Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC22A4
  • Mouse genes Slc22a4
  • Rat genes Slc22a4
  • Zfish genes slc22a21,slc22a4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc22a4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015171	amino acid transmembrane transporter activity	SLC22A4	IDA		Human	PMID:23567998
Molecular Function	GO:0015199	amino-acid betaine transmembrane transporter activity	slc22a21	IDA		Zfish	PMID:25746775
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	SLC22A4	IDA		Human	PMID:16729965
Molecular Function	GO:0015226	carnitine transmembrane transporter activity	Slc22a4	IDA		Mouse	PMID:11010964
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	Slc22a4	IDA		Rat	PMID:10825452|RGD:633351
Molecular Function	GO:0030165	PDZ domain binding	SLC22A4	IPI	UniProtKB:Q5T2W1	Human	PMID:15523054
Molecular Function	GO:0005515	protein binding	SLC22A4	IPI	UniProtKB:O14745	Human	PMID:15523054
Molecular Function	GO:0005515	protein binding	SLC22A4	IPI	UniProtKB:Q15599	Human	PMID:15523054
Molecular Function	GO:0005515	protein binding	SLC22A4	IPI	UniProtKB:Q86UT5	Human	PMID:15523054
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	SLC22A4	IDA		Human	PMID:23567998
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	SLC22A4	IDA		Human	PMID:9426230
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	Slc22a4	IMP		Rat	PMID:10825452|RGD:633351
Molecular Function	GO:0015651	quaternary ammonium group transmembrane transporter activity	Slc22a4	IDA		Rat	PMID:17616214|RGD:1643126
Cellular Component	GO:0016324	apical plasma membrane	SLC22A4	IDA		Human	PMID:18641280
Cellular Component	GO:0009925	basal plasma membrane	SLC22A4	IDA		Human	PMID:35307651
Cellular Component	GO:0005739	mitochondrion	SLC22A4	IDA		Human	PMID:16729965
Cellular Component	GO:0005739	mitochondrion	Slc22a4	IDA		Mouse	PMID:16729965
Cellular Component	GO:0005739	mitochondrion	Slc22a4	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Slc22a4	HDA		Mouse	PMID:14651853
Biological Process	GO:0089718	amino acid import across plasma membrane	SLC22A4	IDA		Human	PMID:23567998
Biological Process	GO:0015838	amino-acid betaine transport	slc22a21	IDA		Zfish	PMID:25746775|ZFIN:ZDB-PUB-150311-19
Biological Process	GO:0015838	amino-acid betaine transport	slc22a21	IDA		Zfish	PMID:25746775
Biological Process	GO:0009437	carnitine metabolic process	Slc22a4	IGI	UniProtKB:Q9H015	Mouse	PMID:10655497
Biological Process	GO:0015879	carnitine transport	SLC22A4	IDA		Human	PMID:16729965
Biological Process	GO:0015879	carnitine transport	Slc22a4	IDA		Mouse	PMID:11010964
Biological Process	GO:0050787	detoxification of mercury ion	slc22a4	IDA		Zfish	PMID:23709046
Biological Process	GO:0015698	inorganic anion transport	slc22a4	IMP	ZFIN:ZDB-MRPHLNO-131003-6	Zfish	PMID:23709046
Biological Process	GO:0015695	organic cation transport	slc22a21	IDA		Zfish	PMID:25746775|ZFIN:ZDB-PUB-150311-19
Biological Process	GO:0015697	quaternary ammonium group transport	SLC22A4	IDA		Human	PMID:23567998
Biological Process	GO:0015697	quaternary ammonium group transport	SLC22A4	IDA		Human	PMID:9426230
Biological Process	GO:0015697	quaternary ammonium group transport	Slc22a4	IDA		Mouse	PMID:11010964
Biological Process	GO:0015697	quaternary ammonium group transport	Slc22a4	IMP		Rat	PMID:10825452|RGD:633351
Biological Process	GO:0015697	quaternary ammonium group transport	Slc22a4	IDA		Rat	PMID:17616214|RGD:1643126
Biological Process	GO:0051597	response to methylmercury	slc22a4	IMP	ZFIN:ZDB-MRPHLNO-131003-6	Zfish	PMID:23709046
Biological Process	GO:0051597	response to methylmercury	slc22a4	IMP	ZFIN:ZDB-MRPHLNO-131003-8	Zfish	PMID:23709046
Biological Process	GO:0001887	selenium compound metabolic process	slc22a4	IDA		Zfish	PMID:23709046
Biological Process	GO:0055085	transmembrane transport	slc22a21	IDA		Zfish	PMID:25746775|ZFIN:ZDB-PUB-150311-19
Biological Process	GO:0006641	triglyceride metabolic process	Slc22a4	IGI	UniProtKB:Q9H015	Mouse	PMID:10655497
Biological Process	GO:0042908	xenobiotic transport	SLC22A4	IDA		Human	PMID:23567998

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern