Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMC5
  • Mouse genes Smc5
  • Rat genes Smc5
  • Zfish genes smc5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smc5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000217	DNA secondary structure binding	SMC5	IDA		Human	PMID:28095508
Molecular Function	GO:0005515	protein binding	SMC5	IPI	UniProtKB:Q96SB8	Human	PMID:11408570
Molecular Function	GO:0005515	protein binding	SMC5	IPI	UniProtKB:Q96SB8	Human	PMID:15601840
Molecular Function	GO:0005515	protein binding	SMC5	IPI	UniProtKB:Q96SB8	Human	PMID:18086888
Molecular Function	GO:0005515	protein binding	SMC5	IPI	UniProtKB:Q8IX21	Human	PMID:25931565
Molecular Function	GO:0005515	protein binding	SMC5	IPI	UniProtKB:Q9NS91	Human	PMID:25931565
Molecular Function	GO:0005515	protein binding	SMC5	IPI	UniProtKB:Q96SB8	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	SMC5	IPI	UniProtKB:Q8N140	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SMC5	IPI	UniProtKB:Q9NRI5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMC5	IPI	UniProtKB:Q8IX21	Human	PMID:32389690
Molecular Function	GO:0005515	protein binding	SMC5	IPI	UniProtKB:Q8N140	Human	PMID:32389690
Molecular Function	GO:0005515	protein binding	SMC5	IPI	UniProtKB:Q96SB8	Human	PMID:32389690
Cellular Component	GO:0030054	cell junction	SMC5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000775	chromosome, centromeric region	Smc5	IDA		Mouse	PMID:26919979
Cellular Component	GO:0000781	chromosome, telomeric region	SMC5	IDA		Human	PMID:17589526
Cellular Component	GO:0000781	chromosome, telomeric region	Smc5	IMP		Mouse	MGI:MGI:5819345|PMID:19793919
Cellular Component	GO:0005737	cytoplasm	Smc5	IDA		Mouse	PMID:26919979
Cellular Component	GO:0035061	interchromatin granule	SMC5	IDA		Human	PMID:11408570
Cellular Component	GO:0016607	nuclear speck	SMC5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SMC5	IDA		Human	PMID:28095508
Cellular Component	GO:0005634	nucleus	SMC5	IDA		Human	PMID:11408570
Cellular Component	GO:0005634	nucleus	Smc5	IDA		Mouse	MGI:MGI:5437430|PMID:20339383
Cellular Component	GO:0005634	nucleus	Smc5	IDA		Mouse	PMID:26919979
Cellular Component	GO:0016605	PML body	SMC5	IDA		Human	PMID:17589526
Cellular Component	GO:0016605	PML body	Smc5	IMP		Mouse	MGI:MGI:5819345|PMID:19793919
Cellular Component	GO:0000803	sex chromosome	Smc5	IDA		Mouse	MGI:MGI:4818566|PMID:11408570
Cellular Component	GO:0035861	site of double-strand break	SMC5	IDA		Human	PMID:25931565
Cellular Component	GO:0030915	Smc5-Smc6 complex	SMC5	IDA		Human	PMID:18086888
Cellular Component	GO:0030915	Smc5-Smc6 complex	Smc5	IDA		Mouse	PMID:26919979
Biological Process	GO:0090398	cellular senescence	SMC5	IMP		Human	PMID:17589526
Biological Process	GO:0030261	chromosome condensation	Smc5	IMP	MGI:MGI:5882566	Mouse	PMID:26919979
Biological Process	GO:0007059	chromosome segregation	Smc5	IMP	MGI:MGI:5882566	Mouse	PMID:26919979
Biological Process	GO:0006974	DNA damage response	SMC5	IDA		Human	PMID:11408570
Biological Process	GO:0006974	DNA damage response	SMC5	IDA		Human	PMID:25931565
Biological Process	GO:0000724	double-strand break repair via homologous recombination	SMC5	IMP		Human	PMID:16810316
Biological Process	GO:0018393	internal peptidyl-lysine acetylation	Smc5	IMP	MGI:MGI:5882566	Mouse	PMID:26919979
Biological Process	GO:0044772	mitotic cell cycle phase transition	Smc5	IMP	MGI:MGI:5882566	Mouse	PMID:26919979
Biological Process	GO:0044828	negative regulation by host of viral genome replication	SMC5	IDA		Human	PMID:28095508
Biological Process	GO:0051984	positive regulation of chromosome segregation	SMC5	IMP		Human	PMID:25931565
Biological Process	GO:0034184	positive regulation of maintenance of mitotic sister chromatid cohesion	SMC5	IMP		Human	PMID:19502785
Biological Process	GO:0071459	protein localization to chromosome, centromeric region	Smc5	IMP	MGI:MGI:5882566	Mouse	PMID:26919979
Biological Process	GO:0019827	stem cell population maintenance	Smc5	IMP	MGI:MGI:5882566	Mouse	PMID:26919979
Biological Process	GO:0000722	telomere maintenance via recombination	SMC5	IMP		Human	PMID:17589526

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern