Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMPD2
  • Mouse genes Smpd2
  • Rat genes Smpd2
  • Zfish genes smpd2a,smpd2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smpd2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	SMPD2	IDA		Human	PMID:10608884
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	SMPD2	IDA		Human	PMID:14741383
Molecular Function	GO:0005515	protein binding	SMPD2	IPI	UniProtKB:O00622	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMPD2	IPI	UniProtKB:O15173	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMPD2	IPI	UniProtKB:P49675	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMPD2	IPI	UniProtKB:P53367	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMPD2	IPI	UniProtKB:Q05329	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMPD2	IPI	UniProtKB:Q14973	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMPD2	IPI	UniProtKB:Q8NI60	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMPD2	IPI	UniProtKB:Q96AL5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMPD2	IPI	UniProtKB:Q9NRX6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMPD2	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMPD2	IPI	UniProtKB:Q9UHI5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMPD2	IPI	UniProtKB:Q9UKF7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMPD2	IPI	UniProtKB:Q9ULP0-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMPD2	IPI	UniProtKB:Q9Y371	Human	PMID:32814053
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	SMPD2	IDA		Human	PMID:10608884
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	SMPD2	IDA		Human	PMID:14741383
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	Smpd2	IDA		Mouse	MGI:MGI:1202145|PMID:9520418
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	Smpd2	IMP	MGI:MGI:2183203	Mouse	PMID:15764706
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	Smpd2	IDA		Rat	PMID:10832103|RGD:634108
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	smpd2a	IMP	ZFIN:ZDB-MRPHLNO-090121-4	Zfish	PMID:18678863
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	smpd2a	IMP	ZFIN:ZDB-MRPHLNO-051014-1	Zfish	PMID:15741222
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	smpd2a	IDA		Zfish	PMID:18678863
Cellular Component	GO:0005901	caveola	Smpd2	IDA		Rat	PMID:12473648|RGD:1581395
Cellular Component	GO:0005794	Golgi apparatus	smpd2a	IDA		Zfish	PMID:18678863
Cellular Component	GO:0016020	membrane	Smpd2	IDA		Rat	PMID:12473648|RGD:1581395
Cellular Component	GO:0005886	plasma membrane	Smpd2	IDA		Mouse	MGI:MGI:1202145|PMID:9520418
Biological Process	GO:0071502	cellular response to temperature stimulus	smpd2a	IDA		Zfish	PMID:25168245
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	smpd2a	IMP	ZFIN:ZDB-MRPHLNO-051014-1	Zfish	PMID:15741222
Biological Process	GO:0046513	ceramide biosynthetic process	Smpd2	IDA		Rat	PMID:12473648|RGD:1581395
Biological Process	GO:0046513	ceramide biosynthetic process	smpd2a	IMP	ZFIN:ZDB-MRPHLNO-090121-4	Zfish	PMID:18678863
Biological Process	GO:0035556	intracellular signal transduction	Smpd2	IMP		Rat	PMID:12473648|RGD:1581395
Biological Process	GO:0000165	MAPK cascade	smpd2a	IDA		Zfish	PMID:25168245
Biological Process	GO:0009612	response to mechanical stimulus	Smpd2	IMP		Rat	PMID:12473648|RGD:1581395
Biological Process	GO:0090520	sphingolipid mediated signaling pathway	smpd2a	IDA		Zfish	PMID:25168245
Biological Process	GO:0006685	sphingomyelin catabolic process	SMPD2	IDA		Human	PMID:10608884
Biological Process	GO:0006685	sphingomyelin catabolic process	SMPD2	IDA		Human	PMID:14741383
Biological Process	GO:0006685	sphingomyelin catabolic process	Smpd2	IDA		Mouse	MGI:MGI:1202145|PMID:9520418
Biological Process	GO:0006685	sphingomyelin catabolic process	Smpd2	IMP		Mouse	PMID:23973266
Biological Process	GO:0006684	sphingomyelin metabolic process	smpd2a	IMP	ZFIN:ZDB-MRPHLNO-090121-4	Zfish	PMID:18678863

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern