Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Slc6a6

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SLC6A6
- Mouse genes Slc6a6
- Rat genes Slc6a6
- Zfish genes slc6a6a,slc6a6b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc6a6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0022858	alanine transmembrane transporter activity	SLC6A6	IDA		Human	PMID:19074966
Molecular Function	GO:0015171	amino acid transmembrane transporter activity	SLC6A6	IDA		Human	PMID:24842606
Molecular Function	GO:0005283	amino acid:sodium symporter activity	SLC6A6	IDA		Human	PMID:8010975
Molecular Function	GO:0005283	amino acid:sodium symporter activity	Slc6a6	IDA		Mouse	MGI:MGI:51988\|PMID:1465453
Molecular Function	GO:0005283	amino acid:sodium symporter activity	Slc6a6	IDA		Mouse	MGI:MGI:7275316\|PMID:30270321
Molecular Function	GO:0005283	amino acid:sodium symporter activity	Slc6a6	IDA		Mouse	MGI:MGI:1099585\|PMID:9375654
Molecular Function	GO:0001761	beta-alanine transmembrane transporter activity	Slc6a6	IDA		Mouse	MGI:MGI:51986
Molecular Function	GO:0015185	gamma-aminobutyric acid transmembrane transporter activity	Slc6a6	IDA		Rat	PMID:18501699\|RGD:30309916
Molecular Function	GO:0015185	gamma-aminobutyric acid transmembrane transporter activity	Slc6a6	IGI	UniProtKB:Q9JJ19	Rat	PMID:29491210\|RGD:21201269
Molecular Function	GO:0005332	gamma-aminobutyric acid:sodium:chloride symporter activity	Slc6a6	IDA		Mouse	MGI:MGI:7275316\|PMID:30270321
Molecular Function	GO:0005332	gamma-aminobutyric acid:sodium:chloride symporter activity	Slc6a6	IDA		Rat	PMID:18501699\|RGD:30309916
Molecular Function	GO:0005515	protein binding	Slc6a6	IPI	UniProtKB:Q9JJ19	Rat	PMID:29491210\|RGD:21201269
Molecular Function	GO:0030977	taurine binding	Slc6a6	IDA		Rat	PMID:1435737\|RGD:61757
Molecular Function	GO:0005368	taurine transmembrane transporter activity	SLC6A6	IDA		Human	PMID:19074966
Molecular Function	GO:0005368	taurine transmembrane transporter activity	SLC6A6	IMP		Human	PMID:23519128
Molecular Function	GO:0005368	taurine transmembrane transporter activity	SLC6A6	IDA		Human	PMID:31903486
Molecular Function	GO:0005368	taurine transmembrane transporter activity	Slc6a6	IDA		Mouse	PMID:9375654
Molecular Function	GO:0005368	taurine transmembrane transporter activity	Slc6a6	IDA		Mouse	PMID:1465453
Molecular Function	GO:0005368	taurine transmembrane transporter activity	Slc6a6	IDA		Rat	PMID:18501699\|RGD:30309916
Molecular Function	GO:0005369	taurine:sodium symporter activity	SLC6A6	IMP		Human	PMID:31345061
Molecular Function	GO:0005369	taurine:sodium symporter activity	SLC6A6	IMP		Human	PMID:31903486
Molecular Function	GO:0005369	taurine:sodium symporter activity	SLC6A6	IDA		Human	PMID:8010975
Molecular Function	GO:0005369	taurine:sodium symporter activity	SLC6A6	IDA		Human	PMID:8382624
Molecular Function	GO:0005369	taurine:sodium symporter activity	SLC6A6	IDA		Human	PMID:8654117
Molecular Function	GO:0005369	taurine:sodium symporter activity	Slc6a6	IDA		Mouse	MGI:MGI:51988\|PMID:1465453
Molecular Function	GO:0005369	taurine:sodium symporter activity	Slc6a6	IDA		Mouse	MGI:MGI:7275316\|PMID:30270321
Molecular Function	GO:0005369	taurine:sodium symporter activity	Slc6a6	IDA		Mouse	MGI:MGI:1099585\|PMID:9375654
Molecular Function	GO:0005369	taurine:sodium symporter activity	Slc6a6	IDA		Rat	PMID:1435737\|RGD:61757
Molecular Function	GO:0005369	taurine:sodium symporter activity	Slc6a6	IDA		Rat	PMID:18501699\|RGD:30309916
Molecular Function	GO:0005369	taurine:sodium symporter activity	Slc6a6	IDA		Rat	PMID:22896705\|RGD:152025533
Molecular Function	GO:0005369	taurine:sodium symporter activity	slc6a6b	IDA		Zfish	PMID:18407297
Cellular Component	GO:0016324	apical plasma membrane	SLC6A6	IDA		Human	PMID:31791063
Cellular Component	GO:0016323	basolateral plasma membrane	SLC6A6	IDA		Human	PMID:31791063
Cellular Component	GO:0030425	dendrite	Slc6a6	IDA		Rat	PMID:25004465\|RGD:30309938
Cellular Component	GO:0098982	GABA-ergic synapse	Slc6a6	IDA		Mouse	PMID:12824447
Cellular Component	GO:0098982	GABA-ergic synapse	Slc6a6	IMP		Mouse	PMID:12824447
Cellular Component	GO:0098982	GABA-ergic synapse	Slc6a6	IDA		Mouse	PMID:17962336
Cellular Component	GO:0098982	GABA-ergic synapse	Slc6a6	IMP		Mouse	PMID:17962336
Cellular Component	GO:0031528	microvillus membrane	SLC6A6	IDA		Human	PMID:15166008
Cellular Component	GO:0043025	neuronal cell body	Slc6a6	IDA		Rat	PMID:25004465\|RGD:30309938
Cellular Component	GO:0005886	plasma membrane	SLC6A6	IDA		Human	PMID:31345061
Cellular Component	GO:0005886	plasma membrane	SLC6A6	IDA		Human	PMID:31903486
Cellular Component	GO:0005886	plasma membrane	SLC6A6	IDA		Human	PMID:28112518
Cellular Component	GO:0005886	plasma membrane	Slc6a6	IDA		Rat	PMID:18501699\|RGD:30309916
Cellular Component	GO:0005886	plasma membrane	Slc6a6	IDA		Rat	PMID:25004465\|RGD:30309938
Cellular Component	GO:0098797	plasma membrane protein complex	Slc6a6	IPI	UniProtKB:Q9JJ19	Rat	PMID:29491210\|RGD:21201269
Cellular Component	GO:0045211	postsynaptic membrane	Slc6a6	IDA		Mouse	PMID:17962336
Cellular Component	GO:0045211	postsynaptic membrane	Slc6a6	IMP		Mouse	PMID:17962336
Biological Process	GO:0032328	alanine transport	SLC6A6	IDA		Human	PMID:19074966
Biological Process	GO:0089718	amino acid import across plasma membrane	SLC6A6	IDA		Human	PMID:19074966
Biological Process	GO:0089718	amino acid import across plasma membrane	SLC6A6	IDA		Human	PMID:24842606
Biological Process	GO:0001762	beta-alanine transport	Slc6a6	IDA		Mouse	MGI:MGI:51986
Biological Process	GO:0051939	gamma-aminobutyric acid import	Slc6a6	IDA		Rat	PMID:18501699\|RGD:30309916
Biological Process	GO:0051939	gamma-aminobutyric acid import	Slc6a6	IGI	UniProtKB:Q9JJ19	Rat	PMID:29491210\|RGD:21201269
Biological Process	GO:0098739	import across plasma membrane	Slc6a6	IGI	UniProtKB:Q9JJ19	Rat	PMID:29491210\|RGD:21201269
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Slc6a6	IDA		Mouse	PMID:12824447
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Slc6a6	IMP		Mouse	PMID:12824447
Biological Process	GO:0071705	nitrogen compound transport	SLC6A6	IDA		Human	PMID:24842606
Biological Process	GO:1903825	organic acid transmembrane transport	slc6a6b	IDA		Zfish	PMID:18407297\|ZFIN:ZDB-PUB-080415-17
Biological Process	GO:0045597	positive regulation of cell differentiation	SLC6A6	IMP		Human	PMID:23519128
Biological Process	GO:0010940	positive regulation of necrotic cell death	SLC6A6	IDA		Human	PMID:24842606
Biological Process	GO:0035725	sodium ion transmembrane transport	slc6a6b	IDA		Zfish	PMID:18407297\|ZFIN:ZDB-PUB-080415-17
Biological Process	GO:0015734	taurine transport	SLC6A6	IDA		Human	PMID:19074966
Biological Process	GO:0015734	taurine transport	SLC6A6	IMP		Human	PMID:23519128
Biological Process	GO:0015734	taurine transport	SLC6A6	IDA		Human	PMID:31903486
Biological Process	GO:0015734	taurine transport	Slc6a6	IDA		Mouse	PMID:9375654
Biological Process	GO:0015734	taurine transport	Slc6a6	IDA		Mouse	PMID:1465453
Biological Process	GO:0015734	taurine transport	Slc6a6	IMP	MGI:MGI:2179132	Mouse	PMID:11772953
Biological Process	GO:0015734	taurine transport	Slc6a6	IMP		Rat	PMID:1435737\|RGD:61757
Biological Process	GO:0015734	taurine transport	Slc6a6	IDA		Rat	PMID:18501699\|RGD:30309916
Biological Process	GO:0015734	taurine transport	slc6a6b	IDA		Zfish	PMID:18407297\|ZFIN:ZDB-PUB-080415-17
Biological Process	GO:0015734	taurine transport	slc6a6b	IDA		Zfish	PMID:18407297
Biological Process	GO:0042908	xenobiotic transport	slc6a6b	IDA		Zfish	PMID:18407297\|ZFIN:ZDB-PUB-080415-17

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/15/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.