Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC26A4
  • Mouse genes Slc26a4
  • Rat genes Slc26a4
  • Zfish genes slc26a4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc26a4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015108	chloride transmembrane transporter activity	SLC26A4	IDA		Human	PMID:12107249
Molecular Function	GO:0015108	chloride transmembrane transporter activity	SLC26A4	IMP		Human	PMID:24051746
Molecular Function	GO:0015108	chloride transmembrane transporter activity	Slc26a4	IDA		Rat	PMID:12107249|RGD:1599218
Molecular Function	GO:0140900	chloride:bicarbonate antiporter activity	SLC26A4	IMP		Human	PMID:24051746
Molecular Function	GO:0140900	chloride:bicarbonate antiporter activity	SLC26A4	IDA		Human	PMID:35601831
Molecular Function	GO:0140900	chloride:bicarbonate antiporter activity	Slc26a4	IMP		Mouse	MGI:MGI:6834617|PMID:11274445
Molecular Function	GO:0140900	chloride:bicarbonate antiporter activity	Slc26a4	IDA		Mouse	MGI:MGI:5291569|PMID:18565999
Molecular Function	GO:0140900	chloride:bicarbonate antiporter activity	Slc26a4	IDA		Rat	PMID:11208611|RGD:155663516
Molecular Function	GO:0015111	iodide transmembrane transporter activity	SLC26A4	IMP		Human	PMID:11932316
Molecular Function	GO:0015111	iodide transmembrane transporter activity	SLC26A4	IDA		Human	PMID:12107249
Molecular Function	GO:0015111	iodide transmembrane transporter activity	Slc26a4	IDA		Rat	PMID:12107249|RGD:1599218
Molecular Function	GO:0015111	iodide transmembrane transporter activity	Slc26a4	IDA		Rat	PMID:26791486|RGD:11531946
Molecular Function	GO:0005515	protein binding	SLC26A4	IPI	UniProtKB:P46940	Human	PMID:35601831
Molecular Function	GO:0005515	protein binding	Slc26a4	IPI	UniProtKB:Q9JKF1	Mouse	MGI:MGI:7388224|PMID:35601831
Cellular Component	GO:0016324	apical plasma membrane	SLC26A4	IDA		Human	PMID:11274445
Cellular Component	GO:0016324	apical plasma membrane	SLC26A4	IDA		Human	PMID:16928804
Cellular Component	GO:0016324	apical plasma membrane	SLC26A4	IDA		Human	PMID:35601831
Cellular Component	GO:0016324	apical plasma membrane	Slc26a4	IDA		Mouse	MGI:MGI:2159729|PMID:11459928
Cellular Component	GO:0016324	apical plasma membrane	Slc26a4	IDA		Mouse	MGI:MGI:5291569|PMID:18565999
Cellular Component	GO:0016324	apical plasma membrane	Slc26a4	IDA		Mouse	MGI:MGI:3607624|PMID:16144965
Cellular Component	GO:0016324	apical plasma membrane	Slc26a4	IDA		Mouse	MGI:MGI:3850621|PMID:15385584
Cellular Component	GO:0016324	apical plasma membrane	Slc26a4	IDA		Mouse	MGI:MGI:7388224|PMID:35601831
Cellular Component	GO:0016324	apical plasma membrane	Slc26a4	IDA		Mouse	MGI:MGI:6834617|PMID:11274445
Cellular Component	GO:0016324	apical plasma membrane	Slc26a4	IDA		Mouse	MGI:MGI:3710722|PMID:12388412
Cellular Component	GO:0016324	apical plasma membrane	Slc26a4	IDA		Rat	PMID:11208611|RGD:155663516
Cellular Component	GO:0016324	apical plasma membrane	Slc26a4	IDA		Rat	PMID:11274445|RGD:155663555
Cellular Component	GO:0016324	apical plasma membrane	Slc26a4	IDA		Rat	PMID:12388388|RGD:634144
Cellular Component	GO:0031526	brush border membrane	Slc26a4	IDA		Mouse	MGI:MGI:2159729|PMID:11459928
Cellular Component	GO:0070062	extracellular exosome	SLC26A4	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	SLC26A4	IDA		Human	PMID:21082674
Cellular Component	GO:0016020	membrane	Slc26a4	IDA		Mouse	PMID:17409310
Cellular Component	GO:0005886	plasma membrane	SLC26A4	IMP		Human	PMID:11932316
Cellular Component	GO:0005886	plasma membrane	SLC26A4	IMP		Human	PMID:24051746
Cellular Component	GO:0005886	plasma membrane	Slc26a4	IDA		Rat	PMID:26791486|RGD:11531946
Biological Process	GO:0006821	chloride transport	slc26a4	IMP	ZFIN:ZDB-MRPHLNO-091216-2	Zfish	PMID:19801433
Biological Process	GO:0015698	inorganic anion transport	Slc26a4	IDA		Rat	PMID:12107249|RGD:1599218
Biological Process	GO:0015705	iodide transport	SLC26A4	IMP		Human	PMID:16684826
Biological Process	GO:0055081	monoatomic anion homeostasis	slc26a4	IDA		Zfish	PMID:19641131
Biological Process	GO:0006885	regulation of pH	Slc26a4	IMP		Mouse	MGI:MGI:3607624|PMID:16144965
Biological Process	GO:0032880	regulation of protein localization	Slc26a4	IMP		Mouse	MGI:MGI:3607624|PMID:16144965
Biological Process	GO:0009651	response to salt stress	slc26a4	IDA		Zfish	PMID:19641131

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern