Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC7A8
  • Mouse genes Slc7a8
  • Rat genes Slc7a8
  • Zfish genes slc7a8a,slc7a8b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc7a8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015171	amino acid transmembrane transporter activity	SLC7A8	EXP		Human	PMID:10391915
Molecular Function	GO:0015171	amino acid transmembrane transporter activity	SLC7A8	IDA		Human	PMID:10391915
Molecular Function	GO:0015171	amino acid transmembrane transporter activity	SLC7A8	IDA		Human	PMID:10574970
Molecular Function	GO:0015171	amino acid transmembrane transporter activity	SLC7A8	IDA		Human	PMID:15918515
Molecular Function	GO:0015171	amino acid transmembrane transporter activity	SLC7A8	IDA		Human	PMID:26305885
Molecular Function	GO:0015187	glycine transmembrane transporter activity	Slc7a8	IMP		Mouse	MGI:MGI:6436375|PMID:32046769
Molecular Function	GO:0015180	L-alanine transmembrane transporter activity	SLC7A8	IGI	UniProtKB:P08195	Human	PMID:10391915
Molecular Function	GO:0015179	L-amino acid transmembrane transporter activity	Slc7a8	IDA		Mouse	PMID:15659399
Molecular Function	GO:0015190	L-leucine transmembrane transporter activity	SLC7A8	IGI	UniProtKB:P08195	Human	PMID:10391915
Molecular Function	GO:0015190	L-leucine transmembrane transporter activity	SLC7A8	IDA		Human	PMID:19075510
Molecular Function	GO:0015175	neutral L-amino acid transmembrane transporter activity	SLC7A8	IMP		Human	PMID:26050671
Molecular Function	GO:0015175	neutral L-amino acid transmembrane transporter activity	SLC7A8	IDA		Human	PMID:26305885
Molecular Function	GO:0015175	neutral L-amino acid transmembrane transporter activity	Slc7a8	IMP		Mouse	MGI:MGI:6436375|PMID:32046769
Molecular Function	GO:0015101	organic cation transmembrane transporter activity	SLC7A8	IDA		Human	PMID:12117417
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:P05362	Human	PMID:12716892
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:O15389	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:O60906	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:O95167	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:O95870	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:P08195-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:P21964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:P57105	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q6PI78	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q6UX34	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q96AG3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q96EC8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q96ES6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q9BRI3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q9BTX3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q9BUN8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q9GZY8-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q9H2L4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q9H6H4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q9NRZ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q9NZG7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q9Y548	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:O75460-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:P11021	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:P54652	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SLC7A8	IPI	UniProtKB:Q0VDC6	Human	PMID:32814053
Molecular Function	GO:0015349	thyroid hormone transmembrane transporter activity	SLC7A8	IDA		Human	PMID:26305885
Molecular Function	GO:0015349	thyroid hormone transmembrane transporter activity	Slc7a8	IMP		Mouse	MGI:MGI:4880788|PMID:21264952
Molecular Function	GO:0019534	toxin transmembrane transporter activity	SLC7A8	IDA		Human	PMID:12117417
Cellular Component	GO:0016324	apical plasma membrane	Slc7a8	IDA		Mouse	MGI:MGI:6436375|PMID:32046769
Cellular Component	GO:0009925	basal plasma membrane	SLC7A8	IDA		Human	PMID:26050671
Cellular Component	GO:0016323	basolateral plasma membrane	SLC7A8	IDA		Human	PMID:15918515
Cellular Component	GO:0031528	microvillus membrane	SLC7A8	IDA		Human	PMID:26050671
Cellular Component	GO:0005886	plasma membrane	SLC7A8	IDA		Human	PMID:10391915
Cellular Component	GO:0005886	plasma membrane	SLC7A8	IGI	UniProtKB:P08195	Human	PMID:10391915
Cellular Component	GO:0005886	plasma membrane	SLC7A8	IDA		Human	PMID:19075510
Biological Process	GO:0089718	amino acid import across plasma membrane	SLC7A8	IDA		Human	PMID:26305885
Biological Process	GO:0006865	amino acid transport	SLC7A8	IDA		Human	PMID:10391915
Biological Process	GO:0006865	amino acid transport	SLC7A8	IDA		Human	PMID:10574970
Biological Process	GO:0006865	amino acid transport	SLC7A8	IDA		Human	PMID:15918515
Biological Process	GO:0015816	glycine transport	Slc7a8	IMP		Mouse	MGI:MGI:6436375|PMID:32046769
Biological Process	GO:1904273	L-alanine import across plasma membrane	SLC7A8	IGI	UniProtKB:P08195	Human	PMID:10391915
Biological Process	GO:1902475	L-alpha-amino acid transmembrane transport	Slc7a8	IDA		Mouse	MGI:MGI:3576957|PMID:15659399
Biological Process	GO:0015807	L-amino acid transport	Slc7a8	IDA		Mouse	PMID:15659399
Biological Process	GO:1903801	L-leucine import across plasma membrane	SLC7A8	IGI	UniProtKB:P08195	Human	PMID:10391915
Biological Process	GO:1903801	L-leucine import across plasma membrane	SLC7A8	IDA		Human	PMID:19075510
Biological Process	GO:0098713	leucine import across plasma membrane	SLC7A8	IMP		Human	PMID:26050671
Biological Process	GO:0098713	leucine import across plasma membrane	SLC7A8	IDA		Human	PMID:26305885
Biological Process	GO:0015820	leucine transport	Slc7a8	IMP		Mouse	MGI:MGI:6436375|PMID:32046769
Biological Process	GO:0035524	proline transmembrane transport	Slc7a8	IMP		Mouse	MGI:MGI:6436375|PMID:32046769
Biological Process	GO:0070327	thyroid hormone transport	SLC7A8	IDA		Human	PMID:26305885
Biological Process	GO:0070327	thyroid hormone transport	Slc7a8	IMP		Mouse	MGI:MGI:4880788|PMID:21264952
Biological Process	GO:0015827	tryptophan transport	Slc7a8	IMP		Mouse	MGI:MGI:6436375|PMID:32046769
Biological Process	GO:0015829	valine transport	Slc7a8	IMP		Mouse	MGI:MGI:6436375|PMID:32046769

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern