Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Slc22a21

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SLC22A5
- Mouse genes Slc22a21
- Rat genes Slc22a5
- Zfish genes slc22a21
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc22a21

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1901235	(R)-carnitine transmembrane transporter activity	SLC22A5	IDA		Human	PMID:17509700
Molecular Function	GO:1901235	(R)-carnitine transmembrane transporter activity	SLC22A5	IDA		Human	PMID:20722056
Molecular Function	GO:1901235	(R)-carnitine transmembrane transporter activity	SLC22A5	IMP		Human	PMID:23877104
Molecular Function	GO:1901235	(R)-carnitine transmembrane transporter activity	SLC22A5	IDA		Human	PMID:33334877
Molecular Function	GO:1901235	(R)-carnitine transmembrane transporter activity	Slc22a5	IMP		Rat	PMID:28257821\|RGD:30309931
Molecular Function	GO:0015199	amino-acid betaine transmembrane transporter activity	slc22a21	IDA		Zfish	PMID:25746775
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	SLC22A5	IDA		Human	PMID:10454528
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	SLC22A5	IDA		Human	PMID:10966938
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	SLC22A5	IDA		Human	PMID:17855766
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	SLC22A5	EXP		Human	PMID:9685390
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	SLC22A5	IDA		Human	PMID:9685390
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	SLC22A5	IMP		Human	PMID:9916797
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	Slc22a21	IDA		Mouse	PMID:12535646
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	Slc22a21	IDA		Mouse	PMID:11010964
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	Slc22a5	IDA		Rat	PMID:10454528\|RGD:70011
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	Slc22a5	IDA		Rat	PMID:10525100\|RGD:155230696
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	Slc22a5	IDA		Rat	PMID:10636865\|RGD:1643135
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	Slc22a5	IDA		Rat	PMID:12644265\|RGD:1643141
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	Slc22a5	IDA		Rat	PMID:15923388\|RGD:1643142
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	Slc22a5	IMP		Rat	PMID:16322553\|RGD:1643150
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	Slc22a5	IDA		Rat	PMID:9792817\|RGD:730132
Molecular Function	GO:0030165	PDZ domain binding	SLC22A5	IPI	UniProtKB:Q5T2W1	Human	PMID:15523054
Molecular Function	GO:0005515	protein binding	SLC22A5	IPI	UniProtKB:Q15599	Human	PMID:15523054
Molecular Function	GO:0005515	protein binding	SLC22A5	IPI	UniProtKB:Q86UT5	Human	PMID:15523054
Molecular Function	GO:0005515	protein binding	SLC22A5	IPI	UniProtKB:O76011	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC22A5	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC22A5	IPI	UniProtKB:Q5JR59-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC22A5	IPI	UniProtKB:Q7Z3Y8	Human	PMID:32296183
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	SLC22A5	IMP		Human	PMID:10454528
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	SLC22A5	IMP		Human	PMID:10966938
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	SLC22A5	IDA		Human	PMID:23567998
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	SLC22A5	IDA		Human	PMID:9618255
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	Slc22a5	IMP		Rat	PMID:10454528\|RGD:70011
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	Slc22a5	IDA		Rat	PMID:10636865\|RGD:1643135
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	Slc22a5	IDA		Rat	PMID:12644265\|RGD:1643141
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	Slc22a5	IDA		Rat	PMID:17616214\|RGD:1643126
Cellular Component	GO:0016324	apical plasma membrane	SLC22A5	IDA		Human	PMID:17274673
Cellular Component	GO:0016324	apical plasma membrane	SLC22A5	IDA		Human	PMID:18641280
Cellular Component	GO:0016324	apical plasma membrane	SLC22A5	IDA		Human	PMID:20722056
Cellular Component	GO:0009925	basal plasma membrane	SLC22A5	IDA		Human	PMID:35307651
Cellular Component	GO:0016323	basolateral plasma membrane	Slc22a5	IDA		Rat	PMID:12080034\|RGD:1643143
Cellular Component	GO:0031526	brush border membrane	SLC22A5	IDA		Human	PMID:15238359
Cellular Component	GO:0005737	cytoplasm	Slc22a5	IDA		Rat	PMID:28257821\|RGD:30309931
Cellular Component	GO:0005829	cytosol	Slc22a5	IDA		Rat	PMID:17995936\|RGD:30309932
Cellular Component	GO:0070062	extracellular exosome	SLC22A5	HDA		Human	PMID:19056867
Cellular Component	GO:0005778	peroxisomal membrane	Slc22a21	IDA		Mouse	MGI:MGI:3611015\|PMID:16288981
Cellular Component	GO:0005777	peroxisome	Slc22a21	IDA		Mouse	PMID:12535646
Cellular Component	GO:0005886	plasma membrane	SLC22A5	IDA		Human	PMID:17509700
Cellular Component	GO:0005886	plasma membrane	Slc22a5	IDA		Rat	PMID:17995936\|RGD:30309932
Cellular Component	GO:0005886	plasma membrane	Slc22a5	IDA		Rat	PMID:28257821\|RGD:30309931
Biological Process	GO:1902270	(R)-carnitine transmembrane transport	SLC22A5	IDA		Human	PMID:10454528
Biological Process	GO:1902270	(R)-carnitine transmembrane transport	SLC22A5	IDA		Human	PMID:10966938
Biological Process	GO:1902270	(R)-carnitine transmembrane transport	SLC22A5	IDA		Human	PMID:17855766
Biological Process	GO:1902270	(R)-carnitine transmembrane transport	SLC22A5	IMP		Human	PMID:23877104
Biological Process	GO:1902270	(R)-carnitine transmembrane transport	Slc22a5	IDA		Rat	PMID:10454528\|RGD:70011
Biological Process	GO:1902270	(R)-carnitine transmembrane transport	Slc22a5	IDA		Rat	PMID:10525100\|RGD:155230696
Biological Process	GO:1902270	(R)-carnitine transmembrane transport	Slc22a5	IMP		Rat	PMID:28257821\|RGD:30309931
Biological Process	GO:1900749	(R)-carnitine transport	SLC22A5	IDA		Human	PMID:17509700
Biological Process	GO:1900749	(R)-carnitine transport	SLC22A5	IDA		Human	PMID:20722056
Biological Process	GO:1900749	(R)-carnitine transport	SLC22A5	IDA		Human	PMID:33334877
Biological Process	GO:0015838	amino-acid betaine transport	slc22a21	IDA		Zfish	PMID:25746775\|ZFIN:ZDB-PUB-150311-19
Biological Process	GO:0015838	amino-acid betaine transport	slc22a21	IDA		Zfish	PMID:25746775
Biological Process	GO:1902603	carnitine transmembrane transport	Slc22a21	IDA		Mouse	MGI:MGI:2450198\|PMID:12535646
Biological Process	GO:0015879	carnitine transport	SLC22A5	IDA		Human	PMID:9685390
Biological Process	GO:0015879	carnitine transport	SLC22A5	IMP		Human	PMID:9916797
Biological Process	GO:0015879	carnitine transport	Slc22a21	IDA		Mouse	PMID:12535646
Biological Process	GO:0015879	carnitine transport	Slc22a21	IDA		Mouse	PMID:11010964
Biological Process	GO:0015879	carnitine transport	Slc22a5	IDA		Rat	PMID:10636865\|RGD:1643135
Biological Process	GO:0015879	carnitine transport	Slc22a5	IDA		Rat	PMID:12644265\|RGD:1643141
Biological Process	GO:0015879	carnitine transport	Slc22a5	IDA		Rat	PMID:15923388\|RGD:1643142
Biological Process	GO:0015879	carnitine transport	Slc22a5	IMP		Rat	PMID:16322553\|RGD:1643150
Biological Process	GO:0015879	carnitine transport	Slc22a5	IDA		Rat	PMID:9792817\|RGD:730132
Biological Process	GO:0015695	organic cation transport	slc22a21	IDA		Zfish	PMID:25746775\|ZFIN:ZDB-PUB-150311-19
Biological Process	GO:0060731	positive regulation of intestinal epithelial structure maintenance	SLC22A5	IMP		Human	PMID:18005709
Biological Process	GO:0015697	quaternary ammonium group transport	SLC22A5	IMP		Human	PMID:10454528
Biological Process	GO:0015697	quaternary ammonium group transport	SLC22A5	IMP		Human	PMID:10966938
Biological Process	GO:0015697	quaternary ammonium group transport	SLC22A5	IDA		Human	PMID:23567998
Biological Process	GO:0015697	quaternary ammonium group transport	SLC22A5	IDA		Human	PMID:9618255
Biological Process	GO:0015697	quaternary ammonium group transport	Slc22a5	IMP		Rat	PMID:10454528\|RGD:70011
Biological Process	GO:0015697	quaternary ammonium group transport	Slc22a5	IDA		Rat	PMID:10636865\|RGD:1643135
Biological Process	GO:0015697	quaternary ammonium group transport	Slc22a5	IDA		Rat	PMID:12644265\|RGD:1643141
Biological Process	GO:0015697	quaternary ammonium group transport	Slc22a5	IDA		Rat	PMID:17616214\|RGD:1643126
Biological Process	GO:0009609	response to symbiotic bacterium	SLC22A5	IMP		Human	PMID:18005709
Biological Process	GO:0034612	response to tumor necrosis factor	SLC22A5	IDA		Human	PMID:20722056
Biological Process	GO:0034341	response to type II interferon	SLC22A5	IDA		Human	PMID:20722056
Biological Process	GO:0070715	sodium-dependent organic cation transport	SLC22A5	IDA		Human	PMID:15238359
Biological Process	GO:0070715	sodium-dependent organic cation transport	SLC22A5	IDA		Human	PMID:9685390
Biological Process	GO:0055085	transmembrane transport	slc22a21	IDA		Zfish	PMID:25746775\|ZFIN:ZDB-PUB-150311-19

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.