Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC46A1
  • Mouse genes Slc46a1
  • Rat genes Slc46a1
  • Zfish genes slc46a1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc46a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008517	folic acid transmembrane transporter activity	SLC46A1	IDA		Human	PMID:17129779
Molecular Function	GO:0008517	folic acid transmembrane transporter activity	SLC46A1	IDA		Human	PMID:17475902
Molecular Function	GO:0008517	folic acid transmembrane transporter activity	SLC46A1	IMP		Human	PMID:19762432
Molecular Function	GO:0008517	folic acid transmembrane transporter activity	SLC46A1	IDA		Human	PMID:29344585
Molecular Function	GO:0008517	folic acid transmembrane transporter activity	SLC46A1	IDA		Human	PMID:32893190
Molecular Function	GO:0008517	folic acid transmembrane transporter activity	SLC46A1	IDA		Human	PMID:34619546
Molecular Function	GO:0008517	folic acid transmembrane transporter activity	Slc46a1	IDA		Rat	PMID:18174275|RGD:7244263
Molecular Function	GO:0008517	folic acid transmembrane transporter activity	Slc46a1	IDA		Rat	PMID:23287122|RGD:7244264
Molecular Function	GO:0140211	folic acid:proton symporter activity	SLC46A1	IDA		Human	PMID:19389703
Molecular Function	GO:0140211	folic acid:proton symporter activity	SLC46A1	IDA		Human	PMID:34040256
Molecular Function	GO:0140211	folic acid:proton symporter activity	Slc46a1	IDA		Mouse	MGI:MGI:3762977|PMID:17962486
Molecular Function	GO:0015232	heme transmembrane transporter activity	Slc46a1	IDA		Mouse	MGI:MGI:3715073|PMID:16143108
Molecular Function	GO:0015350	methotrexate transmembrane transporter activity	Slc46a1	IDA		Mouse	MGI:MGI:3762977|PMID:17962486
Molecular Function	GO:0015078	proton transmembrane transporter activity	SLC46A1	IDA		Human	PMID:17129779
Molecular Function	GO:0015293	symporter activity	SLC46A1	IDA		Human	PMID:17475902
Cellular Component	GO:0016324	apical plasma membrane	SLC46A1	IDA		Human	PMID:17475902
Cellular Component	GO:0016324	apical plasma membrane	SLC46A1	IDA		Human	PMID:19762432
Cellular Component	GO:0016324	apical plasma membrane	SLC46A1	IDA		Human	PMID:31791063
Cellular Component	GO:0016324	apical plasma membrane	Slc46a1	IDA		Mouse	MGI:MGI:3715073|PMID:16143108
Cellular Component	GO:0016323	basolateral plasma membrane	SLC46A1	IDA		Human	PMID:19074442
Cellular Component	GO:0016323	basolateral plasma membrane	SLC46A1	IDA		Human	PMID:31791063
Cellular Component	GO:0016323	basolateral plasma membrane	Slc46a1	IDA		Mouse	MGI:MGI:6867141|PMID:19074442
Cellular Component	GO:0031526	brush border membrane	Slc46a1	IDA		Rat	PMID:23287122|RGD:7244264
Cellular Component	GO:0009986	cell surface	SLC46A1	HDA		Human	PMID:19581412
Cellular Component	GO:0005737	cytoplasm	Slc46a1	IDA		Mouse	MGI:MGI:3715073|PMID:16143108
Cellular Component	GO:0005768	endosome	SLC46A1	IDA		Human	PMID:19074442
Cellular Component	GO:0005886	plasma membrane	SLC46A1	IDA		Human	PMID:29344585
Cellular Component	GO:0005886	plasma membrane	SLC46A1	IDA		Human	PMID:32893190
Cellular Component	GO:0005886	plasma membrane	SLC46A1	IDA		Human	PMID:34619546
Cellular Component	GO:0005886	plasma membrane	SLC46A1	IDA		Human	PMID:17129779
Cellular Component	GO:0005886	plasma membrane	SLC46A1	IDA		Human	PMID:28112518
Biological Process	GO:1904447	folate import across plasma membrane	SLC46A1	IDA		Human	PMID:19389703
Biological Process	GO:1904447	folate import across plasma membrane	SLC46A1	IDA		Human	PMID:19762432
Biological Process	GO:1904447	folate import across plasma membrane	SLC46A1	IDA		Human	PMID:34040256
Biological Process	GO:1904447	folate import across plasma membrane	Slc46a1	IDA		Mouse	MGI:MGI:3762977|PMID:17962486
Biological Process	GO:0098838	folate transmembrane transport	SLC46A1	IMP		Human	PMID:17129779
Biological Process	GO:0098838	folate transmembrane transport	SLC46A1	IMP		Human	PMID:19074442
Biological Process	GO:0015884	folic acid transport	SLC46A1	IDA		Human	PMID:17129779
Biological Process	GO:0015884	folic acid transport	SLC46A1	IDA		Human	PMID:17475902
Biological Process	GO:0015884	folic acid transport	SLC46A1	IDA		Human	PMID:19762432
Biological Process	GO:0015884	folic acid transport	SLC46A1	IMP		Human	PMID:31494288
Biological Process	GO:0015884	folic acid transport	Slc46a1	IDA		Rat	PMID:18174275|RGD:7244263
Biological Process	GO:0015884	folic acid transport	Slc46a1	IDA		Rat	PMID:23287122|RGD:7244264
Biological Process	GO:0015886	heme transport	Slc46a1	IDA		Mouse	MGI:MGI:3715073|PMID:16143108
Biological Process	GO:1902600	proton transmembrane transport	SLC46A1	IDA		Human	PMID:17129779

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern