Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Slc8a3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SLC8A3
- Mouse genes Slc8a3
- Rat genes Slc8a3
- Zfish genes slc8a3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc8a3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015368	calcium:monoatomic cation antiporter activity	Slc8a3	IDA		Mouse	PMID:8798769
Molecular Function	GO:1905060	calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	Slc8a3	IDA		Rat	PMID:8798769\|RGD:730187
Molecular Function	GO:1905060	calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	Slc8a3	IMP		Rat	PMID:8798769\|RGD:730187
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a3	IMP		Mouse	MGI:MGI:5013898\|PMID:21593315
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a3	IMP		Mouse	MGI:MGI:3027331\|PMID:14722618
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a3	IDA		Rat	PMID:17343909\|RGD:7241257
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a3	EXP		Rat	PMID:24101730\|RGD:12903236
Molecular Function	GO:0005432	calcium:sodium antiporter activity	Slc8a3	IDA		Rat	PMID:8798769\|RGD:730187
Molecular Function	GO:0099580	monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential	Slc8a3	IMP		Mouse	MGI:MGI:5013898\|PMID:21593315
Cellular Component	GO:0030424	axon	Slc8a3	IDA		Rat	PMID:23628073\|RGD:15090846
Cellular Component	GO:0043679	axon terminus	Slc8a3	IMP		Mouse	MGI:MGI:6282180\|PMID:29274751
Cellular Component	GO:0042995	cell projection	Slc8a3	IDA		Rat	PMID:16914199\|RGD:2316976
Cellular Component	GO:0030425	dendrite	Slc8a3	IDA		Rat	PMID:23628073\|RGD:15090846
Cellular Component	GO:0043197	dendritic spine	Slc8a3	IDA		Rat	PMID:16914199\|RGD:2316976
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Slc8a3	IDA		Mouse	MGI:MGI:5693358\|PMID:24101730
Cellular Component	GO:0005874	microtubule	Slc8a3	IDA		Rat	PMID:16914199\|RGD:2316976
Cellular Component	GO:0005741	mitochondrial outer membrane	Slc8a3	IDA		Mouse	MGI:MGI:5693358\|PMID:24101730
Cellular Component	GO:0005739	mitochondrion	Slc8a3	IDA		Rat	PMID:16914199\|RGD:2316976
Cellular Component	GO:0031594	neuromuscular junction	Slc8a3	IDA		Mouse	MGI:MGI:3027331\|PMID:14722618
Cellular Component	GO:0043025	neuronal cell body	Slc8a3	IDA		Rat	PMID:16914199\|RGD:2316976
Cellular Component	GO:0043025	neuronal cell body	Slc8a3	IDA		Rat	PMID:23628073\|RGD:15090846
Cellular Component	GO:0048471	perinuclear region of cytoplasm	SLC8A3	IDA		Human	PMID:21959935
Cellular Component	GO:0005886	plasma membrane	SLC8A3	IDA		Human	PMID:21959935
Cellular Component	GO:0005886	plasma membrane	Slc8a3	IDA		Mouse	MGI:MGI:5693358\|PMID:24101730
Cellular Component	GO:0005886	plasma membrane	Slc8a3	IDA		Rat	PMID:16914199\|RGD:2316976
Cellular Component	GO:0005886	plasma membrane	Slc8a3	IDA		Rat	PMID:17343909\|RGD:7241257
Cellular Component	GO:0014069	postsynaptic density	Slc8a3	IMP		Mouse	MGI:MGI:6282180\|PMID:29274751
Cellular Component	GO:0045211	postsynaptic membrane	Slc8a3	IDA		Rat	PMID:16914199\|RGD:2316976
Cellular Component	GO:0042383	sarcolemma	Slc8a3	IDA		Mouse	MGI:MGI:3027331\|PMID:14722618
Cellular Component	GO:0042383	sarcolemma	Slc8a3	IDA		Rat	PMID:11121386\|RGD:2316982
Cellular Component	GO:0045202	synapse	SLC8A3	IDA		Human	PMID:21382638
Cellular Component	GO:0045202	synapse	Slc8a3	IDA		Mouse	MGI:MGI:6282180\|PMID:29274751
Biological Process	GO:1990034	calcium ion export across plasma membrane	Slc8a3	IDA		Rat	PMID:17343909\|RGD:7241257
Biological Process	GO:0098703	calcium ion import across plasma membrane	Slc8a3	IDA		Rat	PMID:17343909\|RGD:7241257
Biological Process	GO:0070588	calcium ion transmembrane transport	Slc8a3	IMP		Mouse	MGI:MGI:3027331\|PMID:14722618
Biological Process	GO:0070588	calcium ion transmembrane transport	Slc8a3	IDA		Mouse	MGI:MGI:83241\|PMID:8798769
Biological Process	GO:0070588	calcium ion transmembrane transport	Slc8a3	IMP		Mouse	MGI:MGI:5013898\|PMID:21593315
Biological Process	GO:0070588	calcium ion transmembrane transport	Slc8a3	IGI	UniProtKB:P48768,UniProtKB:Q01728	Rat	PMID:23628073\|RGD:15090846
Biological Process	GO:0060402	calcium ion transport into cytosol	Slc8a3	IDA		Rat	PMID:9486131\|RGD:2316984
Biological Process	GO:0071320	cellular response to cAMP	Slc8a3	IDA		Rat	PMID:9486131\|RGD:2316984
Biological Process	GO:0071456	cellular response to hypoxia	Slc8a3	IDA		Mouse	MGI:MGI:5693358\|PMID:24101730
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Slc8a3	IMP		Mouse	PMID:24029230
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Slc8a3	IMP		Mouse	MGI:MGI:6282180\|PMID:29274751
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Slc8a3	IMP		Mouse	MGI:MGI:5013898\|PMID:21593315
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Slc8a3	IMP		Mouse	MGI:MGI:3027331\|PMID:14722618
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Slc8a3	IDA		Rat	PMID:22561287\|RGD:15090849
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Slc8a3	IGI	UniProtKB:P48768,UniProtKB:Q01728	Rat	PMID:23628073\|RGD:15090846
Biological Process	GO:0007612	learning	Slc8a3	IMP		Mouse	MGI:MGI:5013898\|PMID:21593315
Biological Process	GO:0007611	learning or memory	Slc8a3	IMP		Mouse	MGI:MGI:6282180\|PMID:29274751
Biological Process	GO:0060291	long-term synaptic potentiation	Slc8a3	IMP		Mouse	MGI:MGI:5013898\|PMID:21593315
Biological Process	GO:0060291	long-term synaptic potentiation	Slc8a3	IMP		Mouse	MGI:MGI:6282180\|PMID:29274751
Biological Process	GO:0007613	memory	Slc8a3	IMP		Mouse	MGI:MGI:5013898\|PMID:21593315
Biological Process	GO:0030001	metal ion transport	Slc8a3	IDA		Mouse	PMID:8798769
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	Slc8a3	IMP		Mouse	MGI:MGI:5693358\|PMID:24101730
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	Slc8a3	IMP		Mouse	MGI:MGI:5693358\|PMID:24101730
Biological Process	GO:0098815	modulation of excitatory postsynaptic potential	Slc8a3	IMP		Mouse	MGI:MGI:6282180\|PMID:29274751
Biological Process	GO:0042552	myelination	Slc8a3	IMP		Mouse	MGI:MGI:5524192\|PMID:21959935
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	Slc8a3	IMP		Mouse	MGI:MGI:6282180\|PMID:29274751
Biological Process	GO:0048709	oligodendrocyte differentiation	Slc8a3	IMP		Mouse	MGI:MGI:5524192\|PMID:21959935
Biological Process	GO:0014819	regulation of skeletal muscle contraction	Slc8a3	IMP		Mouse	MGI:MGI:3027331\|PMID:14722618
Biological Process	GO:0035725	sodium ion transmembrane transport	Slc8a3	IMP		Mouse	MGI:MGI:3027331\|PMID:14722618
Biological Process	GO:0006814	sodium ion transport	Slc8a3	IDA		Rat	PMID:9486131\|RGD:2316984
Biological Process	GO:0050808	synapse organization	Slc8a3	IMP		Mouse	MGI:MGI:6282180\|PMID:29274751
Biological Process	GO:0021537	telencephalon development	Slc8a3	IEP		Rat	PMID:11036162\|RGD:2316983

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.