Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC5A3
  • Mouse genes Slc5a3
  • Rat genes
  • Zfish genes slc5a3a,slc5a3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc5a3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005367	myo-inositol:sodium symporter activity	SLC5A3	IDA		Human	PMID:24595108
Molecular Function	GO:0015459	potassium channel regulator activity	SLC5A3	IDA		Human	PMID:28793216
Molecular Function	GO:0005515	protein binding	SLC5A3	IPI	UniProtKB:P51787	Human	PMID:24595108
Molecular Function	GO:0005515	protein binding	Slc5a3	IPI	UniProtKB:P97414	Mouse	PMID:24595108
Molecular Function	GO:0005515	protein binding	Slc5a3	IPI	UniProtKB:Q9D808	Mouse	PMID:24595108
Molecular Function	GO:0044325	transmembrane transporter binding	SLC5A3	IPI	UniProtKB:O43526	Human	PMID:28793216
Cellular Component	GO:0016324	apical plasma membrane	Slc5a3	IDA		Mouse	MGI:MGI:6142178|PMID:24595108
Cellular Component	GO:0016323	basolateral plasma membrane	Slc5a3	IDA		Mouse	MGI:MGI:6142178|PMID:24595108
Cellular Component	GO:0048471	perinuclear region of cytoplasm	SLC5A3	IDA		Human	PMID:25756525
Cellular Component	GO:0005886	plasma membrane	SLC5A3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SLC5A3	IDA		Human	PMID:25756525
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Slc5a3	IDA		Mouse	PMID:24595108
Biological Process	GO:0006020	inositol metabolic process	Slc5a3	IMP	MGI:MGI:2663787	Mouse	PMID:18675571
Biological Process	GO:0006020	inositol metabolic process	Slc5a3	IMP	MGI:MGI:2663787	Mouse	PMID:16644257
Biological Process	GO:0015798	myo-inositol transport	Slc5a3	IMP	MGI:MGI:2663787	Mouse	PMID:12582158
Biological Process	GO:0015798	myo-inositol transport	Slc5a3	IMP	MGI:MGI:3609547	Mouse	PMID:16174787
Biological Process	GO:0007422	peripheral nervous system development	Slc5a3	IMP	MGI:MGI:3609547	Mouse	PMID:16174787
Biological Process	GO:0043085	positive regulation of catalytic activity	Slc5a3	IMP		Mouse	MGI:MGI:6414721|PMID:28128227
Biological Process	GO:1905477	positive regulation of protein localization to membrane	Slc5a3	IMP		Mouse	MGI:MGI:6414721|PMID:28128227
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	Slc5a3	IMP		Mouse	MGI:MGI:6414721|PMID:28128227
Biological Process	GO:0043576	regulation of respiratory gaseous exchange	Slc5a3	IMP	MGI:MGI:2663787	Mouse	PMID:12582158
Biological Process	GO:0032409	regulation of transporter activity	Slc5a3	IDA		Mouse	PMID:24595108

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern