Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMURF1
  • Mouse genes Smurf1
  • Rat genes Smurf1
  • Zfish genes smurf1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smurf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070411	I-SMAD binding	SMURF1	IPI	UniProtKB:O43541	Human	PMID:11278251
Molecular Function	GO:0070411	I-SMAD binding	SMURF1	IPI	UniProtKB:O15105	Human	PMID:12151385
Molecular Function	GO:0005515	protein binding	SMURF1	IPI	UniProtKB:Q15797	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SMURF1	IPI	UniProtKB:Q15797	Human	PMID:19914168
Molecular Function	GO:0005515	protein binding	SMURF1	IPI	UniProtKB:Q9BUZ4	Human	PMID:19937093
Molecular Function	GO:0005515	protein binding	SMURF1	IPI	UniProtKB:P61289	Human	PMID:20580715
Molecular Function	GO:0005515	protein binding	SMURF1	IPI	UniProtKB:Q53GL0	Human	PMID:20580715
Molecular Function	GO:0005515	protein binding	SMURF1	IPI	UniProtKB:Q9Y5W3	Human	PMID:21382345
Molecular Function	GO:0005515	protein binding	SMURF1	IPI	UniProtKB:Q9H469	Human	PMID:21572392
Molecular Function	GO:0005515	protein binding	SMURF1	IPI	UniProtKB:P03316	Human	PMID:22020285
Molecular Function	GO:0005515	protein binding	SMURF1	IPI	UniProtKB:Q53GL0	Human	PMID:23032291
Molecular Function	GO:0005515	protein binding	Smurf1	IPI	UniProtKB:P03316	Mouse	MGI:MGI:5298125|PMID:22020285
Molecular Function	GO:0005515	protein binding	Smurf1	IPI	RGD:1303272	Rat	PMID:17728459|RGD:2302549
Molecular Function	GO:0070412	R-SMAD binding	SMURF1	IPI	UniProtKB:P84022	Human	PMID:11278251
Molecular Function	GO:0070412	R-SMAD binding	SMURF1	IPI	UniProtKB:Q15797	Human	PMID:11278251
Molecular Function	GO:0070412	R-SMAD binding	SMURF1	IPI	UniProtKB:Q99717	Human	PMID:11278251
Molecular Function	GO:0061630	ubiquitin protein ligase activity	SMURF1	IDA		Human	PMID:11278251
Molecular Function	GO:0061630	ubiquitin protein ligase activity	SMURF1	IDA		Human	PMID:12151385
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	SMURF1	IDA		Human	PMID:10458166
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	SMURF1	IDA		Human	PMID:19937093
Cellular Component	GO:0030424	axon	Smurf1	IDA		Rat	PMID:17728459|RGD:2302549
Cellular Component	GO:0005737	cytoplasm	SMURF1	IDA		Human	PMID:11278251
Cellular Component	GO:0005737	cytoplasm	SMURF1	IDA		Human	PMID:12151385
Cellular Component	GO:0005737	cytoplasm	SMURF1	IDA		Human	PMID:21572392
Cellular Component	GO:0070062	extracellular exosome	SMURF1	HDA		Human	PMID:19056867
Cellular Component	GO:0005739	mitochondrion	SMURF1	IGI	UniProtKB:Q9CUN6	Human	PMID:22020285
Cellular Component	GO:0043025	neuronal cell body	Smurf1	IDA		Rat	PMID:17728459|RGD:2302549
Cellular Component	GO:0005886	plasma membrane	SMURF1	IDA		Human	PMID:12151385
Biological Process	GO:0030509	BMP signaling pathway	SMURF1	IDA		Human	PMID:21572392
Biological Process	GO:0030154	cell differentiation	SMURF1	IDA		Human	PMID:10458166
Biological Process	GO:0061736	engulfment of target by autophagosome	SMURF1	IMP		Human	PMID:22020285
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	SMURF1	IDA		Human	PMID:27214554
Biological Process	GO:0030279	negative regulation of ossification	Smurf1	IMP	MGI:MGI:3576775	Mouse	PMID:15820682
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	SMURF1	IDA		Human	PMID:11278251
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	SMURF1	IDA		Human	PMID:12151385
Biological Process	GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	Smurf1	IMP		Mouse	MGI:MGI:5298125|PMID:22020285
Biological Process	GO:0045773	positive regulation of axon extension	Smurf1	IMP		Rat	PMID:23226367|RGD:151665335
Biological Process	GO:1903861	positive regulation of dendrite extension	SMURF1	IDA		Human	PMID:23999003
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	SMURF1	IMP		Human	PMID:21454619
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	SMURF1	IDA		Human	PMID:11278251
Biological Process	GO:0006611	protein export from nucleus	SMURF1	IDA		Human	PMID:11278251
Biological Process	GO:0034394	protein localization to cell surface	SMURF1	IDA		Human	PMID:12151385
Biological Process	GO:0000209	protein polyubiquitination	SMURF1	IDA		Human	PMID:19937093
Biological Process	GO:0071211	protein targeting to vacuole involved in autophagy	SMURF1	IMP		Human	PMID:22020285
Biological Process	GO:0016567	protein ubiquitination	SMURF1	IDA		Human	PMID:11278251
Biological Process	GO:0016567	protein ubiquitination	Smurf1	IMP	MGI:MGI:3576775	Mouse	PMID:15820682
Biological Process	GO:0032801	receptor catabolic process	SMURF1	IDA		Human	PMID:12151385
Biological Process	GO:0061753	substrate localization to autophagosome	SMURF1	IMP		Human	PMID:22020285
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	SMURF1	IDA		Human	PMID:10458166
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	SMURF1	IDA		Human	PMID:12151385
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	SMURF1	IDA		Human	PMID:19937093
Biological Process	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	SMURF1	IDA		Human	PMID:11278251
Biological Process	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	SMURF1	IDA		Human	PMID:12151385

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern