Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMPD4
  • Mouse genes Smpd4
  • Rat genes Smpd4
  • Zfish genes smpd4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smpd4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	Smpd4	IDA		Mouse	MGI:MGI:6450503|PMID:25180167
Molecular Function	GO:0050290	sphingomyelin phosphodiesterase D activity	SMPD4	IDA		Human	PMID:16517606
Molecular Function	GO:0050290	sphingomyelin phosphodiesterase D activity	SMPD4	IDA		Human	PMID:25180167
Cellular Component	GO:0005783	endoplasmic reticulum	SMPD4	IDA		Human	PMID:16517606
Cellular Component	GO:0005783	endoplasmic reticulum	SMPD4	IDA		Human	PMID:18505924
Cellular Component	GO:0005783	endoplasmic reticulum	SMPD4	IDA		Human	PMID:31495489
Cellular Component	GO:0005783	endoplasmic reticulum	Smpd4	IDA		Mouse	MGI:MGI:6450503|PMID:25180167
Cellular Component	GO:0005794	Golgi apparatus	SMPD4	IDA		Human	PMID:16517606
Cellular Component	GO:0005635	nuclear envelope	Smpd4	IDA		Mouse	MGI:MGI:6316504|PMID:31142202
Cellular Component	GO:0005640	nuclear outer membrane	SMPD4	IDA		Human	PMID:31495489
Cellular Component	GO:0042383	sarcolemma	Smpd4	IDA		Mouse	MGI:MGI:6450503|PMID:25180167
Cellular Component	GO:0005802	trans-Golgi network	SMPD4	IDA		Human	PMID:16517606
Biological Process	GO:0071356	cellular response to tumor necrosis factor	SMPD4	IDA		Human	PMID:16517606
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Smpd4	IDA		Mouse	MGI:MGI:6450503|PMID:25180167
Biological Process	GO:0046513	ceramide biosynthetic process	SMPD4	IDA		Human	PMID:16517606
Biological Process	GO:0046513	ceramide biosynthetic process	SMPD4	IDA		Human	PMID:25180167
Biological Process	GO:0046513	ceramide biosynthetic process	Smpd4	IDA		Mouse	MGI:MGI:6450503|PMID:25180167
Biological Process	GO:0007029	endoplasmic reticulum organization	SMPD4	IMP		Human	PMID:31495489
Biological Process	GO:0046475	glycerophospholipid catabolic process	SMPD4	IDA		Human	PMID:16517606
Biological Process	GO:0001701	in utero embryonic development	Smpd4	IMP	MGI:MGI:5548688	Mouse	PMID:27996060
Biological Process	GO:0006685	sphingomyelin catabolic process	SMPD4	IDA		Human	PMID:16517606
Biological Process	GO:0006685	sphingomyelin catabolic process	SMPD4	IDA		Human	PMID:25180167
Biological Process	GO:0006685	sphingomyelin catabolic process	Smpd4	IDA		Mouse	MGI:MGI:6450503|PMID:25180167

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern