Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMAD7
  • Mouse genes Smad7
  • Rat genes Smad7
  • Zfish genes smad7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smad7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048185	activin binding	SMAD7	IPI	UniProtKB:P36896	Human	PMID:16720724
Molecular Function	GO:0008013	beta-catenin binding	SMAD7	IPI	UniProtKB:P35222	Human	PMID:18593713
Molecular Function	GO:0005518	collagen binding	Smad7	IPI	PR:Q01149	Mouse	PMID:14559231
Molecular Function	GO:0005518	collagen binding	Smad7	IPI	PR:Q3U962	Mouse	PMID:14559231
Molecular Function	GO:0005518	collagen binding	Smad7	IPI	PR:P08121	Mouse	PMID:14559231
Molecular Function	GO:0070411	I-SMAD binding	SMAD7	IPI	UniProtKB:O43541	Human	PMID:9256479
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:Q92905	Human	PMID:14993265
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:Q9HAU4	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:O15169	Human	PMID:16601693
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:Q99ML9	Human	PMID:16601693
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:P36896	Human	PMID:16720724
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:P62942	Human	PMID:16720724
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:O15169	Human	PMID:18593713
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:O43294	Human	PMID:18762808
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:Q9HAU4	Human	PMID:20937913
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:Q9HCE7-1	Human	PMID:20937913
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:O00308	Human	PMID:21258410
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:Q9Y4E8	Human	PMID:22344298
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:P46937	Human	PMID:22921829
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:Q96PU5-5	Human	PMID:22921829
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:Q9HAU4	Human	PMID:22921829
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:Q9HCE7-1	Human	PMID:22921829
Molecular Function	GO:0005515	protein binding	SMAD7	IPI	UniProtKB:P46937	Human	PMID:25283809
Molecular Function	GO:0005515	protein binding	Smad7	IPI	UniProtKB:Q9C0C9	Mouse	MGI:MGI:5508676|PMID:23455153
Molecular Function	GO:0005515	protein binding	Smad7	IPI	UniProtKB:Q923E4	Mouse	MGI:MGI:5306300|PMID:17098745
Molecular Function	GO:0005515	protein binding	Smad7	IPI	PR:O35625	Mouse	PMID:16601693
Molecular Function	GO:0005515	protein binding	Smad7	IPI	PR:O88566	Mouse	PMID:16601693
Molecular Function	GO:0005515	protein binding	Smad7	IPI	UniProtKB:Q99PD6	Rat	PMID:18762808|RGD:8553475
Molecular Function	GO:0140416	transcription regulator inhibitor activity	SMAD7	IDA		Human	PMID:9256479
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	SMAD7	IPI	UniProtKB:P36897	Human	PMID:11278251
Molecular Function	GO:0031625	ubiquitin protein ligase binding	SMAD7	IPI	UniProtKB:Q9HCE7	Human	PMID:12151385
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Smad7	IPI	RGD:1310067|RGD:1310097	Rat	PMID:17347560|RGD:2302562
Cellular Component	GO:0005912	adherens junction	SMAD7	IDA		Human	PMID:18593713
Cellular Component	GO:0005813	centrosome	SMAD7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005737	cytoplasm	SMAD7	IDA		Human	PMID:11278251
Cellular Component	GO:0005737	cytoplasm	SMAD7	IDA		Human	PMID:17438144
Cellular Component	GO:0005829	cytosol	SMAD7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001650	fibrillar center	SMAD7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SMAD7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SMAD7	IDA		Human	PMID:11278251
Cellular Component	GO:0005634	nucleus	SMAD7	IDA		Human	PMID:12151385
Cellular Component	GO:0005634	nucleus	SMAD7	IDA		Human	PMID:17438144
Cellular Component	GO:0005634	nucleus	Smad7	IDA		Mouse	PMID:16601693
Cellular Component	GO:0005634	nucleus	Smad7	IDA		Mouse	PMID:19796622
Cellular Component	GO:0005886	plasma membrane	SMAD7	IDA		Human	PMID:12151385
Cellular Component	GO:0032991	protein-containing complex	SMAD7	IDA		Human	PMID:23610558
Cellular Component	GO:0032991	protein-containing complex	Smad7	IDA		Mouse	PMID:16601693
Biological Process	GO:0034333	adherens junction assembly	SMAD7	IMP		Human	PMID:18593713
Biological Process	GO:0048844	artery morphogenesis	Smad7	IMP		Mouse	MGI:MGI:3836072|PMID:18952608
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Smad7	IEP		Mouse	PMID:20439489
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	SMAD7	IMP		Human	PMID:18593713
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Smad7	IMP		Mouse	MGI:MGI:5532916|PMID:18593713
Biological Process	GO:0035556	intracellular signal transduction	Smad7	IDA		Rat	PMID:11959632|RGD:625758
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	SMAD7	IDA		Human	PMID:17438144
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Smad7	IDA		Mouse	PMID:19850029
Biological Process	GO:1902731	negative regulation of chondrocyte proliferation	Smad7	IDA		Mouse	MGI:MGI:6377914|PMID:29503843
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	SMAD7	IDA		Human	PMID:17438144
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Smad7	IEP		Rat	PMID:11959632|RGD:625758
Biological Process	GO:0030279	negative regulation of ossification	Smad7	IDA		Mouse	MGI:MGI:6377914|PMID:29503843
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	SMAD7	IDA		Human	PMID:17438144
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	SMAD7	IDA		Human	PMID:18593713
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	Smad7	IMP		Mouse	MGI:MGI:5532916|PMID:18593713
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	SMAD7	IDA		Human	PMID:18593713
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	Smad7	IMP		Mouse	MGI:MGI:5532916|PMID:18593713
Biological Process	GO:0031397	negative regulation of protein ubiquitination	SMAD7	IDA		Human	PMID:18593713
Biological Process	GO:0002725	negative regulation of T cell cytokine production	Smad7	IMP		Mouse	MGI:MGI:5634593|PMID:25642768
Biological Process	GO:2000320	negative regulation of T-helper 17 cell differentiation	Smad7	IMP		Mouse	MGI:MGI:5634593|PMID:25642768
Biological Process	GO:2000317	negative regulation of T-helper 17 type immune response	Smad7	IMP		Mouse	MGI:MGI:5634593|PMID:25642768
Biological Process	GO:0010944	negative regulation of transcription by competitive promoter binding	SMAD7	IDA		Human	PMID:17438144
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SMAD7	IDA		Human	PMID:17438144
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	SMAD7	IDA		Human	PMID:12151385
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	SMAD7	IDA		Human	PMID:17438144
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	SMAD7	IDA		Human	PMID:18762808
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	SMAD7	IDA		Human	PMID:9256479
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity	SMAD7	IDA		Human	PMID:18593713
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	Smad7	IMP		Mouse	MGI:MGI:3836072|PMID:18952608
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	SMAD7	IDA		Human	PMID:18593713
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	Smad7	IMP		Mouse	MGI:MGI:5532916|PMID:18593713
Biological Process	GO:1903043	positive regulation of chondrocyte hypertrophy	Smad7	IDA		Mouse	MGI:MGI:6377914|PMID:29503843
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	SMAD7	IDA		Human	PMID:11278251
Biological Process	GO:0031398	positive regulation of protein ubiquitination	SMAD7	IDA		Human	PMID:16720724
Biological Process	GO:0050821	protein stabilization	SMAD7	IDA		Human	PMID:18593713
Biological Process	GO:0031503	protein-containing complex localization	SMAD7	IDA		Human	PMID:18593713
Biological Process	GO:0032925	regulation of activin receptor signaling pathway	SMAD7	IDA		Human	PMID:16720724
Biological Process	GO:0055117	regulation of cardiac muscle contraction	Smad7	IMP		Mouse	MGI:MGI:3836072|PMID:18952608
Biological Process	GO:0010717	regulation of epithelial to mesenchymal transition	SMAD7	IMP		Human	PMID:24887517
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	Smad7	IDA		Rat	PMID:11959632|RGD:625758
Biological Process	GO:0034616	response to laminar fluid shear stress	SMAD7	IEP		Human	PMID:9256479
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Smad7	IDA		Mouse	PMID:11557747
Biological Process	GO:0001657	ureteric bud development	Smad7	IEP		Mouse	MGI:MGI:3525982|PMID:14656760
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	Smad7	IMP		Mouse	MGI:MGI:3836072|PMID:18952608
Biological Process	GO:0060412	ventricular septum morphogenesis	Smad7	IMP		Mouse	MGI:MGI:3836072|PMID:18952608

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern