sodium ion homeostasis	Slc12a2	IMP		Mouse	MGI:MGI:6392919\|PMID:11940530
Biological Process	GO:0035633	maintenance of blood-brain barrier	Slc12a2	IMP		Mouse	MGI:MGI:6392927\|PMID:28577991
Biological Process	GO:0060763	mammary duct terminal end bud growth	Slc12a2	IMP	MGI:MGI:1935144	Mouse	PMID:12040017
Biological Process	GO:0035264	multicellular organism growth	Slc12a2	IMP	MGI:MGI:1935144	Mouse	PMID:12040017
Biological Process	GO:0061044	negative regulation of vascular wound healing	Slc12a2	IMP		Mouse	MGI:MGI:6392927\|PMID:28577991
Biological Process	GO:1904450	positive regulation of aspartate secretion	Slc12a2	IMP		Mouse	MGI:MGI:6392919\|PMID:11940530
Biological Process	GO:0045795	positive regulation of cell volume	Slc12a2	IMP		Rat	PMID:15284343\|RGD:1580437
Biological Process	GO:1990573	potassium ion import across plasma membrane	Slc12a2	IMP		Mouse	MGI:MGI:6392919\|PMID:11940530
Biological Process	GO:0006813	potassium ion transport	Slc12a2	IMP		Rat	PMID:12556450\|RGD:1580435
Biological Process	GO:1904464	regulation of matrix metallopeptidase secretion	Slc12a2	IMP		Mouse	MGI:MGI:6392927\|PMID:28577991
Biological Process	GO:0150003	regulation of spontaneous synaptic transmission	Slc12a2	IGI	UniProtKB:P09055	Mouse	MGI:MGI:5629870\|PMID:25716834
Biological Process	GO:0150003	regulation of spontaneous synaptic transmission	Slc12a2	IMP		Mouse	MGI:MGI:3608187\|PMID:16227993
Biological Process	GO:0150003	regulation of spontaneous synaptic transmission	Slc12a2	IMP		Rat	PMID:16227993\|RGD:1580584
Biological Process	GO:0098719	sodium ion import across plasma membrane	Slc12a2	IMP		Mouse	MGI:MGI:6392919\|PMID:11940530
Biological Process	GO:0006814	sodium ion transport	Slc12a2	IMP		Rat	PMID:12556450\|RGD:1580435
Biological Process	GO:0048798	swim bladder inflation	slc12a2	IMP	ZFIN:ZDB-GENO-980202-701	Zfish	PMID:19633174
Biological Process	GO:0048798	swim bladder inflation	slc12a2	IMP	ZFIN:ZDB-GENO-980202-955	Zfish	PMID:19633174
Biological Process	GO:0010818	T cell chemotaxis	SLC12A2	IMP		Human	PMID:27400149
Biological Process	GO:0010818	T cell chemotaxis	Slc12a2	IMP		Mouse	MGI:MGI:6141968\|PMID:27400149
Biological Process	GO:0070634	transepithelial ammonium transport	SLC12A2	IDA		Human	PMID:18032481
Biological Process	GO:0030321	transepithelial chloride transport	SLC12A2	IDA		Human	PMID:12946942

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.