Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMPD3
  • Mouse genes Smpd3
  • Rat genes Smpd3
  • Zfish genes smpd3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smpd3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Smpd3	IPI	PR:Q9JJY3	Mouse	PMID:25287744
Molecular Function	GO:0061751	neutral sphingomyelin phosphodiesterase activity	Smpd3	IDA		Mouse	PMID:23973266
Molecular Function	GO:0061751	neutral sphingomyelin phosphodiesterase activity	Smpd3	IDA		Mouse	PMID:25287744
Molecular Function	GO:0061751	neutral sphingomyelin phosphodiesterase activity	Smpd3	IDA		Mouse	PMID:16025116
Molecular Function	GO:0061751	neutral sphingomyelin phosphodiesterase activity	Smpd3	IDA		Mouse	PMID:23046545
Molecular Function	GO:0070300	phosphatidic acid binding	Smpd3	IDA		Mouse	MGI:MGI:6450311|PMID:21550973
Molecular Function	GO:0001786	phosphatidylserine binding	Smpd3	IDA		Mouse	MGI:MGI:6450311|PMID:21550973
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	SMPD3	IDA		Human	PMID:14741383
Molecular Function	GO:0005515	protein binding	SMPD3	IPI	UniProtKB:O75530	Human	PMID:20080539
Molecular Function	GO:0005515	protein binding	Smpd3	IPI	UniProtKB:O75530	Mouse	MGI:MGI:5919033|PMID:20080539
Molecular Function	GO:0005515	protein binding	Smpd3	IPI	UniProtKB:P10809	Mouse	MGI:MGI:5613460|PMID:23840630
Molecular Function	GO:0005515	protein binding	Smpd3	IPI	RGD:1309782	Rat	PMID:24007266|RGD:9588303
Molecular Function	GO:0005515	protein binding	Smpd3	IPI	RGD:69229	Rat	PMID:24007266|RGD:9588303
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	SMPD3	IDA		Human	PMID:14741383
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	Smpd3	IDA		Mouse	MGI:MGI:6450311|PMID:21550973
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	Smpd3	IMP	MGI:MGI:3575405	Mouse	PMID:15764706
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	Smpd3	IDA		Mouse	PMID:10823942
Cellular Component	GO:0005737	cytoplasm	Smpd3	IDA		Rat	PMID:9218439|RGD:634110
Cellular Component	GO:0005794	Golgi apparatus	Smpd3	IDA		Mouse	PMID:10823942
Cellular Component	GO:0000137	Golgi cis cisterna	Smpd3	IDA		Mouse	PMID:15764706
Cellular Component	GO:0016020	membrane	Smpd3	IDA		Rat	PMID:16140422|RGD:10042973
Cellular Component	GO:0005886	plasma membrane	Smpd3	IDA		Mouse	MGI:MGI:6450311|PMID:21550973
Cellular Component	GO:0005886	plasma membrane	Smpd3	IDA		Mouse	PMID:25287744
Biological Process	GO:0007568	aging	Smpd3	IEP		Rat	PMID:17693623|RGD:10042964
Biological Process	GO:0014824	artery smooth muscle contraction	Smpd3	IMP		Rat	PMID:19088082|RGD:10042965
Biological Process	GO:0030509	BMP signaling pathway	Smpd3	IDA		Mouse	PMID:24505141
Biological Process	GO:0060348	bone development	Smpd3	IMP		Mouse	PMID:27325675
Biological Process	GO:0098868	bone growth	Smpd3	IMP		Mouse	PMID:24585429
Biological Process	GO:0098868	bone growth	Smpd3	IMP	MGI:MGI:3575405	Mouse	PMID:17626887
Biological Process	GO:0030282	bone mineralization	Smpd3	IDA		Mouse	PMID:21788370
Biological Process	GO:0030282	bone mineralization	Smpd3	IMP		Mouse	PMID:24585429
Biological Process	GO:0030282	bone mineralization	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:21788370
Biological Process	GO:0051216	cartilage development	Smpd3	IMP	MGI:MGI:3575405	Mouse	PMID:17591962
Biological Process	GO:0051216	cartilage development	Smpd3	IDA		Mouse	PMID:27325675
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Smpd3	IDA		Mouse	PMID:23651497
Biological Process	GO:0071347	cellular response to interleukin-1	Smpd3	IEP		Rat	PMID:17693623|RGD:10042964
Biological Process	GO:0071286	cellular response to magnesium ion	Smpd3	IDA		Mouse	PMID:23973266
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:20352118
Biological Process	GO:1901653	cellular response to peptide	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:27325675
Biological Process	GO:0034614	cellular response to reactive oxygen species	Smpd3	IMP		Mouse	PMID:17561096
Biological Process	GO:0071461	cellular response to redox state	Smpd3	IMP		Mouse	PMID:25287744
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:16025116
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:20352118
Biological Process	GO:0006672	ceramide metabolic process	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:22383528
Biological Process	GO:0006672	ceramide metabolic process	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:23046545
Biological Process	GO:0061300	cerebellum vasculature development	smpd3	IMP	ZFIN:ZDB-MRPHLNO-170824-5	Zfish	PMID:28429770
Biological Process	GO:0002063	chondrocyte development	Smpd3	IMP	MGI:MGI:3575405	Mouse	PMID:17591962
Biological Process	GO:0002063	chondrocyte development	Smpd3	IMP		Mouse	PMID:24505141
Biological Process	GO:0003433	chondrocyte development involved in endochondral bone morphogenesis	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:21788370
Biological Process	GO:0032963	collagen metabolic process	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:22910579
Biological Process	GO:0097187	dentinogenesis	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:16025116
Biological Process	GO:0071897	DNA biosynthetic process	Smpd3	IMP		Mouse	PMID:23651497
Biological Process	GO:0090494	dopamine uptake	Smpd3	IMP		Rat	PMID:20096352|RGD:10041064
Biological Process	GO:0001958	endochondral ossification	Smpd3	IMP		Mouse	PMID:24505141
Biological Process	GO:0001958	endochondral ossification	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:21788370
Biological Process	GO:0001958	endochondral ossification	Smpd3	IMP	MGI:MGI:3575405	Mouse	PMID:17591962
Biological Process	GO:0085029	extracellular matrix assembly	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:22910579
Biological Process	GO:0070314	G1 to G0 transition	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:23046545
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Smpd3	IMP		Mouse	PMID:24029230
Biological Process	GO:0048286	lung alveolus development	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:22945695
Biological Process	GO:0030324	lung development	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:22945695
Biological Process	GO:0140014	mitotic nuclear division	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:20352118
Biological Process	GO:0035264	multicellular organism growth	Smpd3	IMP		Mouse	PMID:24585429
Biological Process	GO:0035264	multicellular organism growth	Smpd3	IDA		Mouse	PMID:24585429
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	Smpd3	IMP		Rat	PMID:20096352|RGD:10041064
Biological Process	GO:1900126	negative regulation of hyaluronan biosynthetic process	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:22383528
Biological Process	GO:0001503	ossification	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:16025116
Biological Process	GO:0001503	ossification	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:22910579
Biological Process	GO:0030072	peptide hormone secretion	Smpd3	IMP	MGI:MGI:3575405	Mouse	PMID:15764706
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	Smpd3	IMP		Mouse	PMID:23651497
Biological Process	GO:0015774	polysaccharide transport	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:22383528
Biological Process	GO:2000304	positive regulation of ceramide biosynthetic process	Smpd3	IMP		Rat	PMID:20096352|RGD:10041064
Biological Process	GO:1903543	positive regulation of exosomal secretion	Smpd3	IMP		Rat	PMID:24743145|RGD:10054083
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	Smpd3	IGI	MGI:MGI:1316649	Mouse	PMID:23651497
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Smpd3	IMP		Rat	PMID:14720208|RGD:10042970
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Smpd3	IMP		Rat	PMID:14720208|RGD:10042970
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Smpd3	IMP		Mouse	PMID:17561096
Biological Process	GO:0043491	protein kinase B signaling	Smpd3	IMP		Mouse	PMID:24505141
Biological Process	GO:0061035	regulation of cartilage development	Smpd3	IMP		Mouse	PMID:24505141
Biological Process	GO:1900125	regulation of hyaluronan biosynthetic process	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:22383528
Biological Process	GO:0002685	regulation of leukocyte migration	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:28377412
Biological Process	GO:0001932	regulation of protein phosphorylation	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:22383528
Biological Process	GO:0060541	respiratory system development	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:22945695
Biological Process	GO:0007165	signal transduction	Smpd3	IMP		Mouse	PMID:17561096
Biological Process	GO:0001501	skeletal system development	Smpd3	IMP	MGI:MGI:3575405	Mouse	PMID:17591962
Biological Process	GO:0001501	skeletal system development	Smpd3	IDA		Mouse	PMID:24585429
Biological Process	GO:0001501	skeletal system development	Smpd3	IMP		Mouse	PMID:24585429
Biological Process	GO:0090520	sphingolipid mediated signaling pathway	Smpd3	IDA		Mouse	PMID:23651497
Biological Process	GO:0006665	sphingolipid metabolic process	Smpd3	IMP	MGI:MGI:1856877	Mouse	PMID:22945695
Biological Process	GO:0006685	sphingomyelin catabolic process	SMPD3	IDA		Human	PMID:14741383
Biological Process	GO:0006685	sphingomyelin catabolic process	Smpd3	IMP		Mouse	PMID:23973266
Biological Process	GO:0006684	sphingomyelin metabolic process	Smpd3	IDA		Mouse	MGI:MGI:6450311|PMID:21550973
Biological Process	GO:0006684	sphingomyelin metabolic process	Smpd3	IDA		Mouse	PMID:10823942

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern