Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC6A8
  • Mouse genes Slc6a8
  • Rat genes Slc6a8
  • Zfish genes slc6a8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc6a8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015220	choline transmembrane transporter activity	Slc6a8	IDA		Rat	PMID:1633856|RGD:737698
Molecular Function	GO:0005308	creatine transmembrane transporter activity	Slc6a8	IDA		Rat	PMID:8297374|RGD:634748
Molecular Function	GO:0005309	creatine:sodium symporter activity	SLC6A8	IMP		Human	PMID:17465020
Molecular Function	GO:0005309	creatine:sodium symporter activity	SLC6A8	IMP		Human	PMID:22644605
Molecular Function	GO:0005309	creatine:sodium symporter activity	SLC6A8	IMP		Human	PMID:25861866
Molecular Function	GO:0005309	creatine:sodium symporter activity	SLC6A8	IDA		Human	PMID:7945388
Molecular Function	GO:0005309	creatine:sodium symporter activity	SLC6A8	IDA		Human	PMID:7953292
Molecular Function	GO:0005309	creatine:sodium symporter activity	SLC6A8	IDA		Human	PMID:9882430
Molecular Function	GO:0005309	creatine:sodium symporter activity	Slc6a8	IDA		Mouse	MGI:MGI:2661038|PMID:12439290
Molecular Function	GO:0005309	creatine:sodium symporter activity	Slc6a8	IDA		Rat	PMID:12069495|RGD:1359082
Molecular Function	GO:0005309	creatine:sodium symporter activity	Slc6a8	IDA		Rat	PMID:12433955|RGD:152995551
Molecular Function	GO:0005309	creatine:sodium symporter activity	Slc6a8	IDA		Rat	PMID:15702372|RGD:152995540
Molecular Function	GO:0005309	creatine:sodium symporter activity	Slc6a8	IDA		Rat	PMID:32115505|RGD:152995555
Molecular Function	GO:0005309	creatine:sodium symporter activity	Slc6a8	IDA		Rat	PMID:8297374|RGD:634748
Cellular Component	GO:0016324	apical plasma membrane	SLC6A8	IDA		Human	PMID:12433955
Cellular Component	GO:0016324	apical plasma membrane	Slc6a8	IDA		Rat	PMID:12433955|RGD:152995551
Cellular Component	GO:0016324	apical plasma membrane	Slc6a8	IDA		Rat	PMID:15702372|RGD:152995540
Cellular Component	GO:0098978	glutamatergic synapse	Slc6a8	IDA		Rat	PMID:20731764|RGD:13702397
Cellular Component	GO:0005886	plasma membrane	SLC6A8	IMP		Human	PMID:22644605
Cellular Component	GO:0005886	plasma membrane	Slc6a8	IDA		Rat	PMID:32115505|RGD:152995555
Cellular Component	GO:0045211	postsynaptic membrane	Slc6a8	IDA		Rat	PMID:20731764|RGD:13702397
Cellular Component	GO:0045202	synapse	Slc6a8	EXP		Rat	PMID:20731764|RGD:13702397
Cellular Component	GO:0045202	synapse	Slc6a8	IDA		Rat	PMID:20731764|RGD:13702397
Biological Process	GO:0015881	creatine transmembrane transport	SLC6A8	IMP		Human	PMID:25861866
Biological Process	GO:0015881	creatine transmembrane transport	Slc6a8	IDA		Rat	PMID:12069495|RGD:1359082
Biological Process	GO:0015881	creatine transmembrane transport	Slc6a8	IDA		Rat	PMID:8297374|RGD:634748
Biological Process	GO:1990403	embryonic brain development	Slc6a8	IEP		Rat	PMID:15918910|RGD:1599815
Biological Process	GO:0071705	nitrogen compound transport	SLC6A8	IDA		Human	PMID:24842606
Biological Process	GO:0030163	protein catabolic process	Slc6a8	EXP		Rat	PMID:20731764|RGD:13702397
Biological Process	GO:0030163	protein catabolic process	Slc6a8	IDA		Rat	PMID:20731764|RGD:13702397

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern