Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLIT1
  • Mouse genes Slit1
  • Rat genes Slit1
  • Zfish genes slit1a,slit1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slit1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	Slit1	IDA		Rat	PMID:10364234|RGD:68764
Molecular Function	GO:0005515	protein binding	SLIT1	IPI	UniProtKB:P49639	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	SLIT1	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLIT1	IPI	UniProtKB:P49639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLIT1	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLIT1	IPI	UniProtKB:Q07627	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLIT1	IPI	UniProtKB:Q3SY46	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLIT1	IPI	UniProtKB:Q52LG2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLIT1	IPI	UniProtKB:Q5TD97	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLIT1	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLIT1	IPI	UniProtKB:Q6UY14-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLIT1	IPI	UniProtKB:Q6WN34-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLIT1	IPI	UniProtKB:Q6ZNG0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SLIT1	IPI	UniProtKB:Q8IWZ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Slit1	IPI	UniProtKB:O35793	Rat	PMID:15528323|RGD:2303400
Molecular Function	GO:0005515	protein binding	Slit1	IPI	UniProtKB:Q61477	Rat	PMID:15528323|RGD:2303400
Molecular Function	GO:0048495	Roundabout binding	SLIT1	IPI	UniProtKB:Q9HCK4	Human	PMID:15207848
Molecular Function	GO:0048495	Roundabout binding	SLIT1	IPI	UniProtKB:Q9Y6N7	Human	PMID:15207848
Molecular Function	GO:0048495	Roundabout binding	Slit1	IPI	UniProtKB:O55005	Mouse	PMID:10433822
Cellular Component	GO:0005615	extracellular space	Slit1	IDA		Mouse	PMID:12954717
Cellular Component	GO:0005615	extracellular space	Slit1	IDA		Rat	PMID:15632296|RGD:1358459
Biological Process	GO:0048846	axon extension involved in axon guidance	SLIT1	IDA		Human	PMID:16840550
Biological Process	GO:0007411	axon guidance	SLIT1	IDA		Human	PMID:11748139
Biological Process	GO:0007411	axon guidance	Slit1	IGI	MGI:MGI:1315205	Mouse	PMID:15091338
Biological Process	GO:0007411	axon guidance	Slit1	IGI	MGI:MGI:105088	Mouse	PMID:12051827
Biological Process	GO:0007411	axon guidance	Slit1	IGI	MGI:MGI:1315205	Mouse	PMID:11804571
Biological Process	GO:0007411	axon guidance	Slit1	IDA		Mouse	PMID:12954717
Biological Process	GO:0007411	axon guidance	Slit1	IGI	MGI:MGI:1315202	Mouse	PMID:15091338
Biological Process	GO:0007409	axonogenesis	Slit1	IDA		Mouse	PMID:12097499
Biological Process	GO:0007409	axonogenesis	Slit1	IMP	MGI:MGI:2179459	Mouse	PMID:12097499
Biological Process	GO:0007420	brain development	Slit1	IEP		Rat	PMID:11754167|RGD:2314870
Biological Process	GO:0021602	cranial nerve morphogenesis	slit1a	IMP	ZFIN:ZDB-MRPHLNO-050923-6	Zfish	PMID:25972174
Biological Process	GO:0021602	cranial nerve morphogenesis	slit1b	IMP	ZFIN:ZDB-MRPHLNO-070130-2	Zfish	PMID:25972174
Biological Process	GO:0033563	dorsal/ventral axon guidance	Slit1	IGI	MGI:MGI:1315205	Mouse	PMID:11804571
Biological Process	GO:0008045	motor neuron axon guidance	SLIT1	IMP		Human	PMID:16162649
Biological Process	GO:0050919	negative chemotaxis	SLIT1	IDA		Human	PMID:11748139
Biological Process	GO:0050919	negative chemotaxis	Slit1	IMP	MGI:MGI:2179459	Mouse	PMID:12097499
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	Slit1	IDA		Rat	PMID:15632296|RGD:1358459
Biological Process	GO:0048812	neuron projection morphogenesis	Slit1	IGI	MGI:MGI:1315205	Mouse	PMID:11804571
Biological Process	GO:0007097	nuclear migration	Slit1	IDA		Mouse	PMID:12051827
Biological Process	GO:0021772	olfactory bulb development	Slit1	IGI	MGI:MGI:1315205	Mouse	PMID:12097499
Biological Process	GO:0045773	positive regulation of axon extension	slit1a	IMP	ZFIN:ZDB-MRPHLNO-050923-6	Zfish	PMID:16033800
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Slit1	IGI	MGI:MGI:1315205	Mouse	PMID:11804570
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Slit1	IGI	MGI:MGI:1315205	Mouse	PMID:16885222
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Slit1	IMP	MGI:MGI:2179459	Mouse	PMID:16828733
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Slit1	IGI	MGI:MGI:1315205	Mouse	PMID:16828733
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Slit1	IMP	MGI:MGI:2179459	Mouse	PMID:16885222
Biological Process	GO:0021510	spinal cord development	Slit1	IEP		Rat	PMID:10102268|RGD:68763
Biological Process	GO:0022028	tangential migration from the subventricular zone to the olfactory bulb	Slit1	IMP	MGI:MGI:2179459	Mouse	PMID:14960623
Biological Process	GO:0022029	telencephalon cell migration	Slit1	IGI	MGI:MGI:1315205	Mouse	PMID:14960623

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern