Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC6A2
  • Mouse genes Slc6a2
  • Rat genes Slc6a2
  • Zfish genes slc6a2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc6a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	SLC6A2	IPI	UniProtKB:P60709	Human	PMID:18331289
Molecular Function	GO:0043014	alpha-tubulin binding	Slc6a2	IDA		Rat	PMID:18800064|RGD:6218960
Molecular Function	GO:0048487	beta-tubulin binding	Slc6a2	IDA		Rat	PMID:18800064|RGD:6218960
Molecular Function	GO:0005330	dopamine:sodium symporter activity	SLC6A2	IDA		Human	PMID:11093780
Molecular Function	GO:0005330	dopamine:sodium symporter activity	SLC6A2	IDA		Human	PMID:8125921
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	SLC6A2	IDA		Human	PMID:16024787
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	Slc6a2	IMP		Mouse	MGI:MGI:6436398|PMID:20858707
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	Slc6a2	IMP		Mouse	MGI:MGI:6436398|PMID:20858707
Molecular Function	GO:0005334	norepinephrine:sodium symporter activity	SLC6A2	IDA		Human	PMID:2008212
Molecular Function	GO:0005334	norepinephrine:sodium symporter activity	SLC6A2	IDA		Human	PMID:8125921
Molecular Function	GO:0005334	norepinephrine:sodium symporter activity	Slc6a2	IDA		Mouse	MGI:MGI:3834965|PMID:16269905
Molecular Function	GO:0005334	norepinephrine:sodium symporter activity	Slc6a2	IDA		Rat	PMID:10196144|RGD:634151
Molecular Function	GO:0005515	protein binding	SLC6A2	IPI	UniProtKB:Q9NRD5	Human	PMID:11343649
Molecular Function	GO:0005515	protein binding	SLC6A2	IPI	UniProtKB:P37840	Human	PMID:17156375
Molecular Function	GO:0005515	protein binding	SLC6A2	IPI	UniProtKB:P37840	Human	PMID:18331289
Molecular Function	GO:0005515	protein binding	Slc6a2	IPI	RGD:3729	Rat	PMID:18800064|RGD:6218960
Molecular Function	GO:0005515	protein binding	Slc6a2	IPI	RGD:70996	Rat	PMID:18800064|RGD:6218960
Cellular Component	GO:0009986	cell surface	Slc6a2	IDA		Rat	PMID:14976208|RGD:1624281
Cellular Component	GO:0045121	membrane raft	Slc6a2	IDA		Rat	PMID:14976208|RGD:1624281
Cellular Component	GO:0043005	neuron projection	Slc6a2	IDA		Rat	PMID:18800064|RGD:6218960
Cellular Component	GO:0005886	plasma membrane	SLC6A2	IDA		Human	PMID:11343649
Cellular Component	GO:0005886	plasma membrane	Slc6a2	IDA		Rat	PMID:18800064|RGD:6218960
Cellular Component	GO:0098793	presynapse	Slc6a2	IDA		Mouse	MGI:MGI:1355627|PMID:10769386
Biological Process	GO:0015844	monoamine transport	SLC6A2	IDA		Human	PMID:16024787
Biological Process	GO:0098810	neurotransmitter reuptake	Slc6a2	IDA		Mouse	PMID:10769386
Biological Process	GO:0098810	neurotransmitter reuptake	Slc6a2	IMP		Mouse	PMID:10769386
Biological Process	GO:0006836	neurotransmitter transport	Slc6a2	IMP		Mouse	MGI:MGI:6436398|PMID:20858707
Biological Process	GO:0006836	neurotransmitter transport	Slc6a2	IDA		Mouse	PMID:11805341
Biological Process	GO:0015874	norepinephrine transport	Slc6a2	IDA		Rat	PMID:10196144|RGD:634151
Biological Process	GO:0051620	norepinephrine uptake	Slc6a2	IMP		Mouse	MGI:MGI:6436398|PMID:20858707
Biological Process	GO:0048265	response to pain	Slc6a2	IMP		Mouse	PMID:11805341
Biological Process	GO:0009410	response to xenobiotic stimulus	Slc6a2	IEP		Rat	PMID:18800064|RGD:6218960

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern