Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC4A8
  • Mouse genes Slc4a8
  • Rat genes Slc4a8
  • Zfish genes slc4a8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc4a8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015106	bicarbonate transmembrane transporter activity	SLC4A8	IDA		Human	PMID:11133997
Molecular Function	GO:0015108	chloride transmembrane transporter activity	SLC4A8	IDA		Human	PMID:11133997
Molecular Function	GO:0042802	identical protein binding	Slc4a8	IDA		Rat	PMID:34584093|RGD:155230735
Molecular Function	GO:0015081	sodium ion transmembrane transporter activity	SLC4A8	IDA		Human	PMID:11133997
Molecular Function	GO:0140892	sodium,bicarbonate:chloride antiporter activity	Slc4a8	IDA		Mouse	MGI:MGI:4459366|PMID:20389022
Molecular Function	GO:0140892	sodium,bicarbonate:chloride antiporter activity	Slc4a8	IMP		Rat	PMID:34584093|RGD:155230735
Molecular Function	GO:0140892	sodium,bicarbonate:chloride antiporter activity	Slc4a8	IDA		Rat	PMID:8189393|RGD:155230769
Molecular Function	GO:0008510	sodium:bicarbonate symporter activity	SLC4A8	IDA		Human	PMID:11133997
Cellular Component	GO:0032279	asymmetric synapse	Slc4a8	IDA		Rat	PMID:22102085|RGD:15090838
Cellular Component	GO:0043679	axon terminus	Slc4a8	IDA		Rat	PMID:22102085|RGD:15090838
Cellular Component	GO:0016323	basolateral plasma membrane	Slc4a8	IDA		Mouse	MGI:MGI:7339318|PMID:30355950
Cellular Component	GO:0016323	basolateral plasma membrane	Slc4a8	IDA		Rat	PMID:18359573|RGD:155230773
Cellular Component	GO:0030425	dendrite	SLC4A8	IDA		Human	PMID:17715183
Cellular Component	GO:0097386	glial cell projection	Slc4a8	IDA		Rat	PMID:22102085|RGD:15090838
Cellular Component	GO:0098978	glutamatergic synapse	Slc4a8	IDA		Mouse	MGI:MGI:5013899|PMID:21593314
Cellular Component	GO:0098978	glutamatergic synapse	Slc4a8	IDA		Rat	PMID:22102085|RGD:15090838
Cellular Component	GO:0097457	hippocampal mossy fiber	Slc4a8	IDA		Rat	PMID:22102085|RGD:15090838
Cellular Component	GO:0016020	membrane	Slc4a8	IDA		Mouse	PMID:18359573
Cellular Component	GO:0043005	neuron projection	Slc4a8	IDA		Mouse	PMID:18359573
Cellular Component	GO:0043005	neuron projection	Slc4a8	IDA		Rat	PMID:22102085|RGD:15090838
Cellular Component	GO:0032809	neuronal cell body membrane	Slc4a8	IDA		Mouse	PMID:18359573
Cellular Component	GO:0005886	plasma membrane	Slc4a8	IDA		Mouse	PMID:23500099
Cellular Component	GO:0005886	plasma membrane	Slc4a8	IDA		Mouse	PMID:18359573
Cellular Component	GO:0005886	plasma membrane	Slc4a8	IDA		Rat	PMID:18359573|RGD:155230773
Cellular Component	GO:0005886	plasma membrane	Slc4a8	IMP		Rat	PMID:34584093|RGD:155230735
Cellular Component	GO:0005886	plasma membrane	Slc4a8	IDA		Rat	PMID:17715183|RGD:15090851
Cellular Component	GO:0098793	presynapse	Slc4a8	IDA		Mouse	MGI:MGI:5013899|PMID:21593314
Cellular Component	GO:0098793	presynapse	Slc4a8	IDA		Rat	PMID:22102085|RGD:15090838
Cellular Component	GO:0042734	presynaptic membrane	Slc4a8	IDA		Mouse	MGI:MGI:5013899|PMID:21593314
Cellular Component	GO:0032280	symmetric synapse	Slc4a8	IDA		Rat	PMID:22102085|RGD:15090838
Cellular Component	GO:0008021	synaptic vesicle	Slc4a8	IDA		Rat	PMID:22102085|RGD:15090838
Cellular Component	GO:0030672	synaptic vesicle membrane	Slc4a8	IDA		Rat	PMID:22102085|RGD:15090838
Cellular Component	GO:0043195	terminal bouton	Slc4a8	IDA		Rat	PMID:22102085|RGD:15090838
Biological Process	GO:0110010	basolateral protein secretion	Slc4a8	IDA		Rat	PMID:21195699|RGD:155230722
Biological Process	GO:0015701	bicarbonate transport	SLC4A8	IDA		Human	PMID:11133997
Biological Process	GO:1902476	chloride transmembrane transport	SLC4A8	IDA		Human	PMID:11133997
Biological Process	GO:0009790	embryo development	Slc4a8	IMP		Mouse	PMID:23677982
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Slc4a8	IMP		Mouse	MGI:MGI:5013899|PMID:21593314
Biological Process	GO:2000302	positive regulation of synaptic vesicle exocytosis	Slc4a8	IMP		Mouse	MGI:MGI:5013899|PMID:21593314
Biological Process	GO:0051453	regulation of intracellular pH	SLC4A8	IDA		Human	PMID:11133997
Biological Process	GO:0051453	regulation of intracellular pH	SLC4A8	IDA		Human	PMID:18577713
Biological Process	GO:0051453	regulation of intracellular pH	Slc4a8	IMP		Mouse	MGI:MGI:5013899|PMID:21593314
Biological Process	GO:0051453	regulation of intracellular pH	Slc4a8	IDA		Rat	PMID:8189393|RGD:155230769
Biological Process	GO:0042391	regulation of membrane potential	SLC4A8	IDA		Human	PMID:11133997
Biological Process	GO:0042391	regulation of membrane potential	SLC4A8	IDA		Human	PMID:18577713
Biological Process	GO:0035725	sodium ion transmembrane transport	SLC4A8	IDA		Human	PMID:11133997

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern