Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC9A1
  • Mouse genes Slc9a1
  • Rat genes Slc9a1
  • Zfish genes slc9a1a,slc9a1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc9a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048306	calcium-dependent protein binding	SLC9A1	IDA		Human	PMID:15035633
Molecular Function	GO:0043167	ion binding	SLC9A1	EXP		Human	PMID:34439840
Molecular Function	GO:0005515	protein binding	SLC9A1	IPI	UniProtKB:Q99653	Human	PMID:11350981
Molecular Function	GO:0005515	protein binding	SLC9A1	IPI	UniProtKB:Q96BS2	Human	PMID:11696366
Molecular Function	GO:0005515	protein binding	SLC9A1	IPI	UniProtKB:Q96BS2	Human	PMID:12809501
Molecular Function	GO:0005515	protein binding	SLC9A1	IPI	UniProtKB:Q99653	Human	PMID:15035633
Molecular Function	GO:0005515	protein binding	SLC9A1	IPI	UniProtKB:O43745	Human	PMID:16710297
Molecular Function	GO:0005515	protein binding	SLC9A1	IPI	UniProtKB:O43745	Human	PMID:21392185
Molecular Function	GO:0005515	protein binding	SLC9A1	IPI	UniProtKB:P0DP23	Human	PMID:30287853
Molecular Function	GO:0005515	protein binding	SLC9A1	IPI	UniProtKB:Q96BS2	Human	PMID:30287853
Molecular Function	GO:0005515	protein binding	SLC9A1	IPI	UniProtKB:O43745	Human	PMID:31912575
Molecular Function	GO:0005515	protein binding	SLC9A1	IPI	UniProtKB:Q96BS2	Human	PMID:31912575
Molecular Function	GO:0005515	protein binding	SLC9A1	IPI	UniProtKB:Q99653	Human	PMID:31912575
Molecular Function	GO:0005515	protein binding	SLC9A1	IPI	UniProtKB:Q99653	Human	PMID:8901634
Molecular Function	GO:0005515	protein binding	Slc9a1	IPI	UniProtKB:Q810D1	Rat	PMID:12576672|RGD:1299552
Molecular Function	GO:0005515	protein binding	Slc9a1	IPI	UniProtKB:Q96BS2	Rat	PMID:18321853|RGD:8554433
Molecular Function	GO:0030346	protein phosphatase 2B binding	SLC9A1	IDA		Human	PMID:22688515
Molecular Function	GO:0030346	protein phosphatase 2B binding	SLC9A1	IPI	UniProtKB:P16298	Human	PMID:22688515
Molecular Function	GO:0030346	protein phosphatase 2B binding	SLC9A1	IPI	UniProtKB:Q08209	Human	PMID:22688515
Molecular Function	GO:0015385	sodium:proton antiporter activity	SLC9A1	IDA		Human	PMID:11350981
Molecular Function	GO:0015385	sodium:proton antiporter activity	SLC9A1	IDA		Human	PMID:24840010
Molecular Function	GO:0015385	sodium:proton antiporter activity	SLC9A1	IDA		Human	PMID:8901634
Molecular Function	GO:0015385	sodium:proton antiporter activity	Slc9a1	IMP		Mouse	PMID:23677982
Molecular Function	GO:0015385	sodium:proton antiporter activity	Slc9a1	IDA		Mouse	PMID:10666043
Molecular Function	GO:0015385	sodium:proton antiporter activity	Slc9a1	IMP		Rat	PMID:16002403|RGD:1581387
Molecular Function	GO:0015385	sodium:proton antiporter activity	Slc9a1	IDA		Rat	PMID:18321853|RGD:8554433
Cellular Component	GO:0016324	apical plasma membrane	Slc9a1	IDA		Mouse	PMID:21705333
Cellular Component	GO:0016324	apical plasma membrane	Slc9a1	IDA		Rat	PMID:23869188|RGD:155226878
Cellular Component	GO:0016323	basolateral plasma membrane	Slc9a1	IDA		Rat	PMID:9438178|RGD:1625558
Cellular Component	GO:0090533	cation-transporting ATPase complex	SLC9A1	IDA		Human	PMID:24840010
Cellular Component	GO:0009986	cell surface	Slc9a1	IDA		Rat	PMID:20868366|RGD:7349316
Cellular Component	GO:0005737	cytoplasm	SLC9A1	IDA		Human	PMID:21553168
Cellular Component	GO:0005783	endoplasmic reticulum	Slc9a1	IDA		Rat	PMID:21543739|RGD:8554239
Cellular Component	GO:0070062	extracellular exosome	SLC9A1	HDA		Human	PMID:19199708
Cellular Component	GO:0005925	focal adhesion	SLC9A1	HDA		Human	PMID:21423176
Cellular Component	GO:0014704	intercalated disc	Slc9a1	IDA		Rat	PMID:20868366|RGD:7349316
Cellular Component	GO:0016020	membrane	Slc9a1	IDA		Mouse	PMID:12619893
Cellular Component	GO:0045121	membrane raft	SLC9A1	IDA		Human	PMID:22688515
Cellular Component	GO:0045121	membrane raft	Slc9a1	IDA		Rat	PMID:16002403|RGD:1581387
Cellular Component	GO:0005739	mitochondrion	Slc9a1	IDA		Rat	PMID:21297023|RGD:6771330
Cellular Component	GO:0005654	nucleoplasm	SLC9A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Slc9a1	IDA		Rat	PMID:20868366|RGD:7349316
Cellular Component	GO:0005886	plasma membrane	SLC9A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SLC9A1	IDA		Human	PMID:15035633
Cellular Component	GO:0005886	plasma membrane	SLC9A1	IDA		Human	PMID:21553168
Cellular Component	GO:0005886	plasma membrane	SLC9A1	IDA		Human	PMID:24840010
Cellular Component	GO:0005886	plasma membrane	Slc9a1	IDA		Rat	PMID:18321853|RGD:8554433
Cellular Component	GO:0005886	plasma membrane	Slc9a1	IDA		Rat	PMID:20868366|RGD:7349316
Cellular Component	GO:0005886	plasma membrane	Slc9a1	IDA		Rat	PMID:21543739|RGD:8554239
Cellular Component	GO:0042383	sarcolemma	Slc9a1	IDA		Rat	PMID:20868366|RGD:7349316
Cellular Component	GO:0030315	T-tubule	Slc9a1	IDA		Rat	PMID:20868366|RGD:7349316
Cellular Component	GO:1990351	transporter complex	Slc9a1	IDA		Mouse	PMID:23904602
Biological Process	GO:0086003	cardiac muscle cell contraction	Slc9a1	IEP		Rat	PMID:20868366|RGD:7349316
Biological Process	GO:0055007	cardiac muscle cell differentiation	Slc9a1	IMP		Mouse	PMID:19011045
Biological Process	GO:0030154	cell differentiation	Slc9a1	IEP		Rat	PMID:16495213|RGD:1625562
Biological Process	GO:0071468	cellular response to acidic pH	SLC9A1	IDA		Human	PMID:24840010
Biological Process	GO:0071236	cellular response to antibiotic	Slc9a1	IEP		Rat	PMID:20868366|RGD:7349316
Biological Process	GO:0070417	cellular response to cold	Slc9a1	IEP		Rat	PMID:15452191|RGD:1625557
Biological Process	GO:0071257	cellular response to electrical stimulus	Slc9a1	IEP		Rat	PMID:20868366|RGD:7349316
Biological Process	GO:0071872	cellular response to epinephrine stimulus	SLC9A1	IMP		Human	PMID:21359875
Biological Process	GO:0071456	cellular response to hypoxia	Slc9a1	IDA		Rat	PMID:20868366|RGD:7349316
Biological Process	GO:0032869	cellular response to insulin stimulus	Slc9a1	IDA		Rat	PMID:20868366|RGD:7349316
Biological Process	GO:0071407	cellular response to organic cyclic compound	Slc9a1	IEP		Rat	PMID:20868366|RGD:7349316
Biological Process	GO:0009790	embryo development	Slc9a1	IMP		Mouse	PMID:23677982
Biological Process	GO:0006883	intracellular sodium ion homeostasis	SLC9A1	IDA		Human	PMID:24840010
Biological Process	GO:0043066	negative regulation of apoptotic process	Slc9a1	IMP		Rat	PMID:17552965|RGD:1625559
Biological Process	GO:0045760	positive regulation of action potential	Slc9a1	IMP		Rat	PMID:18319243|RGD:6771338
Biological Process	GO:0043065	positive regulation of apoptotic process	Slc9a1	IMP		Rat	PMID:22407349|RGD:8693684
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	SLC9A1	IDA		Human	PMID:22688515
Biological Process	GO:1903281	positive regulation of calcium:sodium antiporter activity	SLC9A1	IMP		Human	PMID:15105296
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	SLC9A1	IMP		Human	PMID:21359875
Biological Process	GO:0030307	positive regulation of cell growth	Slc9a1	IMP		Rat	PMID:19687166|RGD:6771333
Biological Process	GO:1902533	positive regulation of intracellular signal transduction	Slc9a1	IMP		Rat	PMID:14600156|RGD:1581388
Biological Process	GO:0035794	positive regulation of mitochondrial membrane permeability	Slc9a1	IMP		Rat	PMID:21297023|RGD:6771330
Biological Process	GO:0098735	positive regulation of the force of heart contraction	SLC9A1	IMP		Human	PMID:15105296
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SLC9A1	IDA		Human	PMID:22688515
Biological Process	GO:1902600	proton transmembrane transport	SLC9A1	IDA		Human	PMID:24840010
Biological Process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	SLC9A1	IMP		Human	PMID:15105296
Biological Process	GO:0051453	regulation of intracellular pH	SLC9A1	IDA		Human	PMID:15035633
Biological Process	GO:0051453	regulation of intracellular pH	SLC9A1	IDA		Human	PMID:24840010
Biological Process	GO:0051453	regulation of intracellular pH	Slc9a1	IMP		Rat	PMID:22387884|RGD:6771326
Biological Process	GO:0006885	regulation of pH	SLC9A1	IDA		Human	PMID:8901634
Biological Process	GO:0006885	regulation of pH	Slc9a1	IMP	MGI:MGI:2429323	Mouse	PMID:10673550
Biological Process	GO:0006885	regulation of pH	Slc9a1	IDA		Mouse	PMID:10666043
Biological Process	GO:0051930	regulation of sensory perception of pain	Slc9a1	IMP		Rat	PMID:21763398|RGD:6771328
Biological Process	GO:0002026	regulation of the force of heart contraction	Slc9a1	IMP		Rat	PMID:21659487|RGD:6771329
Biological Process	GO:0086092	regulation of the force of heart contraction by cardiac conduction	SLC9A1	IMP		Human	PMID:21359875
Biological Process	GO:0010447	response to acidic pH	SLC9A1	IDA		Human	PMID:8901634
Biological Process	GO:0010447	response to acidic pH	Slc9a1	IMP	MGI:MGI:2429323	Mouse	PMID:10673550
Biological Process	GO:0010447	response to acidic pH	Slc9a1	IDA		Rat	PMID:18321853|RGD:8554433
Biological Process	GO:0035994	response to muscle stretch	SLC9A1	IMP		Human	PMID:15105296
Biological Process	GO:0014070	response to organic cyclic compound	Slc9a1	IDA		Rat	PMID:17308111|RGD:1625561
Biological Process	GO:0098719	sodium ion import across plasma membrane	SLC9A1	IDA		Human	PMID:24840010
Biological Process	GO:0006814	sodium ion transport	Slc9a1	IDA		Mouse	PMID:10666043
Biological Process	GO:0048863	stem cell differentiation	Slc9a1	IMP		Mouse	PMID:19011045

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern