Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMURF2
  • Mouse genes Smurf2
  • Rat genes Smurf2
  • Zfish genes smurf2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smurf2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	SMURF2	IPI	UniProtKB:Q9HAU4	Human	PMID:15231748
Molecular Function	GO:0042802	identical protein binding	SMURF2	IPI	UniProtKB:Q9HAU4	Human	PMID:17719543
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:P0CG47	Human	PMID:14755250
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:Q9Y3C5	Human	PMID:14755250
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:O15105	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:Q15796	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:Q15797	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:Q9Y3C5	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:P0CG47	Human	PMID:17719543
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:P84022	Human	PMID:18729074
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:Q15796	Human	PMID:18729074
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:Q9WMX2:PRO_0000037548	Human	PMID:18985028
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:Q9Y3C5	Human	PMID:20676133
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:O15105	Human	PMID:20937913
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:Q15796	Human	PMID:20937913
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:Q15797	Human	PMID:20937913
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:Q9H469	Human	PMID:21572392
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:P84022	Human	PMID:22045334
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:Q15796	Human	PMID:22045334
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:O15105	Human	PMID:22921829
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:P46934-4	Human	PMID:25438670
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:P46934-4	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:Q15797	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:P53804	Human	PMID:30696809
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:P84022	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:Q15797	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:Q8WWV3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:P35260	Human	PMID:33673144
Molecular Function	GO:0005515	protein binding	SMURF2	IPI	UniProtKB:Q05128	Human	PMID:33673144
Molecular Function	GO:0005515	protein binding	Smurf2	IPI	UniProtKB:O14641	Mouse	MGI:MGI:3846247|PMID:19379695
Molecular Function	GO:0046332	SMAD binding	SMURF2	IPI	UniProtKB:P84022	Human	PMID:19122240
Molecular Function	GO:0046332	SMAD binding	SMURF2	IPI	UniProtKB:Q15796	Human	PMID:19122240
Molecular Function	GO:0046332	SMAD binding	Smurf2	IPI	RGD:69314	Rat	PMID:17347560|RGD:2302562
Molecular Function	GO:0005160	transforming growth factor beta receptor binding	Smurf2	IPI	RGD:3852	Rat	PMID:17347560|RGD:2302562
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	SMURF2	IDA		Human	PMID:14755250
Cellular Component	GO:0016607	nuclear speck	SMURF2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000151	ubiquitin ligase complex	SMURF2	IDA		Human	PMID:14755250
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	SMURF2	IDA		Human	PMID:19255252
Biological Process	GO:1901165	positive regulation of trophoblast cell migration	SMURF2	IDA		Human	PMID:19255252
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	SMURF2	IDA		Human	PMID:14755250
Biological Process	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	SMURF2	IDA		Human	PMID:19122240

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern