Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMCR8
  • Mouse genes Smcr8
  • Rat genes Smcr8
  • Zfish genes smcr8a,smcr8b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smcr8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	SMCR8	IDA		Human	PMID:27103069
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	SMCR8	IDA		Human	PMID:27617292
Molecular Function	GO:0005515	protein binding	SMCR8	IPI	UniProtKB:P11142	Human	PMID:27103069
Molecular Function	GO:0005515	protein binding	SMCR8	IPI	UniProtKB:Q96LT7	Human	PMID:27103069
Molecular Function	GO:0005515	protein binding	SMCR8	IPI	UniProtKB:Q96LT7-1	Human	PMID:27103069
Molecular Function	GO:0005515	protein binding	SMCR8	IPI	UniProtKB:Q96LT7	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	SMCR8	IPI	UniProtKB:Q96LT7	Human	PMID:27559131
Molecular Function	GO:0005515	protein binding	SMCR8	IPI	UniProtKB:O75143	Human	PMID:28195531
Molecular Function	GO:0005515	protein binding	SMCR8	IPI	UniProtKB:O75385	Human	PMID:28195531
Molecular Function	GO:0005515	protein binding	SMCR8	IPI	UniProtKB:Q96LT7	Human	PMID:28195531
Molecular Function	GO:0005515	protein binding	SMCR8	IPI	UniProtKB:Q9HAD4	Human	PMID:28195531
Molecular Function	GO:0005515	protein binding	SMCR8	IPI	UniProtKB:Q96LT7-1	Human	PMID:29950492
Molecular Function	GO:0005515	protein binding	SMCR8	IPI	UniProtKB:Q96LT7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMCR8	IPI	UniProtKB:Q96LT7,UniProtKB:Q9HAD4	Human	PMID:32303654
Molecular Function	GO:0005515	protein binding	Smcr8	IPI	UniProtKB:Q6DFW0	Mouse	MGI:MGI:5811684|PMID:27875531
Molecular Function	GO:0005515	protein binding	Smcr8	IPI	UniProtKB:Q62108	Mouse	MGI:MGI:6451238|PMID:31651360
Molecular Function	GO:0019901	protein kinase binding	SMCR8	IPI	UniProtKB:Q9UHD2	Human	PMID:27103069
Molecular Function	GO:0004860	protein kinase inhibitor activity	SMCR8	IMP		Human	PMID:28195531
Cellular Component	GO:1990316	Atg1/ULK1 kinase complex	SMCR8	IDA		Human	PMID:28195531
Cellular Component	GO:0000785	chromatin	SMCR8	IDA		Human	PMID:28195531
Cellular Component	GO:0005737	cytoplasm	SMCR8	IDA		Human	PMID:27193190
Cellular Component	GO:0005737	cytoplasm	SMCR8	IDA		Human	PMID:28195531
Cellular Component	GO:0005737	cytoplasm	Smcr8	IDA		Mouse	MGI:MGI:5810480|PMID:27617292
Cellular Component	GO:0032045	guanyl-nucleotide exchange factor complex	SMCR8	IPI		Human	PMID:29950492
Cellular Component	GO:0032045	guanyl-nucleotide exchange factor complex	SMCR8	IDA		Human	PMID:27103069
Cellular Component	GO:0005654	nucleoplasm	SMCR8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SMCR8	IDA		Human	PMID:28195531
Cellular Component	GO:0098794	postsynapse	Smcr8	IDA		Mouse	MGI:MGI:6451238|PMID:31651360
Cellular Component	GO:0098793	presynapse	Smcr8	IDA		Mouse	MGI:MGI:6451238|PMID:31651360
Biological Process	GO:1902902	negative regulation of autophagosome assembly	SMCR8	IMP		Human	PMID:28195531
Biological Process	GO:0010629	negative regulation of gene expression	SMCR8	IMP		Human	PMID:28195531
Biological Process	GO:0016242	negative regulation of macroautophagy	SMCR8	IMP		Human	PMID:28195531
Biological Process	GO:0006469	negative regulation of protein kinase activity	SMCR8	IMP		Human	PMID:28195531
Biological Process	GO:1901098	positive regulation of autophagosome maturation	SMCR8	IMP		Human	PMID:28195531
Biological Process	GO:0043547	positive regulation of GTPase activity	SMCR8	IMP		Human	PMID:32303654
Biological Process	GO:0032008	positive regulation of TOR signaling	SMCR8	IMP		Human	PMID:28195531
Biological Process	GO:0010506	regulation of autophagy	SMCR8	IMP		Human	PMID:27103069
Biological Process	GO:0010506	regulation of autophagy	Smcr8	IMP		Mouse	MGI:MGI:5810480|PMID:27617292
Biological Process	GO:1903432	regulation of TORC1 signaling	SMCR8	IMP		Human	PMID:27559131

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern