Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC8A2
  • Mouse genes Slc8a2
  • Rat genes Slc8a2
  • Zfish genes slc8a2a,slc8a2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc8a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015085	calcium ion transmembrane transporter activity	Slc8a2	IMP		Mouse	MGI:MGI:3796351|PMID:17884163
Molecular Function	GO:1905060	calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	Slc8a2	IDA		Rat	PMID:8021246|RGD:730182
Molecular Function	GO:1905060	calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	Slc8a2	IMP		Rat	PMID:8021246|RGD:730182
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a2	IMP		Mouse	MGI:MGI:2664655|PMID:12818181
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a2	IDA		Rat	PMID:17343909|RGD:7241257
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a2	IDA		Rat	PMID:9486131|RGD:2316984
Molecular Function	GO:0005515	protein binding	Slc8a2	IPI	RGD:62000	Rat	PMID:16679322|RGD:1581353
Molecular Function	GO:0015081	sodium ion transmembrane transporter activity	Slc8a2	IDA		Rat	PMID:8021246|RGD:730182
Cellular Component	GO:0030424	axon	Slc8a2	IDA		Rat	PMID:21118538|RGD:15090835
Cellular Component	GO:0030424	axon	Slc8a2	IDA		Rat	PMID:23628073|RGD:15090846
Cellular Component	GO:0043679	axon terminus	Slc8a2	IMP		Mouse	MGI:MGI:6282180|PMID:29274751
Cellular Component	GO:0042995	cell projection	Slc8a2	IDA		Rat	PMID:16914199|RGD:2316976
Cellular Component	GO:0030425	dendrite	Slc8a2	IDA		Rat	PMID:23628073|RGD:15090846
Cellular Component	GO:0043197	dendritic spine	Slc8a2	IDA		Rat	PMID:16914199|RGD:2316976
Cellular Component	GO:0005874	microtubule	Slc8a2	IDA		Rat	PMID:16914199|RGD:2316976
Cellular Component	GO:0005739	mitochondrion	Slc8a2	IDA		Rat	PMID:16914199|RGD:2316976
Cellular Component	GO:0043025	neuronal cell body	Slc8a2	IDA		Rat	PMID:16914199|RGD:2316976
Cellular Component	GO:0043025	neuronal cell body	Slc8a2	IDA		Rat	PMID:21118538|RGD:15090835
Cellular Component	GO:0043025	neuronal cell body	Slc8a2	IDA		Rat	PMID:23628073|RGD:15090846
Cellular Component	GO:0005886	plasma membrane	Slc8a2	IMP		Mouse	MGI:MGI:2664655|PMID:12818181
Cellular Component	GO:0005886	plasma membrane	Slc8a2	IDA		Rat	PMID:16914199|RGD:2316976
Cellular Component	GO:0005886	plasma membrane	Slc8a2	IDA		Rat	PMID:17343909|RGD:7241257
Cellular Component	GO:0014069	postsynaptic density	Slc8a2	IMP		Mouse	MGI:MGI:6282180|PMID:29274751
Cellular Component	GO:0045211	postsynaptic membrane	Slc8a2	IDA		Rat	PMID:16914199|RGD:2316976
Cellular Component	GO:0098793	presynapse	SLC8A2	IDA		Human	PMID:21382638
Cellular Component	GO:0045202	synapse	Slc8a2	IDA		Mouse	MGI:MGI:6282180|PMID:29274751
Biological Process	GO:1990034	calcium ion export across plasma membrane	Slc8a2	IMP		Mouse	MGI:MGI:3796351|PMID:17884163
Biological Process	GO:1990034	calcium ion export across plasma membrane	Slc8a2	IDA		Rat	PMID:17343909|RGD:7241257
Biological Process	GO:0098703	calcium ion import across plasma membrane	Slc8a2	IDA		Rat	PMID:17343909|RGD:7241257
Biological Process	GO:0070588	calcium ion transmembrane transport	Slc8a2	IMP		Mouse	MGI:MGI:2664655|PMID:12818181
Biological Process	GO:0070588	calcium ion transmembrane transport	Slc8a2	IGI	UniProtKB:P70549,UniProtKB:Q01728	Rat	PMID:23628073|RGD:15090846
Biological Process	GO:0070588	calcium ion transmembrane transport	Slc8a2	IDA		Rat	PMID:8021246|RGD:730182
Biological Process	GO:0060402	calcium ion transport into cytosol	Slc8a2	IDA		Rat	PMID:9486131|RGD:2316984
Biological Process	GO:0050890	cognition	Slc8a2	IMP		Mouse	MGI:MGI:6384051|PMID:27595821
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Slc8a2	IMP		Mouse	MGI:MGI:2664655|PMID:12818181
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Slc8a2	IMP		Mouse	MGI:MGI:6282180|PMID:29274751
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Slc8a2	IDA		Rat	PMID:22561287|RGD:15090849
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Slc8a2	IGI	UniProtKB:P70549,UniProtKB:Q01728	Rat	PMID:23628073|RGD:15090846
Biological Process	GO:0007612	learning	Slc8a2	IMP		Mouse	MGI:MGI:2664655|PMID:12818181
Biological Process	GO:0007611	learning or memory	Slc8a2	IMP		Mouse	MGI:MGI:6282180|PMID:29274751
Biological Process	GO:0060291	long-term synaptic potentiation	Slc8a2	IMP		Mouse	MGI:MGI:2664655|PMID:12818181
Biological Process	GO:0060291	long-term synaptic potentiation	Slc8a2	IMP		Mouse	MGI:MGI:6282180|PMID:29274751
Biological Process	GO:0007613	memory	Slc8a2	IMP		Mouse	MGI:MGI:2664655|PMID:12818181
Biological Process	GO:0098815	modulation of excitatory postsynaptic potential	Slc8a2	IMP		Mouse	MGI:MGI:6282180|PMID:29274751
Biological Process	GO:0070050	neuron cellular homeostasis	Slc8a2	IMP		Mouse	MGI:MGI:3796351|PMID:17884163
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	Slc8a2	IMP		Mouse	MGI:MGI:6282180|PMID:29274751
Biological Process	GO:0099608	regulation of action potential firing pattern	Slc8a2	IMP		Mouse	MGI:MGI:3796351|PMID:17884163
Biological Process	GO:0106056	regulation of calcineurin-mediated signaling	Slc8a2	IMP		Mouse	MGI:MGI:6282180|PMID:29274751
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	Slc8a2	IMP		Mouse	MGI:MGI:3796351|PMID:17884163
Biological Process	GO:0010468	regulation of gene expression	Slc8a2	IMP		Mouse	MGI:MGI:6282180|PMID:29274751
Biological Process	GO:0048172	regulation of short-term neuronal synaptic plasticity	Slc8a2	IMP		Mouse	MGI:MGI:2664655|PMID:12818181
Biological Process	GO:0002931	response to ischemia	Slc8a2	IMP		Mouse	MGI:MGI:3796351|PMID:17884163
Biological Process	GO:0033280	response to vitamin D	Slc8a2	IEP		Rat	PMID:20113508|RGD:2316972
Biological Process	GO:0035725	sodium ion transmembrane transport	Slc8a2	IMP		Mouse	MGI:MGI:2664655|PMID:12818181
Biological Process	GO:0035725	sodium ion transmembrane transport	Slc8a2	IDA		Rat	PMID:8021246|RGD:730182
Biological Process	GO:0006814	sodium ion transport	Slc8a2	IDA		Rat	PMID:9486131|RGD:2316984
Biological Process	GO:0050808	synapse organization	Slc8a2	IMP		Mouse	MGI:MGI:6282180|PMID:29274751
Biological Process	GO:0021537	telencephalon development	Slc8a2	IEP		Rat	PMID:12502534|RGD:2316981

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern