Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Slc39a8

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SLC39A8
- Mouse genes Slc39a8
- Rat genes Slc39a8
- Zfish genes slc39a8
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc39a8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140410	monoatomic cation:bicarbonate symporter activity	SLC39A8	IDA		Human	PMID:22898811
Molecular Function	GO:0140410	monoatomic cation:bicarbonate symporter activity	SLC39A8	IDA		Human	PMID:27166256
Molecular Function	GO:0140410	monoatomic cation:bicarbonate symporter activity	SLC39A8	IDA		Human	PMID:27466201
Molecular Function	GO:0140410	monoatomic cation:bicarbonate symporter activity	SLC39A8	IDA		Human	PMID:28481222
Molecular Function	GO:0140410	monoatomic cation:bicarbonate symporter activity	SLC39A8	IDA		Human	PMID:29453449
Molecular Function	GO:0140410	monoatomic cation:bicarbonate symporter activity	SLC39A8	IDA		Human	PMID:31699897
Molecular Function	GO:0140410	monoatomic cation:bicarbonate symporter activity	Slc39a8	IDA		Mouse	MGI:MGI:6384424\|PMID:27166256
Molecular Function	GO:0140410	monoatomic cation:bicarbonate symporter activity	Slc39a8	IDA		Mouse	MGI:MGI:6383564\|PMID:16638970
Molecular Function	GO:0140410	monoatomic cation:bicarbonate symporter activity	Slc39a8	IDA		Mouse	MGI:MGI:6383250\|PMID:18037372
Molecular Function	GO:0140410	monoatomic cation:bicarbonate symporter activity	Slc39a8	IDA		Mouse	MGI:MGI:5912781\|PMID:28481222
Molecular Function	GO:0140410	monoatomic cation:bicarbonate symporter activity	Slc39a8	IDA		Rat	PMID:22898811\|RGD:15090842
Molecular Function	GO:0140412	zinc:bicarbonate symporter activity	Slc39a8	IDA		Mouse	MGI:MGI:6383250\|PMID:18037372
Molecular Function	GO:0140412	zinc:bicarbonate symporter activity	Slc39a8	IDA		Mouse	MGI:MGI:6117959\|PMID:29337306
Molecular Function	GO:0140412	zinc:bicarbonate symporter activity	Slc39a8	IDA		Rat	PMID:22898811\|RGD:15090842
Cellular Component	GO:0016324	apical plasma membrane	SLC39A8	IDA		Human	PMID:31699897
Cellular Component	GO:0016324	apical plasma membrane	Slc39a8	IDA		Mouse	MGI:MGI:5912781\|PMID:28481222
Cellular Component	GO:0016324	apical plasma membrane	Slc39a8	IDA		Mouse	MGI:MGI:3760074\|PMID:17108009
Cellular Component	GO:0016324	apical plasma membrane	Slc39a8	IDA		Mouse	MGI:MGI:6383564\|PMID:16638970
Cellular Component	GO:0016323	basolateral plasma membrane	SLC39A8	IDA		Human	PMID:31699897
Cellular Component	GO:0005765	lysosomal membrane	SLC39A8	IDA		Human	PMID:18390834
Cellular Component	GO:0005765	lysosomal membrane	SLC39A8	IDA		Human	PMID:19401385
Cellular Component	GO:0031090	organelle membrane	SLC39A8	IDA		Human	PMID:12504855
Cellular Component	GO:0005886	plasma membrane	SLC39A8	IDA		Human	PMID:18390834
Cellular Component	GO:0005886	plasma membrane	Slc39a8	IDA		Mouse	MGI:MGI:6383250\|PMID:18037372
Cellular Component	GO:0005886	plasma membrane	Slc39a8	IDA		Mouse	MGI:MGI:6384424\|PMID:27166256
Cellular Component	GO:0005886	plasma membrane	Slc39a8	IDA		Mouse	PMID:15722412
Cellular Component	GO:0005886	plasma membrane	Slc39a8	IDA		Rat	PMID:22898811\|RGD:15090842
Biological Process	GO:0006525	arginine metabolic process	Slc39a8	IMP		Mouse	MGI:MGI:5912781\|PMID:28481222
Biological Process	GO:0015701	bicarbonate transport	Slc39a8	IDA		Mouse	MGI:MGI:6383564\|PMID:16638970
Biological Process	GO:0015701	bicarbonate transport	Slc39a8	IDA		Mouse	MGI:MGI:6383250\|PMID:18037372
Biological Process	GO:0070574	cadmium ion transmembrane transport	SLC39A8	IDA		Human	PMID:27466201
Biological Process	GO:0070574	cadmium ion transmembrane transport	Slc39a8	IDA		Mouse	MGI:MGI:6383250\|PMID:18037372
Biological Process	GO:0070574	cadmium ion transmembrane transport	Slc39a8	IMP		Mouse	MGI:MGI:6383325\|PMID:30015240
Biological Process	GO:0070574	cadmium ion transmembrane transport	Slc39a8	IDA		Mouse	MGI:MGI:6383564\|PMID:16638970
Biological Process	GO:0070574	cadmium ion transmembrane transport	Slc39a8	IDA		Mouse	PMID:15722412
Biological Process	GO:0070574	cadmium ion transmembrane transport	Slc39a8	IDA		Rat	PMID:22898811\|RGD:15090842
Biological Process	GO:1990079	cartilage homeostasis	Slc39a8	IMP		Mouse	MGI:MGI:5577232\|PMID:24529376
Biological Process	GO:0098849	cellular detoxification of cadmium ion	SLC39A8	IMP		Human	PMID:27466201
Biological Process	GO:0006824	cobalt ion transport	Slc39a8	IDA		Rat	PMID:22898811\|RGD:15090842
Biological Process	GO:0006351	DNA-templated transcription	Slc39a8	IMP		Mouse	MGI:MGI:5577232\|PMID:24529376
Biological Process	GO:0030198	extracellular matrix organization	SLC39A8	IMP		Human	PMID:29337306
Biological Process	GO:0030198	extracellular matrix organization	Slc39a8	IMP		Mouse	MGI:MGI:6117959\|PMID:29337306
Biological Process	GO:0030026	intracellular manganese ion homeostasis	Slc39a8	IMP		Mouse	MGI:MGI:5912781\|PMID:28481222
Biological Process	GO:0006882	intracellular zinc ion homeostasis	SLC39A8	IDA		Human	PMID:19401385
Biological Process	GO:0006882	intracellular zinc ion homeostasis	Slc39a8	IDA		Mouse	MGI:MGI:5577232\|PMID:24529376
Biological Process	GO:0098711	iron ion import across plasma membrane	SLC39A8	IDA		Human	PMID:22898811
Biological Process	GO:0098711	iron ion import across plasma membrane	Slc39a8	IDA		Mouse	MGI:MGI:7339319\|PMID:22898811
Biological Process	GO:0098711	iron ion import across plasma membrane	Slc39a8	IMP		Mouse	MGI:MGI:6383325\|PMID:30015240
Biological Process	GO:0098711	iron ion import across plasma membrane	Slc39a8	IDA		Rat	PMID:22898811\|RGD:15090842
Biological Process	GO:0061757	leukocyte adhesion to arterial endothelial cell	Slc39a8	IMP		Mouse	MGI:MGI:6383325\|PMID:30015240
Biological Process	GO:0071421	manganese ion transmembrane transport	SLC39A8	IMP		Human	PMID:28481222
Biological Process	GO:0071421	manganese ion transmembrane transport	SLC39A8	IMP		Human	PMID:29453449
Biological Process	GO:0071421	manganese ion transmembrane transport	SLC39A8	IMP		Human	PMID:31699897
Biological Process	GO:0071421	manganese ion transmembrane transport	Slc39a8	IMP		Mouse	MGI:MGI:5912781\|PMID:28481222
Biological Process	GO:0071421	manganese ion transmembrane transport	Slc39a8	IDA		Mouse	MGI:MGI:6383564\|PMID:16638970
Biological Process	GO:0071421	manganese ion transmembrane transport	Slc39a8	IDA		Rat	PMID:22898811\|RGD:15090842
Biological Process	GO:0071421	manganese ion transmembrane transport	slc39a8	IMP	ZFIN:ZDB-GENO-191114-5	Zfish	PMID:30301978
Biological Process	GO:0015694	mercury ion transport	Slc39a8	IDA		Mouse	MGI:MGI:6383564\|PMID:16638970
Biological Process	GO:1990540	mitochondrial manganese ion transmembrane transport	SLC39A8	IMP		Human	PMID:29453449
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	SLC39A8	IMP		Human	PMID:23403290
Biological Process	GO:0050728	negative regulation of inflammatory response	SLC39A8	IMP		Human	PMID:23403290
Biological Process	GO:0097080	plasma membrane selenite transport	SLC39A8	IDA		Human	PMID:27166256
Biological Process	GO:0097080	plasma membrane selenite transport	Slc39a8	IDA		Mouse	MGI:MGI:6384424\|PMID:27166256
Biological Process	GO:0006487	protein N-linked glycosylation	Slc39a8	IMP		Mouse	MGI:MGI:5912781\|PMID:28481222
Biological Process	GO:0006355	regulation of DNA-templated transcription	SLC39A8	IMP		Human	PMID:29337306
Biological Process	GO:0006355	regulation of DNA-templated transcription	Slc39a8	IMP		Mouse	MGI:MGI:6117959\|PMID:29337306
Biological Process	GO:0042391	regulation of membrane potential	SLC39A8	IMP		Human	PMID:18390834
Biological Process	GO:0071578	zinc ion import across plasma membrane	SLC39A8	IMP		Human	PMID:23403290
Biological Process	GO:0071578	zinc ion import across plasma membrane	SLC39A8	IMP		Human	PMID:29337306
Biological Process	GO:0071578	zinc ion import across plasma membrane	Slc39a8	IMP		Mouse	MGI:MGI:6383325\|PMID:30015240
Biological Process	GO:0071578	zinc ion import across plasma membrane	Slc39a8	IDA		Mouse	MGI:MGI:6383250\|PMID:18037372
Biological Process	GO:0071578	zinc ion import across plasma membrane	Slc39a8	IMP		Mouse	MGI:MGI:6117959\|PMID:29337306
Biological Process	GO:0071578	zinc ion import across plasma membrane	Slc39a8	IDA		Rat	PMID:22898811\|RGD:15090842
Biological Process	GO:0071577	zinc ion transmembrane transport	SLC39A8	IMP		Human	PMID:18390834
Biological Process	GO:0071577	zinc ion transmembrane transport	SLC39A8	IDA		Human	PMID:19401385
Biological Process	GO:0071577	zinc ion transmembrane transport	Slc39a8	IMP		Mouse	MGI:MGI:5577232\|PMID:24529376
Biological Process	GO:0006829	zinc ion transport	SLC39A8	IMP		Human	PMID:12504855

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.