Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC40A1
  • Mouse genes Slc40a1
  • Rat genes Slc40a1
  • Zfish genes slc40a1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc40a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015093	ferrous iron transmembrane transporter activity	Slc40a1	IDA		Mouse	MGI:MGI:3521561|PMID:15514116
Molecular Function	GO:0042802	identical protein binding	Slc40a1	IPI	UniProtKB:Q9JHI9	Mouse	MGI:MGI:5913977|PMID:19234114
Molecular Function	GO:0005381	iron ion transmembrane transporter activity	SLC40A1	IMP		Human	PMID:12091367
Molecular Function	GO:0005381	iron ion transmembrane transporter activity	Slc40a1	IDA		Mouse	MGI:MGI:3521561|PMID:15514116
Molecular Function	GO:0005381	iron ion transmembrane transporter activity	Slc40a1	IDA		Mouse	PMID:10828623
Molecular Function	GO:0005381	iron ion transmembrane transporter activity	slc40a1	IDA		Zfish	PMID:10693807
Molecular Function	GO:0005381	iron ion transmembrane transporter activity	slc40a1	IMP	ZFIN:ZDB-GENO-980202-94	Zfish	PMID:15902304
Molecular Function	GO:0017046	peptide hormone binding	SLC40A1	IPI	UniProtKB:P81172:PRO_0000013379	Human	PMID:22682227
Molecular Function	GO:0017046	peptide hormone binding	Slc40a1	IPI	UniProtKB:P81172:PRO_0000013379	Mouse	MGI:MGI:3521561|PMID:15514116
Molecular Function	GO:0005515	protein binding	SLC40A1	IPI	UniProtKB:P05067	Human	PMID:20817278
Molecular Function	GO:0005515	protein binding	SLC40A1	IPI	UniProtKB:P05067	Human	PMID:24867889
Molecular Function	GO:0005515	protein binding	Slc40a1	IPI	UniProtKB:O60674	Mouse	MGI:MGI:5913977|PMID:19234114
Molecular Function	GO:0005515	protein binding	Slc40a1	IPI	UniProtKB:P12023	Mouse	MGI:MGI:4881369|PMID:20817278
Molecular Function	GO:0005515	protein binding	Slc40a1	IPI	PR:P42227	Mouse	PMID:20530874
Cellular Component	GO:0016323	basolateral plasma membrane	SLC40A1	IDA		Human	PMID:20019163
Cellular Component	GO:0016323	basolateral plasma membrane	Slc40a1	IGI	UniProtKB:P20722	Mouse	MGI:MGI:4352622|PMID:19252488
Cellular Component	GO:0005829	cytosol	SLC40A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SLC40A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SLC40A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SLC40A1	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005886	plasma membrane	SLC40A1	IDA		Human	PMID:20019163
Cellular Component	GO:0005886	plasma membrane	SLC40A1	IDA		Human	PMID:30247984
Cellular Component	GO:0005886	plasma membrane	Slc40a1	IDA		Mouse	PMID:16081696
Cellular Component	GO:0005886	plasma membrane	Slc40a1	IDA		Mouse	PMID:21700773
Cellular Component	GO:0008021	synaptic vesicle	Slc40a1	IDA		Mouse	PMID:14972659
Biological Process	GO:0006915	apoptotic process	Slc40a1	IMP	MGI:MGI:1889622	Mouse	PMID:15342464
Biological Process	GO:0030282	bone mineralization	slc40a1	IMP	ZFIN:ZDB-GENO-101220-8	Zfish	PMID:27184405
Biological Process	GO:0035162	embryonic hemopoiesis	slc40a1	IMP	ZFIN:ZDB-MRPHLNO-060601-4	Zfish	PMID:16089502
Biological Process	GO:0035162	embryonic hemopoiesis	slc40a1	IMP	ZFIN:ZDB-GENO-980202-94	Zfish	PMID:9007251
Biological Process	GO:0035162	embryonic hemopoiesis	slc40a1	IMP	ZFIN:ZDB-GENO-980202-802	Zfish	PMID:9007251
Biological Process	GO:0003158	endothelium development	Slc40a1	IMP	MGI:MGI:1889622	Mouse	PMID:15342464
Biological Process	GO:0051649	establishment of localization in cell	Slc40a1	IGI	MGI:MGI:1933533	Mouse	PMID:21700773
Biological Process	GO:0042541	hemoglobin biosynthetic process	slc40a1	IMP	ZFIN:ZDB-GENO-980202-94	Zfish	PMID:15902304
Biological Process	GO:0006879	intracellular iron ion homeostasis	SLC40A1	IMP		Human	PMID:12091367
Biological Process	GO:0006879	intracellular iron ion homeostasis	slc40a1	IMP	ZFIN:ZDB-GENO-101220-8	Zfish	PMID:27184405
Biological Process	GO:1903988	iron ion export across plasma membrane	Slc40a1	IDA		Mouse	MGI:MGI:3521561|PMID:15514116
Biological Process	GO:0034755	iron ion transmembrane transport	SLC40A1	IMP		Human	PMID:12091367
Biological Process	GO:0034755	iron ion transmembrane transport	Slc40a1	IGI	MGI:MGI:1933533	Mouse	PMID:21700773
Biological Process	GO:0006826	iron ion transport	Slc40a1	IDA		Mouse	PMID:10828623
Biological Process	GO:0006826	iron ion transport	slc40a1	IMP	ZFIN:ZDB-GENO-980202-94	Zfish	PMID:15902304
Biological Process	GO:0006826	iron ion transport	slc40a1	IMP	ZFIN:ZDB-GENO-060825-5	Zfish	PMID:10693807
Biological Process	GO:0002260	lymphocyte homeostasis	Slc40a1	IMP	MGI:MGI:1889622	Mouse	PMID:15888661
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Slc40a1	IMP		Mouse	MGI:MGI:3039043|PMID:15084469
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Slc40a1	IMP	MGI:MGI:1889622	Mouse	PMID:15342464
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Slc40a1	IMP	MGI:MGI:1889622	Mouse	PMID:19596281
Biological Process	GO:0043066	negative regulation of apoptotic process	Slc40a1	IMP	MGI:MGI:1889622	Mouse	PMID:15342464
Biological Process	GO:0043362	nucleate erythrocyte maturation	slc40a1	IMP	ZFIN:ZDB-GENO-980202-94	Zfish	PMID:15902304
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Slc40a1	IGI	MGI:MGI:1933533	Mouse	PMID:20530874
Biological Process	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron	Slc40a1	IDA		Mouse	PMID:23395172
Biological Process	GO:0046688	response to copper ion	slc40a1	IDA		Zfish	PMID:18987288
Biological Process	GO:0010039	response to iron ion	slc40a1	IDA		Zfish	PMID:18987288
Biological Process	GO:0048536	spleen development	Slc40a1	IMP	MGI:MGI:1889622	Mouse	PMID:15342464
Biological Process	GO:0060345	spleen trabecula formation	Slc40a1	IMP	MGI:MGI:1889622	Mouse	PMID:15342464
Biological Process	GO:0006366	transcription by RNA polymerase II	Slc40a1	IGI	MGI:MGI:1933533	Mouse	PMID:20530874

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern