Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC7A11
  • Mouse genes Slc7a11
  • Rat genes Slc7a11
  • Zfish genes slc7a11
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc7a11

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015327	cystine:glutamate antiporter activity	SLC7A11	IDA		Human	PMID:11417227
Molecular Function	GO:0015327	cystine:glutamate antiporter activity	SLC7A11	IDA		Human	PMID:15151999
Molecular Function	GO:0015327	cystine:glutamate antiporter activity	SLC7A11	IDA		Human	PMID:34120018
Molecular Function	GO:0015327	cystine:glutamate antiporter activity	SLC7A11	IDA		Human	PMID:35245456
Molecular Function	GO:0015327	cystine:glutamate antiporter activity	SLC7A11	IDA		Human	PMID:35352032
Molecular Function	GO:0140926	L-kynurenine transmembrane transporter activity	SLC7A11	IDA		Human	PMID:35245456
Molecular Function	GO:0005515	protein binding	SLC7A11	IPI	UniProtKB:P16070	Human	PMID:21397861
Molecular Function	GO:0005515	protein binding	SLC7A11	IPI	UniProtKB:P08195-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A11	IPI	UniProtKB:Q07627	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A11	IPI	UniProtKB:Q8IUG1	Human	PMID:32296183
Cellular Component	GO:0045177	apical part of cell	Slc7a11	IDA		Mouse	PMID:16399997
Cellular Component	GO:0097449	astrocyte projection	Slc7a11	IDA		Mouse	PMID:16399997
Cellular Component	GO:0031526	brush border membrane	Slc7a11	IDA		Mouse	PMID:16399997
Cellular Component	GO:0009986	cell surface	SLC7A11	IDA		Human	PMID:25063885
Cellular Component	GO:0005856	cytoskeleton	Slc7a11	IDA		Rat	PMID:17401668|RGD:2315030
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Slc7a11	IDA		Rat	PMID:17401668|RGD:2315030
Cellular Component	GO:0016020	membrane	Slc7a11	IDA		Mouse	PMID:29350434
Cellular Component	GO:0005886	plasma membrane	SLC7A11	IDA		Human	PMID:11417227
Cellular Component	GO:0005886	plasma membrane	SLC7A11	IDA		Human	PMID:15151999
Cellular Component	GO:0005886	plasma membrane	SLC7A11	IPI	UniProtKB:P08195	Human	PMID:34880232
Cellular Component	GO:0005886	plasma membrane	Slc7a11	IDA		Mouse	PMID:16399997
Cellular Component	GO:0005886	plasma membrane	Slc7a11	IDA		Rat	PMID:17401668|RGD:2315030
Cellular Component	GO:0005791	rough endoplasmic reticulum	Slc7a11	IDA		Rat	PMID:17401668|RGD:2315030
Biological Process	GO:0030534	adult behavior	Slc7a11	IDA		Mouse	PMID:29024663
Biological Process	GO:0007420	brain development	Slc7a11	IMP	MGI:MGI:1857061	Mouse	PMID:17035536
Biological Process	GO:0007420	brain development	Slc7a11	IEP		Rat	PMID:17401668|RGD:2315030
Biological Process	GO:0034599	cellular response to oxidative stress	Slc7a11	IMP	MGI:MGI:1857061	Mouse	PMID:17035536
Biological Process	GO:0034599	cellular response to oxidative stress	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:23085521
Biological Process	GO:0034599	cellular response to oxidative stress	Slc7a11	IDA		Mouse	PMID:17035536
Biological Process	GO:0033554	cellular response to stress	Slc7a11	IDA		Mouse	PMID:29024663
Biological Process	GO:0140206	dipeptide import across plasma membrane	Slc7a11	IMP	MGI:MGI:1857061	Mouse	PMID:16037214
Biological Process	GO:0006749	glutathione metabolic process	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:17200146
Biological Process	GO:0006749	glutathione metabolic process	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:23085521
Biological Process	GO:0034775	glutathione transmembrane transport	Slc7a11	IDA		Mouse	PMID:17035536
Biological Process	GO:0090461	intracellular glutamate homeostasis	Slc7a11	IGI	MGI:MGI:1351339	Mouse	PMID:29024663
Biological Process	GO:0090461	intracellular glutamate homeostasis	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:21191088
Biological Process	GO:0015811	L-cystine transport	SLC7A11	IDA		Human	PMID:11133847
Biological Process	GO:0015811	L-cystine transport	SLC7A11	IDA		Human	PMID:11213471
Biological Process	GO:0015811	L-cystine transport	SLC7A11	IDA		Human	PMID:11417227
Biological Process	GO:0015811	L-cystine transport	SLC7A11	IDA		Human	PMID:15151999
Biological Process	GO:0015811	L-cystine transport	SLC7A11	IDA		Human	PMID:34880232
Biological Process	GO:0015811	L-cystine transport	SLC7A11	IDA		Human	PMID:35352032
Biological Process	GO:0015811	L-cystine transport	Slc7a11	IMP		Mouse	MGI:MGI:3588610|PMID:16037214
Biological Process	GO:0098712	L-glutamate import across plasma membrane	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:21490221
Biological Process	GO:0015813	L-glutamate transmembrane transport	SLC7A11	IDA		Human	PMID:11133847
Biological Process	GO:0015813	L-glutamate transmembrane transport	SLC7A11	IDA		Human	PMID:11417227
Biological Process	GO:0015813	L-glutamate transmembrane transport	SLC7A11	IDA		Human	PMID:15151999
Biological Process	GO:0015813	L-glutamate transmembrane transport	SLC7A11	IDA		Human	PMID:34880232
Biological Process	GO:0015813	L-glutamate transmembrane transport	SLC7A11	IDA		Human	PMID:35352032
Biological Process	GO:0140924	L-kynurenine transmembrane transport	SLC7A11	IDA		Human	PMID:35245456
Biological Process	GO:0070306	lens fiber cell differentiation	Slc7a11	IEP		Rat	PMID:16043861|RGD:2315033
Biological Process	GO:0060173	limb development	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:21490221
Biological Process	GO:0048286	lung alveolus development	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:23085521
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:25429150
Biological Process	GO:0110076	negative regulation of ferroptosis	SLC7A11	IDA		Human	PMID:35245456
Biological Process	GO:0071702	organic substance transport	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:16144837
Biological Process	GO:0071702	organic substance transport	Slc7a11	IMP	MGI:MGI:1857061	Mouse	PMID:16037214
Biological Process	GO:0071702	organic substance transport	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:17200146
Biological Process	GO:0070527	platelet aggregation	Slc7a11	IMP	MGI:MGI:1857061	Mouse	PMID:8699821
Biological Process	GO:1904717	regulation of AMPA glutamate receptor clustering	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:25429150
Biological Process	GO:0042127	regulation of cell population proliferation	Slc7a11	IMP	MGI:MGI:1857061	Mouse	PMID:17963724
Biological Process	GO:0042127	regulation of cell population proliferation	Slc7a11	IMP	MGI:MGI:1857061	Mouse	PMID:16037214
Biological Process	GO:0042127	regulation of cell population proliferation	Slc7a11	IMP	MGI:MGI:1857061	Mouse	PMID:17035536
Biological Process	GO:1900407	regulation of cellular response to oxidative stress	Slc7a11	IMP	MGI:MGI:1857061	Mouse	PMID:16037214
Biological Process	GO:1901494	regulation of cysteine metabolic process	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:17200146
Biological Process	GO:2000211	regulation of glutamate metabolic process	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:21490221
Biological Process	GO:2000211	regulation of glutamate metabolic process	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:25429150
Biological Process	GO:2000211	regulation of glutamate metabolic process	Slc7a11	IMP		Mouse	PMID:24548853
Biological Process	GO:1903786	regulation of glutathione biosynthetic process	Slc7a11	IMP	MGI:MGI:1857061	Mouse	PMID:16037214
Biological Process	GO:0048021	regulation of melanin biosynthetic process	Slc7a11	IMP	MGI:MGI:1857061	Mouse	PMID:16037214
Biological Process	GO:0033029	regulation of neutrophil apoptotic process	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:17200146
Biological Process	GO:0051223	regulation of protein transport	Slc7a11	IMP	MGI:MGI:1857061	Mouse	PMID:16037214
Biological Process	GO:0050807	regulation of synapse organization	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:25429150
Biological Process	GO:0035094	response to nicotine	Slc7a11	IEP		Rat	PMID:19103434|RGD:2315027
Biological Process	GO:0014070	response to organic cyclic compound	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:21191088
Biological Process	GO:0006979	response to oxidative stress	Slc7a11	IEP		Rat	PMID:16609915|RGD:2315032
Biological Process	GO:0051775	response to redox state	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:16144837
Biological Process	GO:0009636	response to toxic substance	SLC7A11	IDA		Human	PMID:17575980
Biological Process	GO:0021756	striatum development	Slc7a11	IMP	MGI:MGI:1857061	Mouse	PMID:17035536
Biological Process	GO:0021591	ventricular system development	Slc7a11	IMP	MGI:MGI:1857061	Mouse	PMID:17035536
Biological Process	GO:0008542	visual learning	Slc7a11	IMP		Mouse	PMID:24548853
Biological Process	GO:0008542	visual learning	Slc7a11	IMP	MGI:MGI:3608695	Mouse	PMID:21490221

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern