Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMC1A
  • Mouse genes Smc1a
  • Rat genes Smc1a
  • Zfish genes smc1a,smc1al
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smc1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	SMC1A	IDA		Human	PMID:11076961
Molecular Function	GO:0003682	chromatin binding	Smc1a	IDA		Mouse	PMID:20720539
Molecular Function	GO:0003682	chromatin binding	Smc1a	IDA		Mouse	PMID:22415368
Molecular Function	GO:0036033	mediator complex binding	Smc1a	IDA		Mouse	PMID:20720539
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q9DGN1	Human	PMID:11076961
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q14980	Human	PMID:11590136
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:P38398	Human	PMID:11877377
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q8WVB6	Human	PMID:12930902
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q9CPY3	Human	PMID:15837422
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:P09884	Human	PMID:16438930
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:P33993	Human	PMID:16438930
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:P35251	Human	PMID:16438930
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q14566	Human	PMID:16438930
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:O60216	Human	PMID:17112726
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q8N3U4	Human	PMID:17112726
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q9UQE7	Human	PMID:17112726
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:O60216	Human	PMID:17113138
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q8N3U4	Human	PMID:17113138
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q9UQE7	Human	PMID:17113138
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q9UQE7	Human	PMID:17349791
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:P78406	Human	PMID:18832153
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q9UQE7	Human	PMID:18832153
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q8N3U4	Human	PMID:19629043
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:O60216	Human	PMID:20818333
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q9UQE7	Human	PMID:22628566
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:O60216	Human	PMID:22885700
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q96FF9	Human	PMID:22885700
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q9UQE7	Human	PMID:22885700
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q6PJG6	Human	PMID:22977523
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:O60216	Human	PMID:23242214
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q5FBB7	Human	PMID:23242214
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q8N3U4	Human	PMID:23242214
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q96FF9	Human	PMID:23242214
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q9UQE7	Human	PMID:23242214
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q99IB8:PRO_0000045603	Human	PMID:24136289
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q8N3U4	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:O60216	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q8N3U4	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q96FF9	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q9UQE7	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:O60216	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q8N3U4	Human	PMID:29263825
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q8N3U4	Human	PMID:29867216
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q9UQE7	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q92915-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMC1A	IPI	UniProtKB:Q9UQE7	Human	PMID:9789013
Molecular Function	GO:0005515	protein binding	Smc1a	IPI	UniProtKB:Q6A078	Mouse	MGI:MGI:3624140|PMID:16632484
Molecular Function	GO:0005515	protein binding	Smc1a	IPI	UniProtKB:Q61550,UniProtKB:Q9CW03	Mouse	MGI:MGI:1340883|PMID:10375619
Molecular Function	GO:0005515	protein binding	Smc1a	IPI	UniProtKB:Q61687|UniProtKB:Q9Z2D6	Mouse	MGI:MGI:4439201|PMID:20159591
Molecular Function	GO:0046982	protein heterodimerization activity	SMC1A	IPI	UniProtKB:Q9UQE7	Human	PMID:11590136
Molecular Function	GO:0003723	RNA binding	SMC1A	HDA		Human	PMID:22681889
Cellular Component	GO:0008278	cohesin complex	SMC1A	IDA		Human	PMID:11590136
Cellular Component	GO:0008278	cohesin complex	SMC1A	IDA		Human	PMID:22628566
Cellular Component	GO:0008278	cohesin complex	SMC1A	IDA		Human	PMID:9789013
Cellular Component	GO:0008278	cohesin complex	Smc1a	IDA		Mouse	MGI:MGI:1340883|PMID:10375619
Cellular Component	GO:0005829	cytosol	SMC1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000776	kinetochore	SMC1A	IDA		Human	PMID:11682612
Cellular Component	GO:0000776	kinetochore	SMC1A	IDA		Human	PMID:12199140
Cellular Component	GO:0000800	lateral element	Smc1a	IDA		Rat	PMID:10652260|RGD:1331378
Cellular Component	GO:0030893	meiotic cohesin complex	SMC1A	IDA		Human	PMID:21242291
Cellular Component	GO:0030893	meiotic cohesin complex	Smc1a	IDA		Mouse	MGI:MGI:5050018|PMID:21527826
Cellular Component	GO:0097431	mitotic spindle pole	SMC1A	IDA		Human	PMID:11590136
Cellular Component	GO:0016363	nuclear matrix	SMC1A	IDA		Human	PMID:11590136
Cellular Component	GO:0005654	nucleoplasm	SMC1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	Smc1a	IDA		Rat	PMID:10652260|RGD:1331378
Cellular Component	GO:0005634	nucleus	SMC1A	IDA		Human	PMID:11076961
Cellular Component	GO:0005634	nucleus	Smc1a	IDA		Mouse	MGI:MGI:1340883|PMID:10375619
Cellular Component	GO:0005634	nucleus	Smc1a	IDA		Rat	PMID:10652260|RGD:1331378
Cellular Component	GO:0000795	synaptonemal complex	Smc1a	IDA		Rat	PMID:10652260|RGD:1331378
Biological Process	GO:0007417	central nervous system development	smc1a	IMP	ZFIN:ZDB-MRPHLNO-160407-5	Zfish	PMID:26206533
Biological Process	GO:0007417	central nervous system development	smc1a	IMP	ZFIN:ZDB-MRPHLNO-160407-4	Zfish	PMID:26206533
Biological Process	GO:0007417	central nervous system development	smc1a	IMP	ZFIN:ZDB-MRPHLNO-160407-3	Zfish	PMID:26206533
Biological Process	GO:0048589	developmental growth	smc1a	IGI	ZFIN:ZDB-MRPHLNO-131219-3,ZFIN:ZDB-MRPHLNO-160407-3	Zfish	PMID:26206533
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	smc1al	IMP	ZFIN:ZDB-GENO-040721-2	Zfish	PMID:25378554
Biological Process	GO:0051321	meiotic cell cycle	Smc1a	IPI	PR:P70281	Mouse	PMID:12759374
Biological Process	GO:0051321	meiotic cell cycle	Smc1a	IDA		Rat	PMID:10652260|RGD:1331378
Biological Process	GO:0051321	meiotic cell cycle	Smc1a	IEP		Rat	PMID:10652260|RGD:1331378
Biological Process	GO:0090307	mitotic spindle assembly	SMC1A	IMP		Human	PMID:11590136
Biological Process	GO:0072423	response to DNA damage checkpoint signaling	SMC1A	IDA		Human	PMID:11877377
Biological Process	GO:0009314	response to radiation	SMC1A	IEP		Human	PMID:11877377
Biological Process	GO:0007062	sister chromatid cohesion	SMC1A	IMP		Human	PMID:15917200
Biological Process	GO:0035019	somatic stem cell population maintenance	Smc1a	IMP		Mouse	PMID:20720539

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern