Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SLIT3
  • Mouse genes Slit3
  • Rat genes Slit3
  • Zfish genes slit3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Slit3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048495	Roundabout binding	SLIT3	IPI	UniProtKB:Q9HCK4	Human	PMID:15207848
Molecular Function	GO:0048495	Roundabout binding	SLIT3	IPI	UniProtKB:Q9Y6N7	Human	PMID:15207848
Cellular Component	GO:0005615	extracellular space	SLIT3	IDA		Human	PMID:19741192
Cellular Component	GO:0005615	extracellular space	Slit3	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Slit3	IDA		Mouse	PMID:12954717
Cellular Component	GO:0016020	membrane	Slit3	IDA		Rat	PMID:11443047|RGD:724720
Cellular Component	GO:0005739	mitochondrion	Slit3	IDA		Rat	PMID:11443047|RGD:724720
Biological Process	GO:0009887	animal organ morphogenesis	Slit3	IGI	MGI:MGI:1315203	Mouse	PMID:15091338
Biological Process	GO:0009887	animal organ morphogenesis	Slit3	IGI	MGI:MGI:1315205	Mouse	PMID:15091338
Biological Process	GO:0009887	animal organ morphogenesis	Slit3	IMP	MGI:MGI:2679499	Mouse	PMID:14550534
Biological Process	GO:0003180	aortic valve morphogenesis	Slit3	IMP		Mouse	MGI:MGI:5913048|PMID:25691540
Biological Process	GO:0061364	apoptotic process involved in luteolysis	SLIT3	IEP		Human	PMID:18566128
Biological Process	GO:0003181	atrioventricular valve morphogenesis	Slit3	IMP		Mouse	MGI:MGI:5913048|PMID:25691540
Biological Process	GO:0048846	axon extension involved in axon guidance	SLIT3	IDA		Human	PMID:16840550
Biological Process	GO:0007411	axon guidance	SLIT3	IDA		Human	PMID:11748139
Biological Process	GO:0007411	axon guidance	Slit3	IDA		Mouse	PMID:12954717
Biological Process	GO:0007420	brain development	Slit3	IEP		Rat	PMID:11754167|RGD:2314870
Biological Process	GO:0032870	cellular response to hormone stimulus	SLIT3	IEP		Human	PMID:18566128
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	slit3	IGI	ZFIN:ZDB-MRPHLNO-050927-2,ZFIN:ZDB-MRPHLNO-050927-3	Zfish	PMID:22956848
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	slit3	IMP	ZFIN:ZDB-MRPHLNO-050927-3	Zfish	PMID:22956848
Biological Process	GO:0050919	negative chemotaxis	SLIT3	IDA		Human	PMID:11748139
Biological Process	GO:0030517	negative regulation of axon extension	slit3	IGI	ZFIN:ZDB-GENO-980202-1526,ZFIN:ZDB-MRPHLNO-050927-3	Zfish	PMID:16033800
Biological Process	GO:0030517	negative regulation of axon extension	slit3	IMP	ZFIN:ZDB-MRPHLNO-050927-3	Zfish	PMID:16033800
Biological Process	GO:0030308	negative regulation of cell growth	SLIT3	IMP		Human	PMID:18829537
Biological Process	GO:0008285	negative regulation of cell population proliferation	Slit3	IGI	MGI:MGI:1315205	Mouse	PMID:18829537
Biological Process	GO:0070100	negative regulation of chemokine-mediated signaling pathway	SLIT3	IMP		Human	PMID:18829537
Biological Process	GO:0010629	negative regulation of gene expression	Slit3	IGI	MGI:MGI:1315205	Mouse	PMID:18829537
Biological Process	GO:0051414	response to cortisol	SLIT3	IEP		Human	PMID:18566128
Biological Process	GO:0035385	Roundabout signaling pathway	SLIT3	IMP		Human	PMID:18829537
Biological Process	GO:0021510	spinal cord development	Slit3	IEP		Rat	PMID:10102268|RGD:68763
Biological Process	GO:0060412	ventricular septum morphogenesis	Slit3	IMP		Mouse	MGI:MGI:5913048|PMID:25691540

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern