Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMG6
  • Mouse genes Smg6
  • Rat genes Smg6
  • Zfish genes smg6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smg6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070182	DNA polymerase binding	SMG6	IPI	UniProtKB:O14746	Human	PMID:17940095
Molecular Function	GO:0070182	DNA polymerase binding	SMG6	IPI	UniProtKB:O14746	Human	PMID:22011238
Molecular Function	GO:0005515	protein binding	SMG6	IPI	UniProtKB:O14746	Human	PMID:12699629
Molecular Function	GO:0005515	protein binding	SMG6	IPI	UniProtKB:Q92540	Human	PMID:20930030
Molecular Function	GO:0005515	protein binding	SMG6	IPI	UniProtKB:Q92900	Human	PMID:20930030
Molecular Function	GO:0005515	protein binding	SMG6	IPI	UniProtKB:Q9BZI7	Human	PMID:20930030
Molecular Function	GO:0005515	protein binding	SMG6	IPI	UniProtKB:Q9HAU5	Human	PMID:20930030
Molecular Function	GO:0005515	protein binding	SMG6	IPI	UniProtKB:Q9UPR3	Human	PMID:20930030
Molecular Function	GO:0005515	protein binding	SMG6	IPI	UniProtKB:Q92900-2	Human	PMID:21145460
Molecular Function	GO:0005515	protein binding	SMG6	IPI	UniProtKB:Q14147	Human	PMID:25220460
Molecular Function	GO:0005515	protein binding	SMG6	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMG6	IPI	UniProtKB:O00291	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SMG6	IPI	UniProtKB:O75400-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SMG6	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SMG6	IPI	UniProtKB:P55212	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SMG6	IPI	UniProtKB:P62826	Human	PMID:32814053
Molecular Function	GO:0043021	ribonucleoprotein complex binding	SMG6	IPI	ComplexPortal:CPX-17	Human	PMID:12676087
Molecular Function	GO:0043021	ribonucleoprotein complex binding	SMG6	IPI	ComplexPortal:CPX-17	Human	PMID:17940095
Molecular Function	GO:0003723	RNA binding	SMG6	IPI	RNAcentral:URS00004416C5_9606	Human	PMID:17940095
Molecular Function	GO:0004521	RNA endonuclease activity	SMG6	IMP		Human	PMID:18974281
Molecular Function	GO:0004521	RNA endonuclease activity	SMG6	IDA		Human	PMID:19060897
Molecular Function	GO:0070034	telomerase RNA binding	SMG6	IPI	RNAcentral:URS00004416C5_9606	Human	PMID:15857955
Molecular Function	GO:0070034	telomerase RNA binding	SMG6	IPI	RNAcentral:URS00004A7003_9606	Human	PMID:15857955
Molecular Function	GO:0070034	telomerase RNA binding	SMG6	IPI	RNAcentral:URS00004A7003_9606	Human	PMID:17940095
Molecular Function	GO:0042162	telomeric DNA binding	SMG6	IDA		Human	PMID:12699629
Molecular Function	GO:0042162	telomeric DNA binding	SMG6	IDA		Human	PMID:17916692
Cellular Component	GO:0005737	cytoplasm	SMG6	IDA		Human	PMID:14636577
Cellular Component	GO:0005829	cytosol	SMG6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	SMG6	IDA		Human	PMID:19060897
Cellular Component	GO:0005730	nucleolus	SMG6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	SMG6	IDA		Human	PMID:12676087
Cellular Component	GO:0005634	nucleus	SMG6	IDA		Human	PMID:14636577
Biological Process	GO:0043009	chordate embryonic development	smg6	IMP	ZFIN:ZDB-MRPHLNO-090715-6	Zfish	PMID:19414594
Biological Process	GO:1904354	negative regulation of telomere capping	SMG6	IDA		Human	PMID:12676087
Biological Process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	SMG6	IMP		Human	PMID:18974281
Biological Process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	SMG6	IMP		Human	PMID:19060897
Biological Process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	SMG6	IMP		Human	PMID:20930030
Biological Process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	smg6	IDA		Zfish	PMID:19414594
Biological Process	GO:0032204	regulation of telomere maintenance	SMG6	IMP		Human	PMID:12699629
Biological Process	GO:0032204	regulation of telomere maintenance	SMG6	IMP		Human	PMID:17916692

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern