Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMAD2
  • Mouse genes Smad2
  • Rat genes Smad2
  • Zfish genes smad2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smad2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Smad2	IDA		Mouse	PMID:15657445
Molecular Function	GO:0003682	chromatin binding	Smad2	IDA		Mouse	PMID:16619037
Molecular Function	GO:0070410	co-SMAD binding	SMAD2	IPI	UniProtKB:Q13485	Human	PMID:9111321
Molecular Function	GO:0070410	co-SMAD binding	SMAD2	IPI	UniProtKB:Q13485	Human	PMID:9311995
Molecular Function	GO:0097718	disordered domain specific binding	SMAD2	IPI	UniProtKB:O95405	Human	PMID:15231848
Molecular Function	GO:0003677	DNA binding	SMAD2	IDA		Human	PMID:9389648
Molecular Function	GO:0003677	DNA binding	Smad2	IDA		Mouse	MGI:MGI:6252929|PMID:27336669
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	SMAD2	IDA		Human	PMID:31582430
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	SMAD2	IDA		Human	PMID:9389648
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Smad2	IPI	ENSEMBL_GeneID:ENSG00000127445	Mouse	MGI:MGI:6158712|PMID:24964035
Molecular Function	GO:0003700	DNA-binding transcription factor activity	SMAD2	IDA		Human	PMID:17438144
Molecular Function	GO:0003700	DNA-binding transcription factor activity	SMAD2	IDA		Human	PMID:9389648
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	smad2	IDA		Zfish	PMID:28778986
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	smad2	IMP	ZFIN:ZDB-MRPHLNO-070529-5	Zfish	PMID:17306248
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SMAD2	IPI	UniProtKB:Q02078	Human	PMID:11160896
Molecular Function	GO:0140297	DNA-binding transcription factor binding	SMAD2	IPI	UniProtKB:O75593	Human	PMID:9702198
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Smad2	IPI	UniProtKB:O88621	Mouse	MGI:MGI:1276222|PMID:9702197
Molecular Function	GO:0003690	double-stranded DNA binding	Smad2	IDA		Mouse	PMID:15282343
Molecular Function	GO:0070411	I-SMAD binding	SMAD2	IPI	UniProtKB:O43541	Human	PMID:9256479
Molecular Function	GO:0042802	identical protein binding	Smad2	IPI	PR:Q62432	Mouse	PMID:21724602
Molecular Function	GO:0019902	phosphatase binding	SMAD2	IPI	UniProtKB:P35813	Human	PMID:16751101
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:O95405	Human	PMID:10615055
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q13573	Human	PMID:11278756
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P98082	Human	PMID:11387212
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P12757-1	Human	PMID:12764135
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P12755	Human	PMID:15107821
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:O95405	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q12955	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q13485	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9HAU4	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q13485	Human	PMID:15350224
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9Y2U8	Human	PMID:15647271
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q2VWA4	Human	PMID:16200078
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P35813	Human	PMID:16751101
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q93062	Human	PMID:17099224
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P84550	Human	PMID:17292623
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:O15111	Human	PMID:18268325
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:O95405	Human	PMID:18511908
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q13485	Human	PMID:18511908
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9GZV5	Human	PMID:18568018
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:O00308	Human	PMID:18729074
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P12755	Human	PMID:18729074
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P84022	Human	PMID:18729074
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q13485	Human	PMID:18729074
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q13573	Human	PMID:18729074
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9BZ29	Human	PMID:18729074
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9HAU4	Human	PMID:18729074
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P52926	Human	PMID:18832382
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q8TAK6	Human	PMID:18923419
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P12755	Human	PMID:19032343
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9HAZ2	Human	PMID:19049980
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q13526	Human	PMID:19122240
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q13485	Human	PMID:19135894
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9UPN9	Human	PMID:19135894
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9H6Z4	Human	PMID:19289081
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P04637	Human	PMID:19345189
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9H3D4	Human	PMID:19345189
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9NYA4	Human	PMID:20061380
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q969W9	Human	PMID:20129061
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P05060	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P05412	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P07197	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P61586	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q12955	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q96KR1	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q13485	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9UPN9	Human	PMID:20603019
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9HAU4	Human	PMID:20937913
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:O00308	Human	PMID:21258410
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q13485	Human	PMID:21297662
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q13485	Human	PMID:21532621
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9UK33	Human	PMID:21599657
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9H3D4	Human	PMID:21741598
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9Y4E8	Human	PMID:21947082
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9H6Z4	Human	PMID:21960005
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P84022	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q13485	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q9HAU4	Human	PMID:22045334
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P12755	Human	PMID:22442258
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q13485	Human	PMID:22442258
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:O15165	Human	PMID:24627487
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P04637	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P05412	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q13485	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P04637	Human	PMID:25670079
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P12755	Human	PMID:26977879
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:O75593	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:O75593	Human	PMID:9389648
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P70056	Human	PMID:9389648
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:Q13485	Human	PMID:9389648
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:O75593	Human	PMID:9702198
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:O95405	Human	PMID:9865696
Molecular Function	GO:0005515	protein binding	SMAD2	IPI	UniProtKB:P36896	Human	PMID:9892009
Molecular Function	GO:0005515	protein binding	Smad2	IPI	UniProtKB:P46938|UniProtKB:P97471	Mouse	MGI:MGI:4939579|PMID:21145499
Molecular Function	GO:0005515	protein binding	Smad2	IPI	PR:O35295	Mouse	PMID:15282343
Molecular Function	GO:0005515	protein binding	Smad2	IPI	PR:O88621	Mouse	PMID:9702197
Molecular Function	GO:0005515	protein binding	Smad2	IPI	PR:P42669	Mouse	PMID:15282343
Molecular Function	GO:0005515	protein binding	Smad2	IPI	PR:Q8CHP0	Mouse	PMID:16115198
Molecular Function	GO:0005515	protein binding	Smad2	IPI	MGI:MGI:2441856	Mouse	PMID:14651998
Molecular Function	GO:0005515	protein binding	Smad2	IPI	PR:Q9EST3	Mouse	PMID:14651998
Molecular Function	GO:0005515	protein binding	Smad2	IPI	PR:P97471	Mouse	PMID:21724602
Molecular Function	GO:0005515	protein binding	Smad2	IPI	PR:O35740	Mouse	PMID:16619037
Molecular Function	GO:0005515	protein binding	Smad2	IPI	PR:O70477	Mouse	PMID:14764653
Molecular Function	GO:0005515	protein binding	Smad2	IPI	PR:Q99LC9	Mouse	PMID:14651998
Molecular Function	GO:0005515	protein binding	Smad2	IPI	PR:Q9CU65	Mouse	PMID:14651998
Molecular Function	GO:0005515	protein binding	Smad2	IPI	PR:P41778	Mouse	PMID:14764653
Molecular Function	GO:0005515	protein binding	Smad2	IPI	UniProtKB:P47196	Rat	PMID:16362038|RGD:8553856
Molecular Function	GO:0005515	protein binding	Smad2	IPI	UniProtKB:O35740	Rat	PMID:16619037|RGD:8554622
Molecular Function	GO:0005515	protein binding	Smad2	IPI	RGD:2401	Rat	PMID:16959941|RGD:1599906
Molecular Function	GO:0005515	protein binding	smad2	IPI	ZFIN:ZDB-GENE-030131-3200	Zfish	PMID:26041917
Molecular Function	GO:0005515	protein binding	smad2	IPI	ZFIN:ZDB-GENE-041121-18	Zfish	PMID:28778986
Molecular Function	GO:0070412	R-SMAD binding	SMAD2	IPI	UniProtKB:P84022	Human	PMID:9311995
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SMAD2	IDA		Human	PMID:31582430
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SMAD2	IDA		Human	PMID:9389648
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	smad2	IDA		Zfish	PMID:29275993
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Smad2	IPI	UniProtKB:B7ZQJ9	Mouse	MGI:MGI:4399035|PMID:11937490
Molecular Function	GO:0043565	sequence-specific DNA binding	smad2	IDA		Zfish	PMID:23950494
Molecular Function	GO:0046332	SMAD binding	SMAD2	IPI	UniProtKB:Q06413	Human	PMID:11160896
Molecular Function	GO:0046332	SMAD binding	Smad2	IPI	UniProtKB:Q60929	Mouse	MGI:MGI:5009194|PMID:11160896
Molecular Function	GO:0048156	tau protein binding	Smad2	IDA		Mouse	MGI:MGI:6158712|PMID:24964035
Molecular Function	GO:0005160	transforming growth factor beta receptor binding	SMAD2	IPI	UniProtKB:P36897	Human	PMID:9311995
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	SMAD2	IPI	UniProtKB:P36897	Human	PMID:8980228
Molecular Function	GO:0031625	ubiquitin protein ligase binding	SMAD2	IPI	UniProtKB:Q9HAU4	Human	PMID:19122240
Cellular Component	GO:0032444	activin responsive factor complex	SMAD2	IDA		Human	PMID:9389648
Cellular Component	GO:0000785	chromatin	SMAD2	IDA		Human	PMID:21828274
Cellular Component	GO:0000785	chromatin	smad2	IDA		Zfish	PMID:29275993
Cellular Component	GO:0005737	cytoplasm	SMAD2	IDA		Human	PMID:12411310
Cellular Component	GO:0005737	cytoplasm	SMAD2	IDA		Human	PMID:21145499
Cellular Component	GO:0005737	cytoplasm	SMAD2	IDA		Human	PMID:9311995
Cellular Component	GO:0005737	cytoplasm	SMAD2	IDA		Human	PMID:9389648
Cellular Component	GO:0005737	cytoplasm	Smad2	IDA		Mouse	MGI:MGI:6158712|PMID:24964035
Cellular Component	GO:0005737	cytoplasm	Smad2	IDA		Mouse	MGI:MGI:4939579|PMID:21145499
Cellular Component	GO:0005737	cytoplasm	Smad2	IDA		Mouse	MGI:MGI:2683382|PMID:14691138
Cellular Component	GO:0005737	cytoplasm	Smad2	IDA		Rat	PMID:16570350|RGD:1599901
Cellular Component	GO:0071144	heteromeric SMAD protein complex	SMAD2	IPI		Human	PMID:15350224
Cellular Component	GO:0071144	heteromeric SMAD protein complex	SMAD2	IDA		Human	PMID:21828274
Cellular Component	GO:0071142	homomeric SMAD protein complex	SMAD2	IPI		Human	PMID:11779503
Cellular Component	GO:0005634	nucleus	SMAD2	IDA		Human	PMID:12411310
Cellular Component	GO:0005634	nucleus	SMAD2	IDA		Human	PMID:16751101
Cellular Component	GO:0005634	nucleus	SMAD2	IDA		Human	PMID:21145499
Cellular Component	GO:0005634	nucleus	SMAD2	IDA		Human	PMID:21599657
Cellular Component	GO:0005634	nucleus	SMAD2	IDA		Human	PMID:25893292
Cellular Component	GO:0005634	nucleus	SMAD2	IDA		Human	PMID:8980228
Cellular Component	GO:0005634	nucleus	SMAD2	IDA		Human	PMID:9311995
Cellular Component	GO:0005634	nucleus	SMAD2	IDA		Human	PMID:9389648
Cellular Component	GO:0005634	nucleus	Smad2	IDA		Mouse	MGI:MGI:4939579|PMID:21145499
Cellular Component	GO:0005634	nucleus	Smad2	IDA		Mouse	MGI:MGI:5009194|PMID:11160896
Cellular Component	GO:0005634	nucleus	Smad2	IDA		Mouse	MGI:MGI:6158712|PMID:24964035
Cellular Component	GO:0005634	nucleus	Smad2	IDA		Mouse	MGI:MGI:2683382|PMID:14691138
Cellular Component	GO:0005634	nucleus	Smad2	IDA		Mouse	PMID:21300867
Cellular Component	GO:0005634	nucleus	Smad2	IDA		Rat	PMID:18684975|RGD:2302517
Cellular Component	GO:0005634	nucleus	smad2	IDA		Zfish	PMID:28778986
Cellular Component	GO:0032991	protein-containing complex	SMAD2	IMP		Human	PMID:15231848
Cellular Component	GO:0032991	protein-containing complex	Smad2	IDA		Rat	PMID:16959941|RGD:1599906
Cellular Component	GO:0071141	SMAD protein complex	SMAD2	IDA		Human	PMID:18832382
Cellular Component	GO:0005667	transcription regulator complex	SMAD2	IDA		Human	PMID:17438144
Cellular Component	GO:0005667	transcription regulator complex	Smad2	IDA		Mouse	PMID:9702197
Cellular Component	GO:0005667	transcription regulator complex	Smad2	IDA		Mouse	PMID:17568773
Biological Process	GO:0032924	activin receptor signaling pathway	SMAD2	IMP		Human	PMID:15150278
Biological Process	GO:0030325	adrenal gland development	Smad2	IDA		Rat	PMID:12844345|RGD:728125
Biological Process	GO:0009952	anterior/posterior pattern specification	Smad2	IMP	MGI:MGI:1857691	Mouse	PMID:11418863
Biological Process	GO:0009952	anterior/posterior pattern specification	Smad2	IMP	MGI:MGI:1857691	Mouse	PMID:9529255
Biological Process	GO:0009952	anterior/posterior pattern specification	Smad2	IMP	MGI:MGI:2668416	Mouse	PMID:12842913
Biological Process	GO:0003180	aortic valve morphogenesis	Smad2	IGI	UniProtKB:Q9R001	Mouse	MGI:MGI:5693221|PMID:23531444
Biological Process	GO:0045165	cell fate commitment	Smad2	IMP	MGI:MGI:2668416	Mouse	PMID:12842913
Biological Process	GO:0007182	common-partner SMAD protein phosphorylation	SMAD2	IDA		Human	PMID:16806156
Biological Process	GO:0060028	convergent extension involved in axis elongation	smad2	IGI	ZFIN:ZDB-GENE-060804-3,ZFIN:ZDB-GENE-030912-14,ZFIN:ZDB-GENE-051113-276	Zfish	PMID:28076796
Biological Process	GO:0060028	convergent extension involved in axis elongation	smad2	IMP		Zfish	PMID:28076796
Biological Process	GO:0060028	convergent extension involved in axis elongation	smad2	IGI	ZFIN:ZDB-GENE-030912-14,ZFIN:ZDB-GENE-051113-276	Zfish	PMID:28076796
Biological Process	GO:0060028	convergent extension involved in axis elongation	smad2	IGI	ZFIN:ZDB-GENE-060804-3,ZFIN:ZDB-GENE-030912-14	Zfish	PMID:28076796
Biological Process	GO:0060028	convergent extension involved in axis elongation	smad2	IGI	ZFIN:ZDB-GENE-060804-3	Zfish	PMID:28076796
Biological Process	GO:0060028	convergent extension involved in axis elongation	smad2	IGI	ZFIN:ZDB-GENE-051113-276	Zfish	PMID:28076796
Biological Process	GO:0060028	convergent extension involved in axis elongation	smad2	IMP	ZFIN:ZDB-MRPHLNO-180411-2	Zfish	PMID:28076796
Biological Process	GO:0048589	developmental growth	Smad2	IGI	MGI:MGI:1201674	Mouse	PMID:15183723
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Smad2	IGI	MGI:MGI:1201674	Mouse	PMID:15183723
Biological Process	GO:0048617	embryonic foregut morphogenesis	Smad2	IGI	MGI:MGI:1201674	Mouse	PMID:15183723
Biological Process	GO:0009880	embryonic pattern specification	Smad2	IGI	MGI:MGI:1201674	Mouse	PMID:15183723
Biological Process	GO:0009880	embryonic pattern specification	smad2	IMP		Zfish	PMID:10767528|ZFIN:ZDB-PUB-000505-18
Biological Process	GO:0003203	endocardial cushion morphogenesis	Smad2	IGI	UniProtKB:Q9R001	Mouse	MGI:MGI:5693221|PMID:23531444
Biological Process	GO:0007492	endoderm development	Smad2	IGI	MGI:MGI:1201674	Mouse	PMID:15183723
Biological Process	GO:0001706	endoderm formation	Smad2	IMP		Mouse	PMID:21822279
Biological Process	GO:0007369	gastrulation	Smad2	IGI	MGI:MGI:1201674	Mouse	PMID:15183723
Biological Process	GO:0007507	heart development	Smad2	IGI	MGI:MGI:87912	Mouse	PMID:17849440
Biological Process	GO:0001701	in utero embryonic development	Smad2	IMP	MGI:MGI:1857692	Mouse	PMID:17849440
Biological Process	GO:0001701	in utero embryonic development	Smad2	IGI	MGI:MGI:1201674	Mouse	PMID:15183723
Biological Process	GO:0030073	insulin secretion	Smad2	IGI	MGI:MGI:87912	Mouse	PMID:17849440
Biological Process	GO:0035556	intracellular signal transduction	Smad2	IDA		Mouse	PMID:14749725
Biological Process	GO:0035556	intracellular signal transduction	smad2	IGI	ZFIN:ZDB-GENE-990415-181	Zfish	PMID:10767528|ZFIN:ZDB-PUB-000505-18
Biological Process	GO:0030324	lung development	Smad2	IGI	MGI:MGI:87912	Mouse	PMID:17849440
Biological Process	GO:0001707	mesoderm formation	Smad2	IMP	MGI:MGI:1857691	Mouse	PMID:15084457
Biological Process	GO:0008285	negative regulation of cell population proliferation	Smad2	IMP		Rat	PMID:15987742|RGD:2300418
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	SMAD2	IMP		Human	PMID:14555988
Biological Process	GO:0010629	negative regulation of gene expression	Smad2	IMP		Mouse	PMID:23152446
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	smad2	IMP	ZFIN:ZDB-MRPHLNO-070529-5	Zfish	PMID:17306248
Biological Process	GO:0021999	neural plate anterior/posterior regionalization	smad2	IGI	ZFIN:ZDB-GENE-030131-3200	Zfish	PMID:26041917
Biological Process	GO:0038092	nodal signaling pathway	SMAD2	IMP		Human	PMID:15150278
Biological Process	GO:0038092	nodal signaling pathway	smad2	IMP	ZFIN:ZDB-MRPHLNO-170501-1	Zfish	PMID:28778986
Biological Process	GO:0038092	nodal signaling pathway	smad2	IDA		Zfish	PMID:28778986
Biological Process	GO:0035265	organ growth	Smad2	IGI	MGI:MGI:87912	Mouse	PMID:17849440
Biological Process	GO:0031016	pancreas development	Smad2	IGI	MGI:MGI:87912	Mouse	PMID:17849440
Biological Process	GO:0048340	paraxial mesoderm morphogenesis	Smad2	IMP	MGI:MGI:1857691	Mouse	PMID:15084457
Biological Process	GO:0007389	pattern specification process	Smad2	IGI	MGI:MGI:87912	Mouse	PMID:17849440
Biological Process	GO:0060039	pericardium development	Smad2	IGI	MGI:MGI:1201674	Mouse	PMID:15183723
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	SMAD2	IMP		Human	PMID:19366699
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	SMAD2	IMP		Human	PMID:14555988
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	SMAD2	IDA		Human	PMID:9311995
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	SMAD2	IDA		Human	PMID:9389648
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	SMAD2	IDA		Human	PMID:9732876
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Smad2	IMP		Mouse	MGI:MGI:2683382|PMID:14691138
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Smad2	IDA		Mouse	PMID:15282343
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	Smad2	IMP		Mouse	MGI:MGI:2683382|PMID:14691138
Biological Process	GO:0010628	positive regulation of gene expression	Smad2	IMP		Mouse	PMID:23152446
Biological Process	GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	SMAD2	IMP		Human	PMID:17239842
Biological Process	GO:0060282	positive regulation of oocyte development	smad2	IMP	ZFIN:ZDB-MRPHLNO-070529-5	Zfish	PMID:18838125
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	SMAD2	IDA		Human	PMID:9389648
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smad2	IGI	MGI:MGI:98725	Mouse	PMID:17568773
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smad2	IGI	MGI:MGI:98727	Mouse	PMID:17159989
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smad2	IGI	MGI:MGI:1347465	Mouse	PMID:17568773
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smad2	IGI	MGI:MGI:1314872	Mouse	PMID:17159989
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smad2	IDA		Mouse	PMID:9702197
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smad2	IGI	MGI:MGI:1201674	Mouse	PMID:23390484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smad2	IGI	MGI:MGI:894293	Mouse	PMID:17159989
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smad2	IGI	MGI:MGI:1201674	Mouse	PMID:17159989
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smad2	IMP		Rat	PMID:22073128|RGD:8554355
Biological Process	GO:0009791	post-embryonic development	Smad2	IGI	MGI:MGI:87912	Mouse	PMID:17849440
Biological Process	GO:0006468	protein phosphorylation	Smad2	IDA		Mouse	PMID:18990706
Biological Process	GO:0003184	pulmonary valve morphogenesis	Smad2	IGI	UniProtKB:Q9R001	Mouse	MGI:MGI:5693221|PMID:23531444
Biological Process	GO:0051098	regulation of binding	Smad2	IDA		Mouse	PMID:15282343
Biological Process	GO:0006355	regulation of DNA-templated transcription	smad2	IPI	ZFIN:ZDB-GENE-000616-6	Zfish	PMID:21159776
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	smad2	IGI	ZFIN:ZDB-GENE-000616-15	Zfish	PMID:17306248
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	SMAD2	IMP		Human	PMID:14555988
Biological Process	GO:0070723	response to cholesterol	SMAD2	IDA		Human	PMID:17878231
Biological Process	GO:0009749	response to glucose	Smad2	IGI	MGI:MGI:87912	Mouse	PMID:17849440
Biological Process	GO:0062009	secondary palate development	Smad2	IMP		Mouse	MGI:MGI:2683382|PMID:14691138
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	Smad2	IMP		Rat	PMID:22073128|RGD:8554355
Biological Process	GO:0007183	SMAD protein complex assembly	SMAD2	IDA		Human	PMID:9111321
Biological Process	GO:0060395	SMAD protein signal transduction	Smad2	IGI	MGI:MGI:1201674	Mouse	PMID:23390484
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	SMAD2	IDA		Human	PMID:18548003
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	SMAD2	IDA		Human	PMID:8752209
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	SMAD2	IMP		Human	PMID:8980228
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	SMAD2	IDA		Human	PMID:9389648
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	SMAD2	IDA		Human	PMID:9732876
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Smad2	IDA		Mouse	PMID:11557747
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Smad2	IGI	MGI:MGI:894293	Mouse	PMID:18212064
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Smad2	IGI	MGI:MGI:98725	Mouse	PMID:18212064
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Smad2	IDA		Mouse	PMID:14749725
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Smad2	IGI	MGI:MGI:98834	Mouse	PMID:18212064
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Smad2	IMP		Rat	PMID:22073128|RGD:8554355
Biological Process	GO:0001657	ureteric bud development	Smad2	IEP		Mouse	MGI:MGI:3525982|PMID:14656760
Biological Process	GO:0042060	wound healing	Smad2	IEP		Rat	PMID:15980223|RGD:12903273
Biological Process	GO:0007352	zygotic specification of dorsal/ventral axis	SMAD2	IMP		Human	PMID:9436979

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern