Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC17A8
  • Mouse genes Slc17a8
  • Rat genes Slc17a8
  • Zfish genes slc17a8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc17a8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005254	chloride channel activity	Slc17a8	IDA		Rat	PMID:27133463|RGD:152025528
Molecular Function	GO:0140788	L-glutamate uniporter activity	SLC17A8	IDA		Human	PMID:12151341
Molecular Function	GO:0140788	L-glutamate uniporter activity	Slc17a8	IDA		Mouse	MGI:MGI:7260375|PMID:18080752
Molecular Function	GO:0140788	L-glutamate uniporter activity	Slc17a8	IDA		Mouse	PMID:12384506
Molecular Function	GO:0140788	L-glutamate uniporter activity	Slc17a8	IDA		Rat	PMID:12097496|RGD:628464
Molecular Function	GO:0140788	L-glutamate uniporter activity	Slc17a8	IDA		Rat	PMID:12388773|RGD:625707
Molecular Function	GO:0140788	L-glutamate uniporter activity	Slc17a8	IDA		Rat	PMID:27133463|RGD:152025528
Molecular Function	GO:0005436	sodium:phosphate symporter activity	SLC17A8	IDA		Human	PMID:33440152
Cellular Component	GO:0097440	apical dendrite	Slc17a8	IDA		Rat	PMID:15163690|RGD:9999165
Cellular Component	GO:0043679	axon terminus	Slc17a8	IDA		Rat	PMID:12388773|RGD:625707
Cellular Component	GO:0097441	basal dendrite	Slc17a8	IDA		Rat	PMID:15163690|RGD:9999165
Cellular Component	GO:0005737	cytoplasm	Slc17a8	IDA		Rat	PMID:24064385|RGD:9999152
Cellular Component	GO:0031410	cytoplasmic vesicle	Slc17a8	IDA		Rat	PMID:22573606|RGD:9999190
Cellular Component	GO:0030425	dendrite	Slc17a8	IDA		Rat	PMID:12388773|RGD:625707
Cellular Component	GO:0060076	excitatory synapse	Slc17a8	IDA		Rat	PMID:16519671|RGD:9999155
Cellular Component	GO:0097451	glial limiting end-foot	Slc17a8	IDA		Rat	PMID:12388773|RGD:625707
Cellular Component	GO:0005771	multivesicular body	Slc17a8	IDA		Rat	PMID:12388773|RGD:625707
Cellular Component	GO:0043025	neuronal cell body	Slc17a8	IDA		Rat	PMID:12388773|RGD:625707
Cellular Component	GO:1990030	pericellular basket	Slc17a8	IDA		Rat	PMID:18611437|RGD:9999159
Cellular Component	GO:0043204	perikaryon	Slc17a8	IDA		Rat	PMID:17435391|RGD:9999153
Cellular Component	GO:0045202	synapse	Slc17a8	IDA		Rat	PMID:12388773|RGD:625707
Cellular Component	GO:0008021	synaptic vesicle	Slc17a8	IDA		Mouse	PMID:27458190
Cellular Component	GO:0030672	synaptic vesicle membrane	Slc17a8	IDA		Mouse	PMID:12384506
Cellular Component	GO:0030672	synaptic vesicle membrane	Slc17a8	IMP		Mouse	PMID:23633129
Cellular Component	GO:0030672	synaptic vesicle membrane	Slc17a8	IEP		Mouse	PMID:23633129
Cellular Component	GO:0030672	synaptic vesicle membrane	Slc17a8	IDA		Mouse	PMID:23633129
Cellular Component	GO:0030672	synaptic vesicle membrane	Slc17a8	IDA		Rat	PMID:12388773|RGD:625707
Biological Process	GO:0007420	brain development	Slc17a8	IEP		Rat	PMID:15515175|RGD:9999149
Biological Process	GO:0090102	cochlea development	Slc17a8	IEP		Rat	PMID:24064385|RGD:9999152
Biological Process	GO:0050957	equilibrioception	slc17a8	IMP	ZFIN:ZDB-GENO-080630-2	Zfish	PMID:18305245
Biological Process	GO:0051938	L-glutamate import	Slc17a8	IMP		Rat	PMID:12097496|RGD:628464
Biological Process	GO:0051938	L-glutamate import	Slc17a8	IDA		Rat	PMID:12388773|RGD:625707
Biological Process	GO:0015813	L-glutamate transmembrane transport	SLC17A8	IDA		Human	PMID:12151341
Biological Process	GO:0015813	L-glutamate transmembrane transport	Slc17a8	IDA		Mouse	MGI:MGI:7260375|PMID:18080752
Biological Process	GO:0015813	L-glutamate transmembrane transport	Slc17a8	IDA		Mouse	PMID:12384506
Biological Process	GO:0015813	L-glutamate transmembrane transport	Slc17a8	IMP		Rat	PMID:12097496|RGD:628464
Biological Process	GO:0003407	neural retina development	Slc17a8	IEP		Rat	PMID:18482716|RGD:9999162
Biological Process	GO:0098700	neurotransmitter loading into synaptic vesicle	SLC17A8	IDA		Human	PMID:12097496
Biological Process	GO:0098700	neurotransmitter loading into synaptic vesicle	SLC17A8	IMP		Human	PMID:12097496
Biological Process	GO:0055062	phosphate ion homeostasis	SLC17A8	IDA		Human	PMID:33440152
Biological Process	GO:0051951	positive regulation of glutamate uptake involved in transmission of nerve impulse	Slc17a8	IMP		Mouse	MGI:MGI:3776705|PMID:18215623
Biological Process	GO:0051631	regulation of acetylcholine uptake	Slc17a8	IMP		Mouse	MGI:MGI:3794147|PMID:18278042
Biological Process	GO:0051631	regulation of acetylcholine uptake	Slc17a8	IDA		Rat	PMID:18278042|RGD:151665721
Biological Process	GO:0050803	regulation of synapse structure or activity	slc17a8	IMP	ZFIN:ZDB-GENO-080630-2	Zfish	PMID:18305245
Biological Process	GO:0060005	vestibular reflex	slc17a8	IMP	ZFIN:ZDB-GENO-080630-2	Zfish	PMID:18305245

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern