Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC6A1
  • Mouse genes Slc6a1
  • Rat genes Slc6a1
  • Zfish genes slc6a1a,slc6a1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc6a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005283	amino acid:sodium symporter activity	Slc6a1	IDA		Mouse	MGI:MGI:7275316|PMID:30270321
Molecular Function	GO:0015185	gamma-aminobutyric acid transmembrane transporter activity	Slc6a1	IMP		Mouse	MGI:MGI:6415648|PMID:15106822
Molecular Function	GO:0005332	gamma-aminobutyric acid:sodium:chloride symporter activity	SLC6A1	IDA		Human	PMID:10973981
Molecular Function	GO:0005332	gamma-aminobutyric acid:sodium:chloride symporter activity	SLC6A1	IMP		Human	PMID:30132828
Molecular Function	GO:0005332	gamma-aminobutyric acid:sodium:chloride symporter activity	Slc6a1	IDA		Mouse	MGI:MGI:7275316|PMID:30270321
Molecular Function	GO:0005332	gamma-aminobutyric acid:sodium:chloride symporter activity	Slc6a1	IDA		Mouse	MGI:MGI:7275321|PMID:16150932
Molecular Function	GO:0005332	gamma-aminobutyric acid:sodium:chloride symporter activity	Slc6a1	IDA		Mouse	MGI:MGI:52213|PMID:8420981
Molecular Function	GO:0005332	gamma-aminobutyric acid:sodium:chloride symporter activity	Slc6a1	IDA		Rat	PMID:18054861|RGD:152025510
Molecular Function	GO:0005332	gamma-aminobutyric acid:sodium:chloride symporter activity	Slc6a1	IDA		Rat	PMID:1975955|RGD:632739
Molecular Function	GO:0005332	gamma-aminobutyric acid:sodium:chloride symporter activity	Slc6a1	IDA		Rat	PMID:21775701|RGD:152025506
Molecular Function	GO:0042802	identical protein binding	Slc6a1	IPI	RGD:620533	Rat	PMID:16314925|RGD:1643201
Molecular Function	GO:0005515	protein binding	SLC6A1	IPI	UniProtKB:O75031	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Slc6a1	IPI	RGD:69430	Rat	PMID:11017172|RGD:4891372
Molecular Function	GO:0015378	sodium:chloride symporter activity	SLC6A1	IDA		Human	PMID:10973981
Cellular Component	GO:0030424	axon	Slc6a1	IDA		Mouse	MGI:MGI:6415648|PMID:15106822
Cellular Component	GO:0030424	axon	Slc6a1	IDA		Mouse	MGI:MGI:3785041|PMID:11742587
Cellular Component	GO:0030424	axon	Slc6a1	IDA		Mouse	PMID:15479642
Cellular Component	GO:0009986	cell surface	Slc6a1	IDA		Rat	PMID:14500747|RGD:1643212
Cellular Component	GO:0098982	GABA-ergic synapse	Slc6a1	IMP		Mouse	PMID:12815026
Cellular Component	GO:0098982	GABA-ergic synapse	Slc6a1	IDA		Mouse	PMID:12815026
Cellular Component	GO:0098982	GABA-ergic synapse	Slc6a1	IDA		Rat	PMID:24368619|RGD:13702342
Cellular Component	GO:0098982	GABA-ergic synapse	Slc6a1	IDA		Rat	PMID:25120439|RGD:13702462
Cellular Component	GO:0043005	neuron projection	Slc6a1	IDA		Rat	PMID:15149801|RGD:1643208
Cellular Component	GO:0043025	neuronal cell body	Slc6a1	IDA		Mouse	MGI:MGI:3785041|PMID:11742587
Cellular Component	GO:0005886	plasma membrane	SLC6A1	IDA		Human	PMID:10973981
Cellular Component	GO:0005886	plasma membrane	Slc6a1	IDA		Mouse	PMID:17724084
Cellular Component	GO:0005886	plasma membrane	Slc6a1	IDA		Rat	PMID:16378241|RGD:1643199
Cellular Component	GO:0045211	postsynaptic membrane	Slc6a1	IDA		Rat	PMID:24368619|RGD:13702342
Cellular Component	GO:0042734	presynaptic membrane	Slc6a1	IDA		Rat	PMID:24368619|RGD:13702342
Cellular Component	GO:0042734	presynaptic membrane	Slc6a1	IDA		Rat	PMID:25120439|RGD:13702462
Biological Process	GO:0008306	associative learning	Slc6a1	IMP		Mouse	MGI:MGI:6415648|PMID:15106822
Biological Process	GO:0008306	associative learning	Slc6a1	IMP		Mouse	MGI:MGI:3785041|PMID:11742587
Biological Process	GO:1902476	chloride transmembrane transport	SLC6A1	IDA		Human	PMID:10973981
Biological Process	GO:0051939	gamma-aminobutyric acid import	SLC6A1	IDA		Human	PMID:10973981
Biological Process	GO:0051939	gamma-aminobutyric acid import	Slc6a1	IMP		Mouse	MGI:MGI:6415648|PMID:15106822
Biological Process	GO:0051939	gamma-aminobutyric acid import	Slc6a1	IDA		Rat	PMID:16378241|RGD:1643199
Biological Process	GO:0098658	inorganic anion import across plasma membrane	SLC6A1	IDA		Human	PMID:10973981
Biological Process	GO:0007612	learning	Slc6a1	IMP		Rat	PMID:12110474|RGD:1643216
Biological Process	GO:0007613	memory	Slc6a1	IMP		Mouse	MGI:MGI:6415648|PMID:15106822
Biological Process	GO:0007613	memory	Slc6a1	IMP		Mouse	MGI:MGI:3785041|PMID:11742587
Biological Process	GO:0032229	negative regulation of synaptic transmission, GABAergic	Slc6a1	IMP		Rat	PMID:17317750|RGD:1643193
Biological Process	GO:0098810	neurotransmitter reuptake	Slc6a1	IDA		Mouse	PMID:12815026
Biological Process	GO:0098810	neurotransmitter reuptake	Slc6a1	IMP		Mouse	PMID:12815026
Biological Process	GO:0098810	neurotransmitter reuptake	Slc6a1	IDA		Rat	PMID:1975955|RGD:632739
Biological Process	GO:0098810	neurotransmitter reuptake	Slc6a1	IMP		Rat	PMID:1975955|RGD:632739
Biological Process	GO:0014054	positive regulation of gamma-aminobutyric acid secretion	Slc6a1	IMP		Rat	PMID:14500747|RGD:1643212
Biological Process	GO:0051592	response to calcium ion	Slc6a1	IEP		Rat	PMID:15778221|RGD:1643203
Biological Process	GO:0042220	response to cocaine	Slc6a1	IEP		Rat	PMID:12832547|RGD:1643213
Biological Process	GO:0032355	response to estradiol	Slc6a1	IEP		Rat	PMID:15664431|RGD:1643204
Biological Process	GO:0010035	response to inorganic substance	SLC6A1	IDA		Human	PMID:10973981
Biological Process	GO:0010288	response to lead ion	Slc6a1	IEP		Rat	PMID:15149801|RGD:1643208
Biological Process	GO:0014070	response to organic cyclic compound	Slc6a1	IEP		Rat	PMID:17408599|RGD:1643196
Biological Process	GO:0010033	response to organic substance	Slc6a1	IMP		Rat	PMID:14980730|RGD:1643210
Biological Process	GO:0010243	response to organonitrogen compound	Slc6a1	IEP		Rat	PMID:17991494|RGD:1643192
Biological Process	GO:0014074	response to purine-containing compound	Slc6a1	IMP		Rat	PMID:16730753|RGD:1643197
Biological Process	GO:0009744	response to sucrose	Slc6a1	IEP		Rat	PMID:15778221|RGD:1643203
Biological Process	GO:0009636	response to toxic substance	Slc6a1	IEP		Rat	PMID:14500747|RGD:1643212
Biological Process	GO:0009636	response to toxic substance	Slc6a1	IMP		Rat	PMID:14643747|RGD:1643211
Biological Process	GO:0098719	sodium ion import across plasma membrane	SLC6A1	IDA		Human	PMID:10973981
Biological Process	GO:0050808	synapse organization	Slc6a1	IMP		Mouse	MGI:MGI:3785041|PMID:11742587

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern