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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Slc22a1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc22a1
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:1901235(R)-carnitine transmembrane transporter activitySlc22a1IDAMouseMGI:MGI:6812762|PMID:34040533
Molecular FunctionGO:1901235(R)-carnitine transmembrane transporter activitySlc22a1IDAMouseMGI:MGI:6142338|PMID:28942964
Molecular FunctionGO:0005277acetylcholine transmembrane transporter activitySLC22A1IDAHumanPMID:15817714
Molecular FunctionGO:0005277acetylcholine transmembrane transporter activitySlc22a1IDARatPMID:15817714|RGD:2317432
Molecular FunctionGO:0005330dopamine:sodium symporter activitySlc22a1IDARatPMID:9776363|RGD:1643122
Molecular FunctionGO:0042802identical protein bindingSlc22a1IPIRGD:3224RatPMID:18361503|RGD:7243886
Molecular FunctionGO:0042802identical protein bindingSlc22a1IPIUniProtKB:Q63089RatPMID:21896487|RGD:8554312
Molecular FunctionGO:0008504monoamine transmembrane transporter activitySLC22A1IDAHumanPMID:12439218
Molecular FunctionGO:0008504monoamine transmembrane transporter activitySLC22A1IDAHumanPMID:24688079
Molecular FunctionGO:0008504monoamine transmembrane transporter activitySLC22A1IDAHumanPMID:24961373
Molecular FunctionGO:0008504monoamine transmembrane transporter activitySLC22A1IDAHumanPMID:35469921
Molecular FunctionGO:0008504monoamine transmembrane transporter activitySLC22A1IDAHumanPMID:9260930
Molecular FunctionGO:0008504monoamine transmembrane transporter activitySlc22a1IDAMouseMGI:MGI:7284498|PMID:35469921
Molecular FunctionGO:0008504monoamine transmembrane transporter activitySlc22a1IDAMouseMGI:MGI:5578250|PMID:24961373
Molecular FunctionGO:0008504monoamine transmembrane transporter activitySlc22a1IDARatPMID:10570053|RGD:155663521
Molecular FunctionGO:0008504monoamine transmembrane transporter activitySlc22a1IDARatPMID:11502595|RGD:155663523
Molecular FunctionGO:0008504monoamine transmembrane transporter activitySlc22a1IDARatPMID:15662044|RGD:155663532
Molecular FunctionGO:0008504monoamine transmembrane transporter activitySlc22a1IDARatPMID:16581093|RGD:155663558
Molecular FunctionGO:0008504monoamine transmembrane transporter activitySlc22a1IDARatPMID:8955087|RGD:155663519
Molecular FunctionGO:0008504monoamine transmembrane transporter activitySlc22a1IDARatPMID:9776363|RGD:1643122
Molecular FunctionGO:0005326neurotransmitter transmembrane transporter activitySLC22A1IDAHumanPMID:12439218
Molecular FunctionGO:0005326neurotransmitter transmembrane transporter activitySLC22A1IDAHumanPMID:24688079
Molecular FunctionGO:0005326neurotransmitter transmembrane transporter activitySLC22A1IDAHumanPMID:24961373
Molecular FunctionGO:0005326neurotransmitter transmembrane transporter activitySLC22A1IDAHumanPMID:35469921
Molecular FunctionGO:0005326neurotransmitter transmembrane transporter activitySlc22a1IDAMouseMGI:MGI:5578250|PMID:24961373
Molecular FunctionGO:0005326neurotransmitter transmembrane transporter activitySlc22a1IDAMouseMGI:MGI:7284498|PMID:35469921
Molecular FunctionGO:0005326neurotransmitter transmembrane transporter activitySlc22a1IDARatPMID:15662044|RGD:155663532
Molecular FunctionGO:0005326neurotransmitter transmembrane transporter activitySlc22a1IDARatPMID:16581093|RGD:155663558
Molecular FunctionGO:0005334norepinephrine:sodium symporter activitySlc22a1IDARatPMID:9776363|RGD:1643122
Molecular FunctionGO:0008514organic anion transmembrane transporter activitySLC22A1IDAHumanPMID:11907186
Molecular FunctionGO:0015101organic cation transmembrane transporter activitySLC22A1IDAHumanPMID:17460754
Molecular FunctionGO:0015101organic cation transmembrane transporter activitySLC22A1EXPHumanPMID:19141712
Molecular FunctionGO:0015101organic cation transmembrane transporter activitySLC22A1IDAHumanPMID:22806583
Molecular FunctionGO:0015101organic cation transmembrane transporter activitySLC22A1IDAHumanPMID:24291757
Molecular FunctionGO:0015101organic cation transmembrane transporter activitySLC22A1IDAHumanPMID:9260930
Molecular FunctionGO:0015101organic cation transmembrane transporter activitySlc22a1IDAMousePMID:12176030
Molecular FunctionGO:0015101organic cation transmembrane transporter activitySlc22a1IDARatPMID:10570053|RGD:155663521
Molecular FunctionGO:0015101organic cation transmembrane transporter activitySlc22a1IDARatPMID:11502595|RGD:155663523
Molecular FunctionGO:0015101organic cation transmembrane transporter activitySlc22a1IDARatPMID:18361503|RGD:7243886
Molecular FunctionGO:0015101organic cation transmembrane transporter activitySlc22a1IDARatPMID:7990927|RGD:634159
Molecular FunctionGO:0015101organic cation transmembrane transporter activitySlc22a1IDARatPMID:8955087|RGD:155663519
Molecular FunctionGO:0015132prostaglandin transmembrane transporter activitySLC22A1IDAHumanPMID:11907186
Molecular FunctionGO:0005515protein bindingSLC22A1IPIUniProtKB:Q96G23HumanPMID:11543633
Molecular FunctionGO:0005515protein bindingSLC22A1IPIUniProtKB:Q96G23HumanPMID:21988832
Molecular FunctionGO:0005515protein bindingSLC22A1IPIUniProtKB:Q9BZL3HumanPMID:32296183
Molecular FunctionGO:0015489putrescine transmembrane transporter activitySLC22A1IDAHumanPMID:21128598
Molecular FunctionGO:0015214pyrimidine nucleoside transmembrane transporter activitySLC22A1IMPHumanPMID:20477935
Molecular FunctionGO:0015214pyrimidine nucleoside transmembrane transporter activitySlc22a1IMPMouseMGI:MGI:6436440|PMID:20477935
Molecular FunctionGO:0015651quaternary ammonium group transmembrane transporter activitySLC22A1IDAHumanPMID:23567998
Molecular FunctionGO:0015651quaternary ammonium group transmembrane transporter activitySlc22a1IDAMouseMGI:MGI:7284498|PMID:35469921
Molecular FunctionGO:0015651quaternary ammonium group transmembrane transporter activitySlc22a1IDARatPMID:10570053|RGD:155663521
Molecular FunctionGO:0015651quaternary ammonium group transmembrane transporter activitySlc22a1IDARatPMID:11502595|RGD:155663523
Molecular FunctionGO:0015651quaternary ammonium group transmembrane transporter activitySlc22a1IDARatPMID:17567940|RGD:155663553
Molecular FunctionGO:0015651quaternary ammonium group transmembrane transporter activitySlc22a1IDARatPMID:17616214|RGD:1643126
Molecular FunctionGO:0015651quaternary ammonium group transmembrane transporter activitySlc22a1IDARatPMID:8955087|RGD:155663519
Molecular FunctionGO:0015651quaternary ammonium group transmembrane transporter activitySlc22a1IDARatPMID:9776363|RGD:1643122
Molecular FunctionGO:0015651quaternary ammonium group transmembrane transporter activitySlc22a1IDARatPMID:9808712|RGD:1643123
Molecular FunctionGO:0008513secondary active organic cation transmembrane transporter activitySlc22a1IDARatPMID:7990927|RGD:634159
Molecular FunctionGO:0015606spermidine transmembrane transporter activitySlc22a1IDAMouseMGI:MGI:7387165|PMID:23458604
Molecular FunctionGO:0015234thiamine transmembrane transporter activitySlc22a1IDAMouseMGI:MGI:5578250|PMID:24961373
Molecular FunctionGO:0015234thiamine transmembrane transporter activitySlc22a1IDAMouseMGI:MGI:7284498|PMID:35469921
Molecular FunctionGO:0019534toxin transmembrane transporter activitySLC22A1IMPHumanPMID:20477935
Molecular FunctionGO:0019534toxin transmembrane transporter activitySLC22A1IDAHumanPMID:22806583
Molecular FunctionGO:0019534toxin transmembrane transporter activitySLC22A1IDAHumanPMID:24291757
Molecular FunctionGO:0019534toxin transmembrane transporter activitySlc22a1IMPMouseMGI:MGI:6436440|PMID:20477935
Molecular FunctionGO:0019534toxin transmembrane transporter activitySlc22a1IMPRatPMID:20477935|RGD:30309941
Molecular FunctionGO:0022857transmembrane transporter activityslc22a2IDAZfishPMID:28363126
Molecular FunctionGO:0042910xenobiotic transmembrane transporter activitySLC22A1IDAHumanPMID:11408531
Molecular FunctionGO:0042910xenobiotic transmembrane transporter activitySLC22A1IDAHumanPMID:15389554
Molecular FunctionGO:0042910xenobiotic transmembrane transporter activitySLC22A1IMPHumanPMID:20477935
Molecular FunctionGO:0042910xenobiotic transmembrane transporter activitySLC22A1IMPHumanPMID:28362799
Molecular FunctionGO:0042910xenobiotic transmembrane transporter activitySLC22A1IDAHumanPMID:35469921
Molecular FunctionGO:0042910xenobiotic transmembrane transporter activitySLC22A1IDAHumanPMID:9260930
Molecular FunctionGO:0042910xenobiotic transmembrane transporter activitySlc22a1IDAMouseMGI:MGI:2137831|PMID:11463829
Molecular FunctionGO:0042910xenobiotic transmembrane transporter activitySlc22a1IMPMouseMGI:MGI:6436440|PMID:20477935
Molecular FunctionGO:0042910xenobiotic transmembrane transporter activitySlc22a1IDARatPMID:10864577|RGD:155663533
Molecular FunctionGO:0042910xenobiotic transmembrane transporter activitySlc22a1IDARatPMID:11408531|RGD:155663526
Molecular FunctionGO:0042910xenobiotic transmembrane transporter activitySlc22a1IDARatPMID:12395288|RGD:155663552
Molecular FunctionGO:0042910xenobiotic transmembrane transporter activitySlc22a1IMPRatPMID:20477935|RGD:30309941
Molecular FunctionGO:0042910xenobiotic transmembrane transporter activitySlc22a1IDARatPMID:8955087|RGD:155663519
Cellular ComponentGO:0016324apical plasma membraneSLC22A1IDAHumanPMID:15817714
Cellular ComponentGO:0016324apical plasma membraneSLC22A1IDAHumanPMID:19536068
Cellular ComponentGO:0016324apical plasma membraneSLC22A1IDAHumanPMID:23680637
Cellular ComponentGO:0016324apical plasma membraneSLC22A1IDAHumanPMID:20477935
Cellular ComponentGO:0016324apical plasma membraneSLC22A1IDAHumanPMID:28362799
Cellular ComponentGO:0016324apical plasma membraneSlc22a1IDAMouseMGI:MGI:7387166|PMID:23680637
Cellular ComponentGO:0016324apical plasma membraneSlc22a1IDAMouseMGI:MGI:6436440|PMID:20477935
Cellular ComponentGO:0016324apical plasma membraneSlc22a1IDARatPMID:15817714|RGD:2317432
Cellular ComponentGO:0016324apical plasma membraneSlc22a1IDARatPMID:20477935|RGD:30309941
Cellular ComponentGO:0009925basal plasma membraneSLC22A1IDAHumanPMID:35307651
Cellular ComponentGO:0016323basolateral plasma membraneSLC22A1IDAHumanPMID:12719534
Cellular ComponentGO:0016323basolateral plasma membraneSlc22a1IDAMouseMGI:MGI:6142338|PMID:28942964
Cellular ComponentGO:0016323basolateral plasma membraneSlc22a1IDARatPMID:10997918|RGD:1643124
Cellular ComponentGO:0016323basolateral plasma membraneSlc22a1IDARatPMID:11083459|RGD:155663544
Cellular ComponentGO:0016323basolateral plasma membraneSlc22a1IDARatPMID:7990927|RGD:634159
Cellular ComponentGO:0016323basolateral plasma membraneSlc22a1IDARatPMID:9703985|RGD:155663550
Cellular ComponentGO:0016323basolateral plasma membraneSlc22a1IDARatPMID:9808712|RGD:1643123
Cellular ComponentGO:0016328lateral plasma membraneSLC22A1IDAHumanPMID:16263091
Cellular ComponentGO:0005886plasma membraneSlc22a1IDARatPMID:12176030|RGD:8553962
Cellular ComponentGO:0005886plasma membraneslc22a2IDAZfishPMID:28363126
Biological ProcessGO:1902270(R)-carnitine transmembrane transportSlc22a1IDAMouseMGI:MGI:6142338|PMID:28942964
Biological ProcessGO:1902270(R)-carnitine transmembrane transportSlc22a1IDAMouseMGI:MGI:6812762|PMID:34040533
Biological ProcessGO:0015870acetylcholine transportSLC22A1IDAHumanPMID:15817714
Biological ProcessGO:0015870acetylcholine transportSlc22a1IDARatPMID:15817714|RGD:2317432
Biological ProcessGO:1902616acyl carnitine transmembrane transportSlc22a1IDAMouseMGI:MGI:6142338|PMID:28942964
Biological ProcessGO:1902616acyl carnitine transmembrane transportSlc22a1IDAMouseMGI:MGI:6812762|PMID:34040533
Biological ProcessGO:0061371determination of heart left/right asymmetryslc22a2IMPZFIN:ZDB-MRPHLNO-191114-5ZfishPMID:31075101
Biological ProcessGO:0015872dopamine transportSLC22A1IDAHumanPMID:35469921
Biological ProcessGO:0015872dopamine transportSlc22a1IDAMouseMGI:MGI:7284498|PMID:35469921
Biological ProcessGO:0015872dopamine transportSlc22a1IDARatPMID:16581093|RGD:155663558
Biological ProcessGO:0015872dopamine transportSlc22a1IDARatPMID:9776363|RGD:1643122
Biological ProcessGO:0090494dopamine uptakeSLC22A1IDAHumanPMID:24688079
Biological ProcessGO:0048241epinephrine transportSLC22A1IDAHumanPMID:35469921
Biological ProcessGO:0048241epinephrine transportSlc22a1IDAMouseMGI:MGI:7284498|PMID:35469921
Biological ProcessGO:0048241epinephrine transportSlc22a1IDARatPMID:16581093|RGD:155663558
Biological ProcessGO:0048241epinephrine transportSlc22a1IDARatPMID:9776363|RGD:1643122
Biological ProcessGO:0010248establishment or maintenance of transmembrane electrochemical gradientSlc22a1IDARatPMID:15817714|RGD:2317432
Biological ProcessGO:0072237metanephric proximal tubule developmentSlc22a1IEPRatPMID:30645697|RGD:155631307
Biological ProcessGO:0015844monoamine transportSLC22A1IDAHumanPMID:35469921
Biological ProcessGO:0015844monoamine transportSlc22a1IDAMouseMGI:MGI:7284498|PMID:35469921
Biological ProcessGO:0015844monoamine transportSlc22a1IDARatPMID:16581093|RGD:155663558
Biological ProcessGO:0015844monoamine transportSlc22a1IDARatPMID:9776363|RGD:1643122
Biological ProcessGO:0098655monoatomic cation transmembrane transportSlc22a1IDARatPMID:7990927|RGD:634159
Biological ProcessGO:0006812monoatomic cation transportSlc22a1IDAMousePMID:12176030
Biological ProcessGO:0006836neurotransmitter transportSLC22A1IDAHumanPMID:24688079
Biological ProcessGO:0015874norepinephrine transportSLC22A1IDAHumanPMID:24688079
Biological ProcessGO:0015874norepinephrine transportSlc22a1IDAMouseMGI:MGI:7284498|PMID:35469921
Biological ProcessGO:0015874norepinephrine transportSlc22a1IDARatPMID:16581093|RGD:155663558
Biological ProcessGO:0015874norepinephrine transportSlc22a1IDARatPMID:9776363|RGD:1643122
Biological ProcessGO:0015695organic cation transportSLC22A1IDAHumanPMID:22806583
Biological ProcessGO:0015695organic cation transportSLC22A1IDAHumanPMID:24291757
Biological ProcessGO:0015695organic cation transportSlc22a1IDAMouseMGI:MGI:2386434|PMID:12176030
Biological ProcessGO:0015695organic cation transportSlc22a1IDARatPMID:7990927|RGD:634159
Biological ProcessGO:0015732prostaglandin transportSLC22A1IDAHumanPMID:11907186
Biological ProcessGO:0015847putrescine transportSLC22A1IDAHumanPMID:21128598
Biological ProcessGO:0015697quaternary ammonium group transportSLC22A1IDAHumanPMID:23567998
Biological ProcessGO:0015697quaternary ammonium group transportSlc22a1IDARatPMID:17616214|RGD:1643126
Biological ProcessGO:0015697quaternary ammonium group transportSlc22a1IDARatPMID:9776363|RGD:1643122
Biological ProcessGO:0015697quaternary ammonium group transportSlc22a1IDARatPMID:9808712|RGD:1643123
Biological ProcessGO:0006837serotonin transportSLC22A1IDAHumanPMID:12439218
Biological ProcessGO:0006837serotonin transportSLC22A1IDAHumanPMID:24961373
Biological ProcessGO:0006837serotonin transportSLC22A1IDAHumanPMID:35469921
Biological ProcessGO:0006837serotonin transportSlc22a1IDAMouseMGI:MGI:5578250|PMID:24961373
Biological ProcessGO:0006837serotonin transportSlc22a1IDAMouseMGI:MGI:7284498|PMID:35469921
Biological ProcessGO:0006837serotonin transportSlc22a1IDARatPMID:15662044|RGD:155663532
Biological ProcessGO:0006837serotonin transportSlc22a1IDARatPMID:16581093|RGD:155663558
Biological ProcessGO:0051610serotonin uptakeSLC22A1IDAHumanPMID:24688079
Biological ProcessGO:0015848spermidine transportSlc22a1IDAMouseMGI:MGI:7387165|PMID:23458604
Biological ProcessGO:0071934thiamine transmembrane transportSLC22A1IDAHumanPMID:24961373
Biological ProcessGO:0071934thiamine transmembrane transportSLC22A1IDAHumanPMID:35469921
Biological ProcessGO:0071934thiamine transmembrane transportSlc22a1IDAMouseMGI:MGI:5578250|PMID:24961373
Biological ProcessGO:0071934thiamine transmembrane transportSlc22a1IDAMouseMGI:MGI:7284498|PMID:35469921
Biological ProcessGO:0015888thiamine transportSLC22A1IDAHumanPMID:24961373
Biological ProcessGO:0015888thiamine transportSLC22A1IDAHumanPMID:35469921
Biological ProcessGO:1901998toxin transportSLC22A1IMPHumanPMID:20477935
Biological ProcessGO:1901998toxin transportSLC22A1IDAHumanPMID:22806583
Biological ProcessGO:1901998toxin transportSLC22A1IDAHumanPMID:24291757
Biological ProcessGO:1901998toxin transportSlc22a1IMPMouseMGI:MGI:6436440|PMID:20477935
Biological ProcessGO:1901998toxin transportSlc22a1IMPRatPMID:20477935|RGD:30309941
Biological ProcessGO:0055085transmembrane transportSlc22a1IDAMouseMGI:MGI:2386434|PMID:12176030
Biological ProcessGO:0042908xenobiotic transportSLC22A1IDAHumanPMID:11408531
Biological ProcessGO:0042908xenobiotic transportSLC22A1IDAHumanPMID:15389554
Biological ProcessGO:0042908xenobiotic transportSLC22A1IMPHumanPMID:20477935
Biological ProcessGO:0042908xenobiotic transportSLC22A1IDAHumanPMID:22806583
Biological ProcessGO:0042908xenobiotic transportSLC22A1IDAHumanPMID:24291757
Biological ProcessGO:0042908xenobiotic transportSLC22A1IMPHumanPMID:28362799
Biological ProcessGO:0042908xenobiotic transportSLC22A1IDAHumanPMID:35469921
Biological ProcessGO:0042908xenobiotic transportSLC22A1IDAHumanPMID:9260930
Biological ProcessGO:0042908xenobiotic transportSlc22a1IDAMouseMGI:MGI:2137831|PMID:11463829
Biological ProcessGO:0042908xenobiotic transportSlc22a1IMPMouseMGI:MGI:6436440|PMID:20477935
Biological ProcessGO:0042908xenobiotic transportSlc22a1IDARatPMID:10864577|RGD:155663533
Biological ProcessGO:0042908xenobiotic transportSlc22a1IDARatPMID:11408531|RGD:155663526
Biological ProcessGO:0042908xenobiotic transportSlc22a1IDARatPMID:12395288|RGD:155663552
Biological ProcessGO:0042908xenobiotic transportSlc22a1IMPRatPMID:20477935|RGD:30309941
Biological ProcessGO:0042908xenobiotic transportSlc22a1IDARatPMID:8955087|RGD:155663519

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory