Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Slc8a1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SLC8A1
- Mouse genes Slc8a1
- Rat genes Slc8a1
- Zfish genes slc8a1a,slc8a1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc8a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030506	ankyrin binding	SLC8A1	IPI	UniProtKB:Q01484	Human	PMID:17178715
Molecular Function	GO:0030506	ankyrin binding	Slc8a1	IPI	UniProtKB:Q8C8R3	Mouse	MGI:MGI:4844023\|PMID:20610380
Molecular Function	GO:1905060	calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	Slc8a1	IMP		Rat	PMID:17215351\|RGD:7175092
Molecular Function	GO:0005432	calcium:sodium antiporter activity	SLC8A1	IDA		Human	PMID:1374913
Molecular Function	GO:0005432	calcium:sodium antiporter activity	SLC8A1	IMP		Human	PMID:25589784
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a1	IMP		Mouse	MGI:MGI:1927695\|PMID:10967099
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a1	IDA		Rat	PMID:11342562\|RGD:7175087
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a1	IDA		Rat	PMID:11916852\|RGD:8553768
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a1	IMP		Rat	PMID:15774479\|RGD:1581354
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a1	IMP		Rat	PMID:17215351\|RGD:7175092
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a1	IDA		Rat	PMID:19481548\|RGD:8554390
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a1	IMP		Rat	PMID:20447431\|RGD:7241256
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a1	IDA		Rat	PMID:7642578\|RGD:730112
Molecular Function	GO:0005432	calcium:sodium antiporter activity	slc8a1a	IMP	ZFIN:ZDB-GENO-980202-1494	Zfish	PMID:16314583
Molecular Function	GO:0005432	calcium:sodium antiporter activity	slc8a1a	IDA		Zfish	PMID:16314583
Molecular Function	GO:0005516	calmodulin binding	SLC8A1	IDA		Human	PMID:26421717
Molecular Function	GO:0008092	cytoskeletal protein binding	SLC8A1	IDA		Human	PMID:16292983
Molecular Function	GO:0099580	monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential	Slc8a1	IMP		Rat	PMID:17215351\|RGD:7175092
Molecular Function	GO:0005515	protein binding	SLC8A1	IPI	UniProtKB:Q01484-2	Human	PMID:16292983
Molecular Function	GO:0005515	protein binding	SLC8A1	IPI	UniProtKB:Q4KMQ2	Human	PMID:25589784
Molecular Function	GO:0005515	protein binding	SLC8A1	IPI	UniProtKB:P23297	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	SLC8A1	IPI	UniProtKB:P33763	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	Slc8a1	IPI	UniProtKB:Q61066\|UniProtKB:Q80Z64	Mouse	MGI:MGI:4399017\|PMID:17093407
Molecular Function	GO:0005515	protein binding	Slc8a1	IPI	PR:Q6PIE5	Mouse	PMID:15485817
Molecular Function	GO:0005515	protein binding	Slc8a1	IPI	PR:Q8VDN2	Mouse	PMID:15485817
Molecular Function	GO:0005515	protein binding	Slc8a1	IPI	RGD:620156	Rat	PMID:14593108\|RGD:6767300
Molecular Function	GO:0005515	protein binding	Slc8a1	IPI	RGD:69306	Rat	PMID:15774479\|RGD:1581354
Molecular Function	GO:0005515	protein binding	Slc8a1	IPI	RGD:2280	Rat	PMID:15814461\|RGD:1582170
Molecular Function	GO:0005515	protein binding	Slc8a1	IPI	RGD:3377	Rat	PMID:26668322\|RGD:11526267
Molecular Function	GO:0044325	transmembrane transporter binding	Slc8a1	IPI	UniProtKB:Q61743	Mouse	MGI:MGI:4844023\|PMID:20610380
Cellular Component	GO:0030424	axon	Slc8a1	IDA		Rat	PMID:23628073\|RGD:15090846
Cellular Component	GO:0043679	axon terminus	Slc8a1	IMP		Mouse	MGI:MGI:6282180\|PMID:29274751
Cellular Component	GO:0016323	basolateral plasma membrane	Slc8a1	IDA		Mouse	PMID:11423561
Cellular Component	GO:0071944	cell periphery	SLC8A1	IDA		Human	PMID:21321244
Cellular Component	GO:0042995	cell projection	Slc8a1	IDA		Rat	PMID:16914199\|RGD:2316976
Cellular Component	GO:0030425	dendrite	Slc8a1	IDA		Rat	PMID:23628073\|RGD:15090846
Cellular Component	GO:0043198	dendritic shaft	Slc8a1	IDA		Rat	PMID:17215351\|RGD:7175092
Cellular Component	GO:0043197	dendritic spine	Slc8a1	IDA		Rat	PMID:16914199\|RGD:2316976
Cellular Component	GO:0014704	intercalated disc	Slc8a1	IDA		Rat	PMID:1514597\|RGD:8553384
Cellular Component	GO:0016020	membrane	Slc8a1	IDA		Mouse	PMID:16407245
Cellular Component	GO:0005874	microtubule	Slc8a1	IDA		Rat	PMID:16914199\|RGD:2316976
Cellular Component	GO:0005739	mitochondrion	Slc8a1	IDA		Rat	PMID:16914199\|RGD:2316976
Cellular Component	GO:0043025	neuronal cell body	Slc8a1	IDA		Rat	PMID:23628073\|RGD:15090846
Cellular Component	GO:0005654	nucleoplasm	SLC8A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SLC8A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SLC8A1	IDA		Human	PMID:1374913
Cellular Component	GO:0005886	plasma membrane	SLC8A1	IDA		Human	PMID:26421717
Cellular Component	GO:0005886	plasma membrane	Slc8a1	IDA		Mouse	PMID:21302256
Cellular Component	GO:0005886	plasma membrane	Slc8a1	IDA		Mouse	PMID:12767889
Cellular Component	GO:0005886	plasma membrane	Slc8a1	IDA		Rat	PMID:15774479\|RGD:1581354
Cellular Component	GO:0005886	plasma membrane	Slc8a1	IDA		Rat	PMID:16617138\|RGD:7175085
Cellular Component	GO:0014069	postsynaptic density	Slc8a1	IMP		Mouse	MGI:MGI:6282180\|PMID:29274751
Cellular Component	GO:0045211	postsynaptic membrane	Slc8a1	IDA		Rat	PMID:16914199\|RGD:2316976
Cellular Component	GO:0045211	postsynaptic membrane	Slc8a1	IDA		Rat	PMID:17215351\|RGD:7175092
Cellular Component	GO:0042383	sarcolemma	Slc8a1	IDA		Mouse	MGI:MGI:3610760\|PMID:16292983
Cellular Component	GO:0042383	sarcolemma	Slc8a1	IDA		Mouse	PMID:15485817
Cellular Component	GO:0042383	sarcolemma	Slc8a1	IDA		Rat	PMID:11053140\|RGD:8554533
Cellular Component	GO:0042383	sarcolemma	Slc8a1	IDA		Rat	PMID:11121386\|RGD:2316982
Cellular Component	GO:0042383	sarcolemma	Slc8a1	IDA		Rat	PMID:1514597\|RGD:8553384
Cellular Component	GO:0045202	synapse	SLC8A1	IDA		Human	PMID:21382638
Cellular Component	GO:0045202	synapse	Slc8a1	IDA		Mouse	MGI:MGI:6282180\|PMID:29274751
Cellular Component	GO:0030315	T-tubule	Slc8a1	IDA		Mouse	MGI:MGI:3610760\|PMID:16292983
Cellular Component	GO:0030315	T-tubule	Slc8a1	IDA		Mouse	PMID:22355118
Cellular Component	GO:0030315	T-tubule	Slc8a1	IDA		Mouse	PMID:15652482
Cellular Component	GO:0030315	T-tubule	Slc8a1	IDA		Rat	PMID:11121386\|RGD:2316982
Cellular Component	GO:0030315	T-tubule	Slc8a1	IDA		Rat	PMID:1514597\|RGD:8553384
Cellular Component	GO:0030018	Z disc	Slc8a1	IDA		Rat	PMID:11053140\|RGD:8554533
Cellular Component	GO:0030018	Z disc	Slc8a1	IDA		Rat	PMID:1514597\|RGD:8553384
Biological Process	GO:1901660	calcium ion export	Slc8a1	IMP		Mouse	MGI:MGI:1927695\|PMID:10967099
Biological Process	GO:1901660	calcium ion export	Slc8a1	IDA		Rat	PMID:19481548\|RGD:8554390
Biological Process	GO:0055074	calcium ion homeostasis	Slc8a1	IMP		Mouse	MGI:MGI:1927695\|PMID:10967099
Biological Process	GO:0070509	calcium ion import	SLC8A1	IDA		Human	PMID:1374913
Biological Process	GO:0070509	calcium ion import	Slc8a1	IMP		Mouse	MGI:MGI:1927695\|PMID:10967099
Biological Process	GO:0070509	calcium ion import	Slc8a1	IDA		Rat	PMID:11916852\|RGD:8553768
Biological Process	GO:0070509	calcium ion import	Slc8a1	IDA		Rat	PMID:19481548\|RGD:8554390
Biological Process	GO:0070588	calcium ion transmembrane transport	SLC8A1	IGI	UniProtKB:Q4KMQ2	Human	PMID:25589784
Biological Process	GO:0070588	calcium ion transmembrane transport	Slc8a1	IGI	UniProtKB:Q6P9J9	Mouse	MGI:MGI:5634871\|PMID:25589784
Biological Process	GO:0070588	calcium ion transmembrane transport	Slc8a1	IDA		Rat	PMID:11342562\|RGD:7175087
Biological Process	GO:0070588	calcium ion transmembrane transport	Slc8a1	IMP		Rat	PMID:17215351\|RGD:7175092
Biological Process	GO:0070588	calcium ion transmembrane transport	Slc8a1	IMP		Rat	PMID:20447431\|RGD:7241256
Biological Process	GO:0070588	calcium ion transmembrane transport	Slc8a1	IGI	UniProtKB:P48768,UniProtKB:P70549	Rat	PMID:23628073\|RGD:15090846
Biological Process	GO:0006816	calcium ion transport	Slc8a1	IDA		Mouse	PMID:10075718
Biological Process	GO:0006816	calcium ion transport	Slc8a1	IMP	MGI:MGI:3609617	Mouse	PMID:12767889
Biological Process	GO:0006816	calcium ion transport	slc8a1a	IMP	ZFIN:ZDB-GENO-980202-1494	Zfish	PMID:16314583
Biological Process	GO:0006816	calcium ion transport	slc8a1a	IDA		Zfish	PMID:16314583
Biological Process	GO:0060402	calcium ion transport into cytosol	Slc8a1	IMP		Mouse	MGI:MGI:1927695\|PMID:10967099
Biological Process	GO:0060402	calcium ion transport into cytosol	Slc8a1	IDA		Rat	PMID:9486131\|RGD:2316984
Biological Process	GO:0055013	cardiac muscle cell development	Slc8a1	IMP		Mouse	MGI:MGI:1927695\|PMID:10967099
Biological Process	GO:0055013	cardiac muscle cell development	Slc8a1	IMP	MGI:MGI:4849923	Mouse	PMID:21302256
Biological Process	GO:0060048	cardiac muscle contraction	Slc8a1	IGI	MGI:MGI:97272	Mouse	PMID:15308581
Biological Process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	Slc8a1	IDA		Rat	PMID:21779914\|RGD:8554732
Biological Process	GO:0071313	cellular response to caffeine	Slc8a1	IMP		Mouse	MGI:MGI:1927695\|PMID:10967099
Biological Process	GO:0071320	cellular response to cAMP	Slc8a1	IDA		Rat	PMID:9486131\|RGD:2316984
Biological Process	GO:0071456	cellular response to hypoxia	Slc8a1	IEP		Rat	PMID:17394575\|RGD:1642726
Biological Process	GO:0034614	cellular response to reactive oxygen species	Slc8a1	IDA		Rat	PMID:19481548\|RGD:8554390
Biological Process	GO:0035050	embryonic heart tube development	Slc8a1	IMP	MGI:MGI:4849923	Mouse	PMID:21302256
Biological Process	GO:0001892	embryonic placenta development	Slc8a1	IMP	MGI:MGI:4849923	Mouse	PMID:21302256
Biological Process	GO:0048484	enteric nervous system development	slc8a1b	IGI	ZFIN:ZDB-CRISPR-230208-16,ZFIN:ZDB-CRISPR-230208-17	Zfish	PMID:34358225
Biological Process	GO:0048484	enteric nervous system development	slc8a1a	IGI	ZFIN:ZDB-CRISPR-230208-16,ZFIN:ZDB-CRISPR-230208-17	Zfish	PMID:34358225
Biological Process	GO:0003007	heart morphogenesis	Slc8a1	IGI	MGI:MGI:97272	Mouse	PMID:15308581
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Slc8a1	IGI	UniProtKB:P48768,UniProtKB:P70549	Rat	PMID:23628073\|RGD:15090846
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Slc8a1	IMP		Rat	PMID:12234816\|RGD:1581355
Biological Process	GO:0006874	intracellular calcium ion homeostasis	slc8a1a	IMP	ZFIN:ZDB-GENO-980202-211	Zfish	PMID:16314582
Biological Process	GO:0006883	intracellular sodium ion homeostasis	SLC8A1	IDA		Human	PMID:1374913
Biological Process	GO:0055001	muscle cell development	Slc8a1	IGI	MGI:MGI:97272	Mouse	PMID:15308581
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	Slc8a1	IMP		Mouse	MGI:MGI:1927695\|PMID:10967099
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	Slc8a1	IMP		Mouse	MGI:MGI:6282180\|PMID:29274751
Biological Process	GO:0030501	positive regulation of bone mineralization	SLC8A1	IMP		Human	PMID:25589784
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Slc8a1	IMP		Rat	PMID:16679322\|RGD:1581353
Biological Process	GO:0010763	positive regulation of fibroblast migration	Slc8a1	IMP		Rat	PMID:19770194\|RGD:6771237
Biological Process	GO:0098735	positive regulation of the force of heart contraction	SLC8A1	IMP		Human	PMID:15105296
Biological Process	GO:0009791	post-embryonic development	Slc8a1	IGI	MGI:MGI:97272	Mouse	PMID:15308581
Biological Process	GO:0051924	regulation of calcium ion transport	Slc8a1	IMP		Rat	PMID:15774479\|RGD:1581354
Biological Process	GO:0051924	regulation of calcium ion transport	Slc8a1	IMP		Rat	PMID:16679322\|RGD:1581353
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	Slc8a1	IDA		Rat	PMID:21779914\|RGD:8554732
Biological Process	GO:0010468	regulation of gene expression	Slc8a1	IMP		Mouse	MGI:MGI:6282180\|PMID:29274751
Biological Process	GO:0008016	regulation of heart contraction	slc8a1a	IMP	ZFIN:ZDB-GENO-070808-5	Zfish	PMID:9007249
Biological Process	GO:0008016	regulation of heart contraction	slc8a1a	IMP	ZFIN:ZDB-GENO-980202-1494	Zfish	PMID:25588501
Biological Process	GO:0008016	regulation of heart contraction	slc8a1a	IMP	ZFIN:ZDB-GENO-070808-8	Zfish	PMID:9007249
Biological Process	GO:0008016	regulation of heart contraction	slc8a1a	IMP	ZFIN:ZDB-MRPHLNO-051228-4	Zfish	PMID:16314582
Biological Process	GO:0008016	regulation of heart contraction	slc8a1a	IMP	ZFIN:ZDB-GENO-070808-4	Zfish	PMID:9007249
Biological Process	GO:0008016	regulation of heart contraction	slc8a1a	IMP	ZFIN:ZDB-GENO-980202-1494	Zfish	PMID:16314583
Biological Process	GO:0008016	regulation of heart contraction	slc8a1a	IGI	ZFIN:ZDB-GENO-980202-1494,ZFIN:ZDB-MRPHLNO-150423-3	Zfish	PMID:25588501
Biological Process	GO:0008016	regulation of heart contraction	slc8a1a	IMP	ZFIN:ZDB-GENO-980202-1082	Zfish	PMID:9007249
Biological Process	GO:0008016	regulation of heart contraction	slc8a1a	IGI	ZFIN:ZDB-GENO-980202-1494,ZFIN:ZDB-MRPHLNO-150506-1	Zfish	PMID:25588501
Biological Process	GO:0008016	regulation of heart contraction	slc8a1a	IMP	ZFIN:ZDB-GENO-070808-10	Zfish	PMID:9007249
Biological Process	GO:0008016	regulation of heart contraction	slc8a1a	IMP	ZFIN:ZDB-GENO-980202-211	Zfish	PMID:16314582
Biological Process	GO:0008016	regulation of heart contraction	slc8a1a	IMP	ZFIN:ZDB-GENO-980202-1494	Zfish	PMID:9007249
Biological Process	GO:0008016	regulation of heart contraction	slc8a1a	IMP	ZFIN:ZDB-MRPHLNO-060110-1	Zfish	PMID:16314583
Biological Process	GO:0008016	regulation of heart contraction	slc8a1a	IMP	ZFIN:ZDB-GENO-070808-6	Zfish	PMID:9007249
Biological Process	GO:0002027	regulation of heart rate	Slc8a1	IMP		Mouse	MGI:MGI:1927695\|PMID:10967099
Biological Process	GO:0002028	regulation of sodium ion transport	Slc8a1	IMP		Rat	PMID:15774479\|RGD:1581354
Biological Process	GO:0002026	regulation of the force of heart contraction	Slc8a1	IMP	MGI:MGI:3609617	Mouse	PMID:12767889
Biological Process	GO:0044557	relaxation of smooth muscle	Slc8a1	IMP		Mouse	MGI:MGI:1927695\|PMID:10967099
Biological Process	GO:0033198	response to ATP	Slc8a1	IDA		Rat	PMID:17466270\|RGD:1642721
Biological Process	GO:0009749	response to glucose	Slc8a1	IEP		Rat	PMID:17446486\|RGD:1642722
Biological Process	GO:0042542	response to hydrogen peroxide	Slc8a1	IEP		Rat	PMID:17446483\|RGD:1642724
Biological Process	GO:0001666	response to hypoxia	Slc8a1	IDA		Rat	PMID:17267548\|RGD:1642729
Biological Process	GO:0035902	response to immobilization stress	Slc8a1	IEP		Rat	PMID:17394575\|RGD:1642726
Biological Process	GO:0035994	response to muscle stretch	SLC8A1	IMP		Human	PMID:15105296
Biological Process	GO:0007584	response to nutrient	Slc8a1	IEP		Rat	PMID:17612656\|RGD:1642718
Biological Process	GO:0009410	response to xenobiotic stimulus	Slc8a1	IEP		Rat	PMID:16343576\|RGD:1598724
Biological Process	GO:0045214	sarcomere organization	slc8a1a	IMP	ZFIN:ZDB-GENO-980202-1494	Zfish	PMID:28826496
Biological Process	GO:0045214	sarcomere organization	slc8a1a	IMP	ZFIN:ZDB-GENO-980202-211	Zfish	PMID:16314582
Biological Process	GO:0036376	sodium ion export across plasma membrane	Slc8a1	IMP		Mouse	MGI:MGI:1927695\|PMID:10967099
Biological Process	GO:0036376	sodium ion export across plasma membrane	Slc8a1	IDA		Rat	PMID:11916852\|RGD:8553768
Biological Process	GO:0036376	sodium ion export across plasma membrane	Slc8a1	IDA		Rat	PMID:19481548\|RGD:8554390
Biological Process	GO:0098719	sodium ion import across plasma membrane	SLC8A1	IDA		Human	PMID:1374913
Biological Process	GO:0098719	sodium ion import across plasma membrane	Slc8a1	IMP		Mouse	MGI:MGI:1927695\|PMID:10967099
Biological Process	GO:0098719	sodium ion import across plasma membrane	Slc8a1	IDA		Rat	PMID:11916852\|RGD:8553768
Biological Process	GO:0035725	sodium ion transmembrane transport	SLC8A1	IGI	UniProtKB:Q4KMQ2	Human	PMID:25589784
Biological Process	GO:0035725	sodium ion transmembrane transport	SLC8A1	IMP		Human	PMID:25589784
Biological Process	GO:0006814	sodium ion transport	Slc8a1	IDA		Mouse	PMID:10075718
Biological Process	GO:0006814	sodium ion transport	Slc8a1	IDA		Rat	PMID:9486131\|RGD:2316984
Biological Process	GO:0021537	telencephalon development	Slc8a1	IEP		Rat	PMID:12502534\|RGD:2316981
Biological Process	GO:0014829	vascular associated smooth muscle contraction	Slc8a1	IMP		Mouse	MGI:MGI:1927695\|PMID:10967099

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.