Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLC9A3
  • Mouse genes Slc9a3
  • Rat genes Slc9a3
  • Zfish genes slc9a3.1,slc9a3.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slc9a3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	SLC9A3	IDA		Human	PMID:35613257
Molecular Function	GO:0030165	PDZ domain binding	Slc9a3	IDA		Mouse	MGI:MGI:3603991|PMID:16141316
Molecular Function	GO:0035091	phosphatidylinositol binding	SLC9A3	IDA		Human	PMID:35613257
Molecular Function	GO:0005515	protein binding	SLC9A3	IPI	UniProtKB:Q6P0Q8	Human	PMID:16159897
Molecular Function	GO:0005515	protein binding	SLC9A3	IPI	UniProtKB:Q86UT5	Human	PMID:19088451
Molecular Function	GO:0005515	protein binding	Slc9a3	IPI	UniProtKB:Q810D1	Rat	PMID:12576672|RGD:1299552
Molecular Function	GO:0005515	protein binding	Slc9a3	IPI	UniProtKB:Q9QX74	Rat	PMID:16293618|RGD:8553686
Molecular Function	GO:0005515	protein binding	Slc9a3	IPI	RGD:628837	Rat	PMID:24657527|RGD:9587756
Molecular Function	GO:0015385	sodium:proton antiporter activity	SLC9A3	IDA		Human	PMID:26358773
Molecular Function	GO:0015385	sodium:proton antiporter activity	Slc9a3	IDA		Mouse	PMID:10666043
Molecular Function	GO:0015385	sodium:proton antiporter activity	Slc9a3	IDA		Rat	PMID:11880335|RGD:737665
Molecular Function	GO:0015385	sodium:proton antiporter activity	Slc9a3	IDA		Rat	PMID:12907430|RGD:1581380
Molecular Function	GO:0015385	sodium:proton antiporter activity	Slc9a3	IDA		Rat	PMID:15265811|RGD:1625070
Molecular Function	GO:0015385	sodium:proton antiporter activity	slc9a3.2	IDA		Zfish	PMID:24401990
Cellular Component	GO:0016324	apical plasma membrane	Slc9a3	IDA		Mouse	PMID:12169661
Cellular Component	GO:0016324	apical plasma membrane	Slc9a3	IDA		Rat	PMID:12907430|RGD:1581380
Cellular Component	GO:0016324	apical plasma membrane	Slc9a3	IDA		Rat	PMID:20584908|RGD:10047312
Cellular Component	GO:0016324	apical plasma membrane	slc9a3.2	IDA		Zfish	PMID:23565095
Cellular Component	GO:0005903	brush border	Slc9a3	IDA		Rat	PMID:11880335|RGD:737665
Cellular Component	GO:0031526	brush border membrane	Slc9a3	IDA		Mouse	MGI:MGI:3603991|PMID:16141316
Cellular Component	GO:0031526	brush border membrane	Slc9a3	IDA		Rat	PMID:15238256|RGD:1581378
Cellular Component	GO:0070062	extracellular exosome	SLC9A3	IDA		Human	PMID:16501490
Cellular Component	GO:0070062	extracellular exosome	SLC9A3	HDA		Human	PMID:19056867
Cellular Component	GO:0005886	plasma membrane	SLC9A3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SLC9A3	IDA		Human	PMID:26358773
Cellular Component	GO:0005886	plasma membrane	SLC9A3	IDA		Human	PMID:35613257
Cellular Component	GO:0005886	plasma membrane	Slc9a3	IDA		Mouse	MGI:MGI:3603991|PMID:16141316
Cellular Component	GO:0055038	recycling endosome membrane	Slc9a3	IDA		Rat	PMID:9442041|RGD:155663515
Cellular Component	GO:0031982	vesicle	Slc9a3	IDA		Mouse	PMID:23863468
Biological Process	GO:0072488	ammonium transmembrane transport	slc9a3.2	IMP	ZFIN:ZDB-MRPHLNO-111219-3	Zfish	PMID:21832207
Biological Process	GO:0072488	ammonium transmembrane transport	slc9a3.2	IDA		Zfish	PMID:24401990
Biological Process	GO:0007623	circadian rhythm	Slc9a3	IEP		Rat	PMID:15780093|RGD:1581376
Biological Process	GO:0006898	receptor-mediated endocytosis	Slc9a3	IMP		Rat	PMID:15113744|RGD:1581379
Biological Process	GO:0051453	regulation of intracellular pH	SLC9A3	IDA		Human	PMID:35613257
Biological Process	GO:0006885	regulation of pH	Slc9a3	IDA		Mouse	PMID:10666043
Biological Process	GO:0006885	regulation of pH	Slc9a3	IDA		Rat	PMID:15265811|RGD:1625070
Biological Process	GO:0002028	regulation of sodium ion transport	Slc9a3	IMP		Rat	PMID:15238256|RGD:1581378
Biological Process	GO:0051384	response to glucocorticoid	Slc9a3	IEP		Rat	PMID:17095646|RGD:1625671
Biological Process	GO:0055078	sodium ion homeostasis	slc9a3.2	IMP	ZFIN:ZDB-MRPHLNO-120123-4	Zfish	PMID:23924428
Biological Process	GO:0098719	sodium ion import across plasma membrane	SLC9A3	IDA		Human	PMID:26358773
Biological Process	GO:0098719	sodium ion import across plasma membrane	slc9a3.2	IDA		Zfish	PMID:24401990
Biological Process	GO:0006814	sodium ion transport	Slc9a3	IDA		Mouse	PMID:10666043
Biological Process	GO:0006814	sodium ion transport	Slc9a3	IDA		Rat	PMID:11880335|RGD:737665
Biological Process	GO:0006814	sodium ion transport	slc9a3.2	IMP	ZFIN:ZDB-MRPHLNO-111219-3	Zfish	PMID:21832207
Biological Process	GO:0006814	sodium ion transport	slc9a3.2	IMP	ZFIN:ZDB-MRPHLNO-120123-4	Zfish	PMID:21993530

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern