Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC18A3
  • Mouse genes Slc18a3
  • Rat genes Slc18a3
  • Zfish genes slc18a3a,slc18a3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc18a3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005277	acetylcholine transmembrane transporter activity	Slc18a3	IDA		Rat	PMID:8071310|RGD:61752
Molecular Function	GO:0005278	acetylcholine:proton antiporter activity	SLC18A3	IDA		Human	PMID:20225888
Molecular Function	GO:0005278	acetylcholine:proton antiporter activity	SLC18A3	IDA		Human	PMID:8910293
Molecular Function	GO:0005278	acetylcholine:proton antiporter activity	Slc18a3	IDA		Rat	PMID:8071310|RGD:61752
Molecular Function	GO:0015311	monoamine:proton antiporter activity	SLC18A3	IDA		Human	PMID:25355561
Molecular Function	GO:0005515	protein binding	SLC18A3	IPI	UniProtKB:I3L0A0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC18A3	IPI	UniProtKB:Q9GZY8-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC18A3	IPI	UniProtKB:Q9P0B6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Slc18a3	IPI	UniProtKB:Q92503	Mouse	MGI:MGI:5788393|PMID:17092608
Cellular Component	GO:0030121	AP-1 adaptor complex	Slc18a3	IDA		Rat	PMID:14724281|RGD:2317430
Cellular Component	GO:0030122	AP-2 adaptor complex	Slc18a3	IDA		Rat	PMID:14724281|RGD:2317430
Cellular Component	GO:0030424	axon	Slc18a3	IDA		Rat	PMID:19374941|RGD:2317425
Cellular Component	GO:0043679	axon terminus	Slc18a3	IDA		Rat	PMID:15306235|RGD:2317428
Cellular Component	GO:0098981	cholinergic synapse	Slc18a3	IDA		Mouse	PMID:4075114
Cellular Component	GO:0098981	cholinergic synapse	Slc18a3	EXP		Mouse	PMID:4075114
Cellular Component	GO:0098981	cholinergic synapse	Slc18a3	IDA		Rat	PMID:8601799|RGD:13702155
Cellular Component	GO:0098981	cholinergic synapse	Slc18a3	IDA		Rat	PMID:8622973|RGD:13702308
Cellular Component	GO:0005737	cytoplasm	Slc18a3	IDA		Mouse	PMID:21606356
Cellular Component	GO:0031410	cytoplasmic vesicle	Slc18a3	IDA		Rat	PMID:15924414|RGD:2317426
Cellular Component	GO:0031594	neuromuscular junction	Slc18a3	IDA		Rat	PMID:8622973|RGD:13702308
Cellular Component	GO:0031594	neuromuscular junction	Slc18a3	IDA		Rat	PMID:9182805|RGD:13702424
Cellular Component	GO:0031594	neuromuscular junction	Slc18a3	IMP		Rat	PMID:9182805|RGD:13702424
Cellular Component	GO:0043005	neuron projection	Slc18a3	IDA		Mouse	PMID:12074840
Cellular Component	GO:0008021	synaptic vesicle	Slc18a3	IDA		Rat	PMID:15306235|RGD:2317428
Cellular Component	GO:0030672	synaptic vesicle membrane	Slc18a3	IDA		Rat	PMID:8601799|RGD:13702155
Cellular Component	GO:0030672	synaptic vesicle membrane	Slc18a3	IDA		Rat	PMID:8622973|RGD:13702308
Cellular Component	GO:0030672	synaptic vesicle membrane	Slc18a3	IDA		Rat	PMID:9182805|RGD:13702424
Cellular Component	GO:0043195	terminal bouton	Slc18a3	IDA		Mouse	PMID:9853118
Biological Process	GO:0015870	acetylcholine transport	Slc18a3	IMP		Rat	PMID:15924414|RGD:2317426
Biological Process	GO:0051630	acetylcholine uptake	SLC18A3	IDA		Human	PMID:20225888
Biological Process	GO:0051630	acetylcholine uptake	SLC18A3	IDA		Human	PMID:25355561
Biological Process	GO:0051630	acetylcholine uptake	SLC18A3	IDA		Human	PMID:8910293
Biological Process	GO:0051630	acetylcholine uptake	Slc18a3	IDA		Rat	PMID:8071310|RGD:61752
Biological Process	GO:0098700	neurotransmitter loading into synaptic vesicle	Slc18a3	IDA		Mouse	PMID:4075114
Biological Process	GO:0098700	neurotransmitter loading into synaptic vesicle	Slc18a3	EXP		Mouse	PMID:4075114
Biological Process	GO:0098700	neurotransmitter loading into synaptic vesicle	Slc18a3	IDA		Rat	PMID:9182805|RGD:13702424
Biological Process	GO:0098700	neurotransmitter loading into synaptic vesicle	Slc18a3	IMP		Rat	PMID:9182805|RGD:13702424
Biological Process	GO:0014057	positive regulation of acetylcholine secretion, neurotransmission	Slc18a3	IMP		Mouse	MGI:MGI:4366600|PMID:19635813
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	Slc18a3	IMP		Mouse	MGI:MGI:5448761|PMID:23045697
Biological Process	GO:1904398	positive regulation of neuromuscular junction development	Slc18a3	IMP		Mouse	MGI:MGI:4366600|PMID:19635813
Biological Process	GO:0051610	serotonin uptake	SLC18A3	IDA		Human	PMID:25355561

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern