Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC12A3
  • Mouse genes Slc12a3
  • Rat genes Slc12a3
  • Zfish genes slc12a3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc12a3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	Slc12a3	IPI	RGD:68430	Rat	PMID:11832422|RGD:632898
Molecular Function	GO:0005515	protein binding	SLC12A3	IPI	UniProtKB:Q9UH77	Human	PMID:22406640
Molecular Function	GO:0005515	protein binding	Slc12a3	IPI	UniProtKB:Q61098	Mouse	MGI:MGI:5689220|PMID:26099046
Molecular Function	GO:0015081	sodium ion transmembrane transporter activity	Slc12a3	IDA		Mouse	MGI:MGI:3843446|PMID:10516289
Molecular Function	GO:0015081	sodium ion transmembrane transporter activity	Slc12a3	IDA		Rat	PMID:16275913|RGD:8553410
Molecular Function	GO:0015378	sodium:chloride symporter activity	Slc12a3	IDA		Mouse	MGI:MGI:7388220|PMID:15068971
Molecular Function	GO:0015378	sodium:chloride symporter activity	Slc12a3	IDA		Rat	PMID:10894798|RGD:155663524
Molecular Function	GO:0015378	sodium:chloride symporter activity	Slc12a3	IDA		Rat	PMID:16624820|RGD:1624221
Molecular Function	GO:0015378	sodium:chloride symporter activity	Slc12a3	IMP		Rat	PMID:8021284|RGD:69999
Cellular Component	GO:0016324	apical plasma membrane	SLC12A3	IDA		Human	PMID:21397062
Cellular Component	GO:0016324	apical plasma membrane	Slc12a3	IDA		Mouse	MGI:MGI:3710722|PMID:12388412
Cellular Component	GO:0016324	apical plasma membrane	Slc12a3	IDA		Mouse	MGI:MGI:6381273|PMID:29993276
Cellular Component	GO:0016324	apical plasma membrane	Slc12a3	IDA		Mouse	PMID:11423561
Cellular Component	GO:0016324	apical plasma membrane	Slc12a3	IDA		Mouse	PMID:21397062
Cellular Component	GO:0016324	apical plasma membrane	Slc12a3	IDA		Rat	PMID:16554416|RGD:1624222
Cellular Component	GO:0005829	cytosol	Slc12a3	IDA		Mouse	MGI:MGI:3843446|PMID:10516289
Cellular Component	GO:0070062	extracellular exosome	SLC12A3	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	SLC12A3	IDA		Human	PMID:21082674
Cellular Component	GO:0070062	extracellular exosome	SLC12A3	HDA		Human	PMID:23533145
Cellular Component	GO:0005886	plasma membrane	Slc12a3	IDA		Mouse	MGI:MGI:3843446|PMID:10516289
Cellular Component	GO:0005886	plasma membrane	Slc12a3	IDA		Rat	PMID:16275913|RGD:8553410
Cellular Component	GO:0031982	vesicle	Slc12a3	IDA		Rat	PMID:16554416|RGD:1624222
Biological Process	GO:0071241	cellular response to inorganic substance	Slc12a3	IDA		Mouse	PMID:22846565
Biological Process	GO:0006821	chloride transport	Slc12a3	IMP		Rat	PMID:8021284|RGD:69999
Biological Process	GO:0035844	cloaca development	slc12a3	IMP	ZFIN:ZDB-MRPHLNO-150327-3	Zfish	PMID:25401745
Biological Process	GO:0039023	pronephric duct morphogenesis	slc12a3	IMP	ZFIN:ZDB-MRPHLNO-150327-3	Zfish	PMID:25401745
Biological Process	GO:0006468	protein phosphorylation	Slc12a3	IDA		Mouse	PMID:22846565
Biological Process	GO:1904044	response to aldosterone	Slc12a3	IDA		Mouse	PMID:19690383
Biological Process	GO:0002021	response to dietary excess	Slc12a3	IDA		Mouse	PMID:22846565
Biological Process	GO:0007165	signal transduction	Slc12a3	IMP		Mouse	PMID:22846565
Biological Process	GO:0035725	sodium ion transmembrane transport	Slc12a3	IDA		Mouse	PMID:24026181
Biological Process	GO:0035725	sodium ion transmembrane transport	Slc12a3	IDA		Rat	PMID:16275913|RGD:8553410
Biological Process	GO:0006814	sodium ion transport	Slc12a3	IMP		Mouse	MGI:MGI:3843446|PMID:10516289
Biological Process	GO:0006814	sodium ion transport	Slc12a3	IDA		Rat	PMID:16887815|RGD:1624220
Biological Process	GO:0006814	sodium ion transport	Slc12a3	IMP		Rat	PMID:8021284|RGD:69999

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern