Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLIT2
  • Mouse genes Slit2
  • Rat genes Slit2
  • Zfish genes slit2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slit2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045499	chemorepellent activity	Slit2	IMP	MGI:MGI:2179460	Mouse	PMID:14960623
Molecular Function	GO:0005095	GTPase inhibitor activity	SLIT2	IDA		Human	PMID:16439689
Molecular Function	GO:0005095	GTPase inhibitor activity	SLIT2	IDA		Human	PMID:19759280
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	Slit2	IDA		Rat	PMID:10364234|RGD:68764
Molecular Function	GO:0008201	heparin binding	SLIT2	IDA		Human	PMID:17062560
Molecular Function	GO:0042802	identical protein binding	SLIT2	IPI	UniProtKB:O94813	Human	PMID:19498462
Molecular Function	GO:0043237	laminin-1 binding	SLIT2	IDA		Human	PMID:10102268
Molecular Function	GO:0005515	protein binding	SLIT2	IPI	UniProtKB:O95631	Human	PMID:10102268
Molecular Function	GO:0005515	protein binding	SLIT2	IPI	UniProtKB:Q9Y6N7	Human	PMID:17848514
Molecular Function	GO:0005515	protein binding	Slit2	IPI	PR:Q62165	Mouse	PMID:23217742
Molecular Function	GO:0005515	protein binding	Slit2	IPI	UniProtKB:O35793	Rat	PMID:15528323|RGD:2303400
Molecular Function	GO:0005515	protein binding	Slit2	IPI	UniProtKB:Q61477	Rat	PMID:15528323|RGD:2303400
Molecular Function	GO:0042803	protein homodimerization activity	SLIT2	IDA		Human	PMID:19498462
Molecular Function	GO:0043394	proteoglycan binding	SLIT2	IPI	UniProtKB:P35053	Human	PMID:11375980
Molecular Function	GO:0048495	Roundabout binding	SLIT2	IPI	UniProtKB:O55005	Human	PMID:10102268
Molecular Function	GO:0048495	Roundabout binding	SLIT2	IPI	UniProtKB:Q9QZI3	Human	PMID:10102268
Molecular Function	GO:0048495	Roundabout binding	SLIT2	IPI	UniProtKB:Q9HCK4	Human	PMID:15207848
Molecular Function	GO:0048495	Roundabout binding	SLIT2	IPI	UniProtKB:Q9Y6N7	Human	PMID:15207848
Molecular Function	GO:0048495	Roundabout binding	SLIT2	IPI	UniProtKB:Q9Y6N7	Human	PMID:17848514
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Slit2	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0005737	cytoplasm	SLIT2	IDA		Human	PMID:18566128
Cellular Component	GO:0070062	extracellular exosome	SLIT2	HDA		Human	PMID:19056867
Cellular Component	GO:0005615	extracellular space	SLIT2	IDA		Human	PMID:16439689
Cellular Component	GO:0005615	extracellular space	SLIT2	IDA		Human	PMID:19005219
Cellular Component	GO:0005615	extracellular space	Slit2	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Slit2	IDA		Mouse	PMID:12954717
Cellular Component	GO:0005886	plasma membrane	Slit2	IDA		Rat	PMID:19783284|RGD:2316127
Biological Process	GO:0033564	anterior/posterior axon guidance	slit2	IMP	ZFIN:ZDB-GENO-110803-6	Zfish	PMID:19605629
Biological Process	GO:0003180	aortic valve morphogenesis	Slit2	IMP		Mouse	MGI:MGI:5913048|PMID:25691540
Biological Process	GO:0061364	apoptotic process involved in luteolysis	SLIT2	IEP		Human	PMID:18566128
Biological Process	GO:0048846	axon extension involved in axon guidance	SLIT2	IDA		Human	PMID:16840550
Biological Process	GO:0007411	axon guidance	SLIT2	IDA		Human	PMID:11748139
Biological Process	GO:0007411	axon guidance	Slit2	IGI	MGI:MGI:1315203	Mouse	PMID:15091338
Biological Process	GO:0007411	axon guidance	Slit2	IGI	MGI:MGI:894663	Mouse	PMID:14605369
Biological Process	GO:0007411	axon guidance	Slit2	IDA		Mouse	PMID:12879062
Biological Process	GO:0007411	axon guidance	Slit2	IMP	MGI:MGI:2179460	Mouse	PMID:11804571
Biological Process	GO:0007411	axon guidance	Slit2	IGI	MGI:MGI:1315203	Mouse	PMID:11804571
Biological Process	GO:0007411	axon guidance	Slit2	IGI	MGI:MGI:1315202	Mouse	PMID:15091338
Biological Process	GO:0007411	axon guidance	Slit2	IDA		Mouse	PMID:12954717
Biological Process	GO:0007411	axon guidance	slit2	IMP	ZFIN:ZDB-GENO-060825-3	Zfish	PMID:15110042
Biological Process	GO:0007411	axon guidance	slit2	IMP	ZFIN:ZDB-GENO-060825-3	Zfish	PMID:15229183
Biological Process	GO:0007411	axon guidance	slit2	IMP	ZFIN:ZDB-GENO-040621-3	Zfish	PMID:15716341
Biological Process	GO:0007414	axonal defasciculation	slit2	IMP	ZFIN:ZDB-GENO-060825-3	Zfish	PMID:15229183
Biological Process	GO:0007409	axonogenesis	Slit2	IMP	MGI:MGI:2179460	Mouse	PMID:12097499
Biological Process	GO:0007409	axonogenesis	Slit2	IDA		Mouse	PMID:12097499
Biological Process	GO:0007420	brain development	Slit2	IEP		Rat	PMID:11754167|RGD:2314870
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	SLIT2	IDA		Human	PMID:18345009
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	SLIT2	IMP		Human	PMID:19005219
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	SLIT2	IMP		Human	PMID:19351956
Biological Process	GO:0098609	cell-cell adhesion	Slit2	IGI	MGI:MGI:105088	Mouse	PMID:16439476
Biological Process	GO:0098609	cell-cell adhesion	Slit2	IMP	MGI:MGI:2179460	Mouse	PMID:16439476
Biological Process	GO:0071504	cellular response to heparin	SLIT2	IDA		Human	PMID:17062560
Biological Process	GO:0032870	cellular response to hormone stimulus	SLIT2	IEP		Human	PMID:18566128
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	slit2	IMP	ZFIN:ZDB-MRPHLNO-050927-2	Zfish	PMID:22956848
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	slit2	IGI	ZFIN:ZDB-MRPHLNO-050927-2,ZFIN:ZDB-MRPHLNO-050927-3	Zfish	PMID:22956848
Biological Process	GO:0021836	chemorepulsion involved in postnatal olfactory bulb interneuron migration	SLIT2	IDA		Human	PMID:15207848
Biological Process	GO:0021972	corticospinal neuron axon guidance through spinal cord	SLIT2	IMP		Human	PMID:10975526
Biological Process	GO:0033563	dorsal/ventral axon guidance	Slit2	IMP	MGI:MGI:2179460	Mouse	PMID:11804571
Biological Process	GO:0033563	dorsal/ventral axon guidance	Slit2	IGI	MGI:MGI:1315203	Mouse	PMID:11804571
Biological Process	GO:0003262	endocardial progenitor cell migration to the midline involved in heart field formation	slit2	IGI	ZFIN:ZDB-MRPHLNO-051212-1,ZFIN:ZDB-MRPHLNO-080708-7,ZFIN:ZDB-MRPHLNO-110628-2,ZFIN:ZDB-MRPHLNO-110628-4	Zfish	PMID:21385766
Biological Process	GO:0001701	in utero embryonic development	Slit2	IMP	MGI:MGI:2179460	Mouse	PMID:18829537
Biological Process	GO:0050929	induction of negative chemotaxis	SLIT2	IDA		Human	PMID:10197527
Biological Process	GO:0001822	kidney development	Slit2	IMP	MGI:MGI:5437102	Mouse	PMID:27002738
Biological Process	GO:0060763	mammary duct terminal end bud growth	Slit2	IMP	MGI:MGI:2179460	Mouse	PMID:16439476
Biological Process	GO:0060603	mammary gland duct morphogenesis	Slit2	IMP	MGI:MGI:2179460	Mouse	PMID:16439476
Biological Process	GO:0060603	mammary gland duct morphogenesis	Slit2	IGI	MGI:MGI:105088	Mouse	PMID:16439476
Biological Process	GO:0001656	metanephros development	Slit2	IMP	MGI:MGI:2179460	Mouse	PMID:15130495
Biological Process	GO:0001763	morphogenesis of a branching structure	slit2	IMP	ZFIN:ZDB-GENO-060825-3	Zfish	PMID:15229183
Biological Process	GO:0008045	motor neuron axon guidance	SLIT2	IDA		Human	PMID:10102268
Biological Process	GO:0050919	negative chemotaxis	SLIT2	IDA		Human	PMID:11748139
Biological Process	GO:0050919	negative chemotaxis	SLIT2	IMP		Human	PMID:19005219
Biological Process	GO:0050919	negative chemotaxis	Slit2	IMP	MGI:MGI:2179460	Mouse	PMID:14960623
Biological Process	GO:0050919	negative chemotaxis	Slit2	IMP	MGI:MGI:2179460	Mouse	PMID:12097499
Biological Process	GO:0030837	negative regulation of actin filament polymerization	SLIT2	IDA		Human	PMID:19759280
Biological Process	GO:0030517	negative regulation of axon extension	Slit2	IDA		Mouse	PMID:12879062
Biological Process	GO:0030517	negative regulation of axon extension	slit2	IMP	ZFIN:ZDB-MRPHLNO-050927-2	Zfish	PMID:16033800
Biological Process	GO:0030517	negative regulation of axon extension	slit2	IGI	ZFIN:ZDB-GENO-980202-1526,ZFIN:ZDB-MRPHLNO-050927-2	Zfish	PMID:16033800
Biological Process	GO:0030308	negative regulation of cell growth	SLIT2	IMP		Human	PMID:18829537
Biological Process	GO:0030336	negative regulation of cell migration	SLIT2	IMP		Human	PMID:18566128
Biological Process	GO:0030336	negative regulation of cell migration	SLIT2	IDA		Human	PMID:19005219
Biological Process	GO:0008285	negative regulation of cell population proliferation	Slit2	IGI	MGI:MGI:1315202	Mouse	PMID:18829537
Biological Process	GO:0090288	negative regulation of cellular response to growth factor stimulus	SLIT2	IDA		Human	PMID:16439689
Biological Process	GO:0070100	negative regulation of chemokine-mediated signaling pathway	SLIT2	IMP		Human	PMID:18829537
Biological Process	GO:0010596	negative regulation of endothelial cell migration	SLIT2	IDA		Human	PMID:18345009
Biological Process	GO:0010629	negative regulation of gene expression	Slit2	IGI	MGI:MGI:1315202	Mouse	PMID:18829537
Biological Process	GO:0050728	negative regulation of inflammatory response	Slit2	IMP		Rat	PMID:15215188|RGD:2316132
Biological Process	GO:0010593	negative regulation of lamellipodium assembly	SLIT2	IDA		Human	PMID:16439689
Biological Process	GO:0002689	negative regulation of leukocyte chemotaxis	SLIT2	IDA		Human	PMID:11309622
Biological Process	GO:0090027	negative regulation of monocyte chemotaxis	Slit2	IDA		Rat	PMID:15528323|RGD:2303400
Biological Process	GO:0071676	negative regulation of mononuclear cell migration	SLIT2	IDA		Human	PMID:16439689
Biological Process	GO:0090024	negative regulation of neutrophil chemotaxis	SLIT2	IDA		Human	PMID:19759280
Biological Process	GO:0001933	negative regulation of protein phosphorylation	SLIT2	IDA		Human	PMID:18345009
Biological Process	GO:0090260	negative regulation of retinal ganglion cell axon guidance	SLIT2	IDA		Human	PMID:17062560
Biological Process	GO:0051058	negative regulation of small GTPase mediated signal transduction	SLIT2	IDA		Human	PMID:16439689
Biological Process	GO:0071672	negative regulation of smooth muscle cell chemotaxis	SLIT2	IDA		Human	PMID:16439689
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	SLIT2	IDA		Human	PMID:16439689
Biological Process	GO:0043116	negative regulation of vascular permeability	SLIT2	IDA		Human	PMID:18345009
Biological Process	GO:0048812	neuron projection morphogenesis	Slit2	IGI	MGI:MGI:1315203	Mouse	PMID:11804571
Biological Process	GO:0048812	neuron projection morphogenesis	Slit2	IMP	MGI:MGI:2179460	Mouse	PMID:11804571
Biological Process	GO:0021772	olfactory bulb development	Slit2	IGI	MGI:MGI:1315203	Mouse	PMID:12097499
Biological Process	GO:0061360	optic chiasma development	slit2	IMP	ZFIN:ZDB-GENO-220728-6	Zfish	PMID:33994352
Biological Process	GO:0021631	optic nerve morphogenesis	slit2	IMP	ZFIN:ZDB-GENO-220728-6	Zfish	PMID:33994352
Biological Process	GO:0043065	positive regulation of apoptotic process	SLIT2	IMP		Human	PMID:18566128
Biological Process	GO:0003184	pulmonary valve morphogenesis	Slit2	IMP		Mouse	MGI:MGI:5913048|PMID:25691540
Biological Process	GO:0051414	response to cortisol	SLIT2	IEP		Human	PMID:18566128
Biological Process	GO:0031667	response to nutrient levels	Slit2	IEP		Rat	PMID:16497807|RGD:2316129
Biological Process	GO:0031290	retinal ganglion cell axon guidance	SLIT2	IDA		Human	PMID:10864954
Biological Process	GO:0031290	retinal ganglion cell axon guidance	SLIT2	IDA		Human	PMID:19498462
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Slit2	IGI	MGI:MGI:1315203	Mouse	PMID:16885222
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Slit2	IGI	MGI:MGI:1315203	Mouse	PMID:11804570
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Slit2	IMP	MGI:MGI:2179460	Mouse	PMID:16828733
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Slit2	IGI	MGI:MGI:1315203	Mouse	PMID:16828733
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Slit2	IMP	MGI:MGI:2179460	Mouse	PMID:16885222
Biological Process	GO:0035385	Roundabout signaling pathway	SLIT2	IMP		Human	PMID:18829537
Biological Process	GO:0021510	spinal cord development	Slit2	IEP		Rat	PMID:10102268|RGD:68763
Biological Process	GO:0022029	telencephalon cell migration	Slit2	IGI	MGI:MGI:1315203	Mouse	PMID:14960623
Biological Process	GO:0001657	ureteric bud development	SLIT2	IMP		Human	PMID:15130495
Biological Process	GO:0060412	ventricular septum morphogenesis	Slit2	IMP		Mouse	MGI:MGI:5913048|PMID:25691540

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern