Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Slc6a3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SLC6A3
- Mouse genes Slc6a3
- Rat genes Slc6a3
- Zfish genes slc6a3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc6a3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043176	amine binding	Slc6a3	IDA		Rat	PMID:15763134\|RGD:1625661
Molecular Function	GO:0043176	amine binding	Slc6a3	IPI	CHEBI:177883	Rat	PMID:15763134\|RGD:1625661
Molecular Function	GO:0035240	dopamine binding	Slc6a3	IDA		Mouse	PMID:18671743
Molecular Function	GO:0005330	dopamine:sodium symporter activity	SLC6A3	IDA		Human	PMID:10375632
Molecular Function	GO:0005330	dopamine:sodium symporter activity	SLC6A3	IDA		Human	PMID:11093780
Molecular Function	GO:0005330	dopamine:sodium symporter activity	SLC6A3	IDA		Human	PMID:1406597
Molecular Function	GO:0005330	dopamine:sodium symporter activity	SLC6A3	IDA		Human	PMID:15505207
Molecular Function	GO:0005330	dopamine:sodium symporter activity	SLC6A3	IMP		Human	PMID:19478460
Molecular Function	GO:0005330	dopamine:sodium symporter activity	SLC6A3	IDA		Human	PMID:8302271
Molecular Function	GO:0005330	dopamine:sodium symporter activity	Slc6a3	IDA		Mouse	MGI:MGI:1340648\|PMID:10375632
Molecular Function	GO:0005330	dopamine:sodium symporter activity	Slc6a3	IMP	MGI:MGI:2386303	Mouse	PMID:9520487
Molecular Function	GO:0005330	dopamine:sodium symporter activity	Slc6a3	IMP		Rat	PMID:1502198\|RGD:152995550
Molecular Function	GO:0005330	dopamine:sodium symporter activity	Slc6a3	IDA		Rat	PMID:1765147\|RGD:730166
Molecular Function	GO:0005330	dopamine:sodium symporter activity	Slc6a3	IDA		Rat	PMID:1948034\|RGD:730247
Molecular Function	GO:0005330	dopamine:sodium symporter activity	Slc6a3	IDA		Rat	PMID:1948035\|RGD:730214
Molecular Function	GO:0005330	dopamine:sodium symporter activity	Slc6a3	IDA		Rat	PMID:20412389\|RGD:4139887
Molecular Function	GO:0005330	dopamine:sodium symporter activity	Slc6a3	IDA		Rat	PMID:8125921\|RGD:152995566
Molecular Function	GO:1901363	heterocyclic compound binding	Slc6a3	IPI	CHEBI:177884\|CHEBI:177885	Rat	PMID:15763134\|RGD:1625661
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	SLC6A3	IDA		Human	PMID:16024787
Molecular Function	GO:0008504	monoamine transmembrane transporter activity	Slc6a3	IMP		Mouse	MGI:MGI:6436398\|PMID:20858707
Molecular Function	GO:0005326	neurotransmitter transmembrane transporter activity	Slc6a3	IMP		Mouse	MGI:MGI:6436398\|PMID:20858707
Molecular Function	GO:0005334	norepinephrine:sodium symporter activity	Slc6a3	IDA		Rat	PMID:8125921\|RGD:152995566
Molecular Function	GO:0002020	protease binding	Slc6a3	IPI	RGD:2394	Rat	PMID:19419578\|RGD:6483104
Molecular Function	GO:0005515	protein binding	SLC6A3	IPI	UniProtKB:Q9NRD5	Human	PMID:11343649
Molecular Function	GO:0005515	protein binding	SLC6A3	IPI	UniProtKB:P37840	Human	PMID:12958153
Molecular Function	GO:0005515	protein binding	SLC6A3	IPI	UniProtKB:O14656	Human	PMID:15505207
Molecular Function	GO:0005515	protein binding	SLC6A3	IPI	UniProtKB:P14416	Human	PMID:17380124
Molecular Function	GO:0005515	protein binding	SLC6A3	IPI	UniProtKB:O15354	Human	PMID:17519329
Molecular Function	GO:0005515	protein binding	SLC6A3	IPI	UniProtKB:Q9EP80	Human	PMID:20018661
Molecular Function	GO:0005515	protein binding	SLC6A3	IPI	UniProtKB:Q5BJQ5	Human	PMID:21957239
Molecular Function	GO:0005515	protein binding	SLC6A3	IPI	UniProtKB:Q99578	Human	PMID:21957239
Molecular Function	GO:0005515	protein binding	SLC6A3	IPI	UniProtKB:P37840	Human	PMID:22163275
Molecular Function	GO:0005515	protein binding	SLC6A3	IPI	UniProtKB:Q5T9L3	Human	PMID:28734904
Molecular Function	GO:0005515	protein binding	Slc6a3	IPI	UniProtKB:P28661	Mouse	MGI:MGI:3796969\|PMID:17296554
Molecular Function	GO:0005515	protein binding	Slc6a3	IPI	UniProtKB:Q8R191	Mouse	MGI:MGI:3840716\|PMID:19357284
Molecular Function	GO:0005515	protein binding	Slc6a3	IPI	UniProtKB:O55042\|UniProtKB:P37840	Mouse	MGI:MGI:5516183\|PMID:22163275
Molecular Function	GO:0051721	protein phosphatase 2A binding	Slc6a3	IPI	RGD:3380	Rat	PMID:20035724\|RGD:8693589
Molecular Function	GO:0044877	protein-containing complex binding	Slc6a3	IDA		Rat	PMID:15056723\|RGD:1625667
Molecular Function	GO:0005102	signaling receptor binding	Slc6a3	IPI	RGD:2520	Rat	PMID:18256931\|RGD:2311568
Cellular Component	GO:0030424	axon	SLC6A3	IDA		Human	PMID:12958153
Cellular Component	GO:0030424	axon	Slc6a3	IDA		Mouse	PMID:17761882
Cellular Component	GO:0043679	axon terminus	Slc6a3	IDA		Mouse	MGI:MGI:3796969\|PMID:17296554
Cellular Component	GO:0009986	cell surface	SLC6A3	IDA		Human	PMID:21399631
Cellular Component	GO:0009986	cell surface	Slc6a3	IDA		Mouse	MGI:MGI:5634885\|PMID:21399631
Cellular Component	GO:0098691	dopaminergic synapse	Slc6a3	IDA		Rat	PMID:8551328\|RGD:13702275
Cellular Component	GO:0016600	flotillin complex	SLC6A3	IDA		Human	PMID:21399631
Cellular Component	GO:0016020	membrane	Slc6a3	IDA		Rat	PMID:15763134\|RGD:1625661
Cellular Component	GO:0045121	membrane raft	SLC6A3	IDA		Human	PMID:21957239
Cellular Component	GO:0043005	neuron projection	SLC6A3	IDA		Human	PMID:21957239
Cellular Component	GO:0043005	neuron projection	Slc6a3	IDA		Rat	PMID:15234104\|RGD:1625664
Cellular Component	GO:0043005	neuron projection	Slc6a3	IDA		Rat	PMID:20412389\|RGD:4139887
Cellular Component	GO:0043005	neuron projection	Slc6a3	IDA		Rat	PMID:32963038\|RGD:127285397
Cellular Component	GO:0043025	neuronal cell body	SLC6A3	IDA		Human	PMID:12958153
Cellular Component	GO:0005886	plasma membrane	SLC6A3	IDA		Human	PMID:11343649
Cellular Component	GO:0005886	plasma membrane	SLC6A3	IDA		Human	PMID:12958153
Cellular Component	GO:0005886	plasma membrane	SLC6A3	IDA		Human	PMID:15505207
Cellular Component	GO:0005886	plasma membrane	SLC6A3	IDA		Human	PMID:21957239
Cellular Component	GO:0005886	plasma membrane	Slc6a3	IDA		Rat	PMID:14681933\|RGD:1580024
Cellular Component	GO:0005886	plasma membrane	Slc6a3	IDA		Rat	PMID:21399631\|RGD:10047184
Cellular Component	GO:0045211	postsynaptic membrane	Slc6a3	IDA		Rat	PMID:8551328\|RGD:13702275
Cellular Component	GO:0042734	presynaptic membrane	Slc6a3	IDA		Rat	PMID:8551328\|RGD:13702275
Biological Process	GO:0021984	adenohypophysis development	Slc6a3	IMP	MGI:MGI:2386303	Mouse	PMID:9247269
Biological Process	GO:0007568	aging	Slc6a3	IEP		Rat	PMID:14643386\|RGD:1625669
Biological Process	GO:0042416	dopamine biosynthetic process	Slc6a3	IMP	MGI:MGI:2386303	Mouse	PMID:9520487
Biological Process	GO:0042420	dopamine catabolic process	Slc6a3	IMP	MGI:MGI:2386303	Mouse	PMID:9520487
Biological Process	GO:0015872	dopamine transport	SLC6A3	IDA		Human	PMID:15505207
Biological Process	GO:0015872	dopamine transport	Slc6a3	IMP	MGI:MGI:2386303	Mouse	PMID:9520487
Biological Process	GO:0015872	dopamine transport	Slc6a3	IDA		Rat	PMID:1765147\|RGD:730166
Biological Process	GO:0015872	dopamine transport	Slc6a3	IDA		Rat	PMID:20412389\|RGD:4139887
Biological Process	GO:0090494	dopamine uptake	SLC6A3	IDA		Human	PMID:21957239
Biological Process	GO:0090494	dopamine uptake	Slc6a3	IMP		Mouse	MGI:MGI:6436398\|PMID:20858707
Biological Process	GO:1990384	hyaloid vascular plexus regression	Slc6a3	IDA		Mouse	MGI:MGI:6359287\|PMID:30936473
Biological Process	GO:0007595	lactation	Slc6a3	IMP	MGI:MGI:2386303	Mouse	PMID:9247269
Biological Process	GO:0007626	locomotory behavior	Slc6a3	IMP	MGI:MGI:2386303	Mouse	PMID:11150348
Biological Process	GO:0007626	locomotory behavior	Slc6a3	IGI	MGI:MGI:99578	Mouse	PMID:11150348
Biological Process	GO:0007626	locomotory behavior	Slc6a3	IGI	MGI:MGI:94924	Mouse	PMID:11150348
Biological Process	GO:0015844	monoamine transport	SLC6A3	IDA		Human	PMID:16024787
Biological Process	GO:0006836	neurotransmitter transport	Slc6a3	IMP		Mouse	MGI:MGI:6436398\|PMID:20858707
Biological Process	GO:0001504	neurotransmitter uptake	Slc6a3	IMP		Mouse	PMID:8628395
Biological Process	GO:0001504	neurotransmitter uptake	Slc6a3	IDA		Mouse	PMID:8628395
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Slc6a3	IMP	MGI:MGI:2386303	Mouse	PMID:9247269
Biological Process	GO:0060134	prepulse inhibition	Slc6a3	IMP	MGI:MGI:2386303	Mouse	PMID:11150348
Biological Process	GO:0042053	regulation of dopamine metabolic process	Slc6a3	IMP	MGI:MGI:2386303	Mouse	PMID:9520487
Biological Process	GO:0042053	regulation of dopamine metabolic process	Slc6a3	IMP	MGI:MGI:2386303	Mouse	PMID:9247269
Biological Process	GO:0051591	response to cAMP	Slc6a3	IDA		Rat	PMID:15234104\|RGD:1625664
Biological Process	GO:0042220	response to cocaine	Slc6a3	IDA		Mouse	PMID:18671743
Biological Process	GO:0045471	response to ethanol	Slc6a3	IDA		Rat	PMID:15897718\|RGD:1625659
Biological Process	GO:0010039	response to iron ion	Slc6a3	IEP		Rat	PMID:12672939\|RGD:1625670
Biological Process	GO:0035094	response to nicotine	Slc6a3	IEP		Rat	PMID:15157990\|RGD:1625665
Biological Process	GO:0014070	response to organic cyclic compound	Slc6a3	IEP		Rat	PMID:12541010\|RGD:1625654
Biological Process	GO:0009410	response to xenobiotic stimulus	Slc6a3	IEP		Rat	PMID:15992364\|RGD:1625658
Biological Process	GO:0007608	sensory perception of smell	Slc6a3	IMP	MGI:MGI:2386303	Mouse	PMID:16765459

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.