Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC4A4
  • Mouse genes Slc4a4
  • Rat genes Slc4a4
  • Zfish genes slc4a4a,slc4a4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc4a4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	SLC4A4	IPI	UniProtKB:Q9Y6R1	Human	PMID:29500354
Molecular Function	GO:0005515	protein binding	SLC4A4	IPI	UniProtKB:P00918	Human	PMID:15218065
Molecular Function	GO:0005515	protein binding	SLC4A4	IPI	UniProtKB:P22748	Human	PMID:15563508
Molecular Function	GO:0005515	protein binding	SLC4A4	IPI	UniProtKB:O43865	Human	PMID:16769890
Molecular Function	GO:0005515	protein binding	Slc4a4	IPI	UniProtKB:Q80SW1	Mouse	MGI:MGI:3831619|PMID:19033647
Molecular Function	GO:0005515	protein binding	Slc4a4	IPI	UniProtKB:P00920	Mouse	MGI:MGI:7310187|PMID:15218065
Molecular Function	GO:0005515	protein binding	Slc4a4	IPI	UniProtKB:Q64444	Mouse	MGI:MGI:5499727|PMID:14567693
Molecular Function	GO:0005515	protein binding	Slc4a4	IPI	PR:Q80SW1	Mouse	PMID:16769890
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IDA		Human	PMID:10069984
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IDA		Human	PMID:11744745
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IDA		Human	PMID:12411514
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IDA		Human	PMID:12730338
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IDA		Human	PMID:12907161
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IMP		Human	PMID:15218065
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IMP		Human	PMID:15713912
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IMP		Human	PMID:15817634
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IMP		Human	PMID:15930088
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IMP		Human	PMID:16636648
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IMP		Human	PMID:17661077
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IDA		Human	PMID:23324180
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IMP		Human	PMID:23636456
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IMP		Human	PMID:29500354
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IDA		Human	PMID:9235899
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A4	IDA		Human	PMID:9651366
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	Slc4a4	IDA		Mouse	MGI:MGI:7310008|PMID:11171615
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	Slc4a4	IDA		Mouse	MGI:MGI:3831619|PMID:19033647
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	Slc4a4	IDA		Mouse	MGI:MGI:7310009|PMID:12388213
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	Slc4a4	IDA		Rat	PMID:10648705|RGD:1299161
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	Slc4a4	IDA		Rat	PMID:10837348|RGD:152995545
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	Slc4a4	IMP		Rat	PMID:12604466|RGD:152995563
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	Slc4a4	IDA		Rat	PMID:9486238|RGD:1299162
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	slc4a4a	IDA		Zfish	PMID:19625604
Molecular Function	GO:0015293	symporter activity	SLC4A4	IMP		Human	PMID:29500354
Cellular Component	GO:0016323	basolateral plasma membrane	SLC4A4	IMP		Human	PMID:15713912
Cellular Component	GO:0016323	basolateral plasma membrane	SLC4A4	IDA		Human	PMID:17182531
Cellular Component	GO:0016323	basolateral plasma membrane	SLC4A4	IDA		Human	PMID:17661077
Cellular Component	GO:0016323	basolateral plasma membrane	SLC4A4	IDA		Human	PMID:12907161
Cellular Component	GO:0016323	basolateral plasma membrane	SLC4A4	IDA		Human	PMID:15273250
Cellular Component	GO:0016323	basolateral plasma membrane	Slc4a4	IDA		Mouse	MGI:MGI:7310008|PMID:11171615
Cellular Component	GO:0009986	cell surface	SLC4A4	IDA		Human	PMID:29500354
Cellular Component	GO:0070062	extracellular exosome	SLC4A4	HDA		Human	PMID:19056867
Cellular Component	GO:0016020	membrane	SLC4A4	IDA		Human	PMID:10069984
Cellular Component	GO:0016020	membrane	SLC4A4	IDA		Human	PMID:27717805
Cellular Component	GO:0016020	membrane	Slc4a4	IDA		Rat	PMID:10069984|RGD:15090856
Cellular Component	GO:0005886	plasma membrane	SLC4A4	IDA		Human	PMID:16636648
Cellular Component	GO:0005886	plasma membrane	SLC4A4	IMP		Human	PMID:15817634
Cellular Component	GO:0005886	plasma membrane	SLC4A4	IMP		Human	PMID:15930088
Cellular Component	GO:0005886	plasma membrane	SLC4A4	IDA		Human	PMID:23324180
Cellular Component	GO:0005886	plasma membrane	SLC4A4	IMP		Human	PMID:23636456
Cellular Component	GO:0005886	plasma membrane	SLC4A4	IDA		Human	PMID:29500354
Cellular Component	GO:0005886	plasma membrane	SLC4A4	IDA		Human	PMID:10069984
Biological Process	GO:0015701	bicarbonate transport	SLC4A4	IDA		Human	PMID:10069984
Biological Process	GO:0015701	bicarbonate transport	SLC4A4	IMP		Human	PMID:16636648
Biological Process	GO:0015701	bicarbonate transport	Slc4a4	IGI	MGI:MGI:2385184	Mouse	PMID:19033647
Biological Process	GO:0015701	bicarbonate transport	slc4a4a	IDA		Zfish	PMID:19625604|ZFIN:ZDB-PUB-090727-12
Biological Process	GO:0051649	establishment of localization in cell	Slc4a4	IGI	MGI:MGI:2385184	Mouse	PMID:19033647
Biological Process	GO:0072237	metanephric proximal tubule development	Slc4a4	IEP		Rat	PMID:30645697|RGD:155631307
Biological Process	GO:0045821	positive regulation of glycolytic process	SLC4A4	IGI	UniProtKB:Q9JK62	Human	PMID:21976511
Biological Process	GO:0045821	positive regulation of glycolytic process	Slc4a4	IMP		Mouse	MGI:MGI:5295108|PMID:21976511
Biological Process	GO:0051453	regulation of intracellular pH	SLC4A4	IDA		Human	PMID:10069984
Biological Process	GO:0051453	regulation of intracellular pH	SLC4A4	IGI	UniProtKB:Q9JK62	Human	PMID:21976511
Biological Process	GO:0051453	regulation of intracellular pH	SLC4A4	IMP		Human	PMID:24453308
Biological Process	GO:0051453	regulation of intracellular pH	Slc4a4	IMP		Mouse	MGI:MGI:5295108|PMID:21976511
Biological Process	GO:0051453	regulation of intracellular pH	Slc4a4	IMP		Mouse	MGI:MGI:5553185|PMID:24453308
Biological Process	GO:0042391	regulation of membrane potential	SLC4A4	IDA		Human	PMID:10069984
Biological Process	GO:0042391	regulation of membrane potential	SLC4A4	IDA		Human	PMID:15273250
Biological Process	GO:0042391	regulation of membrane potential	Slc4a4	IMP		Mouse	MGI:MGI:5295108|PMID:21976511
Biological Process	GO:0036376	sodium ion export across plasma membrane	SLC4A4	IMP		Human	PMID:16636648
Biological Process	GO:0035725	sodium ion transmembrane transport	SLC4A4	IDA		Human	PMID:10069984
Biological Process	GO:0035725	sodium ion transmembrane transport	slc4a4a	IDA		Zfish	PMID:19625604|ZFIN:ZDB-PUB-090727-12
Biological Process	GO:0006814	sodium ion transport	SLC4A4	IDA		Human	PMID:16769890
Biological Process	GO:0006814	sodium ion transport	Slc4a4	IDA		Mouse	PMID:9651366
Biological Process	GO:0055085	transmembrane transport	SLC4A4	IMP		Human	PMID:29500354

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern