Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SMYD3
  • Mouse genes Smyd3
  • Rat genes
  • Zfish genes smyd3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Smyd3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140954	histone H3K36 dimethyltransferase activity	Smyd3	IDA		Mouse	MGI:MGI:4943402|PMID:16805913
Molecular Function	GO:0140939	histone H4 methyltransferase activity	SMYD3	IMP		Human	PMID:25738358
Molecular Function	GO:0005515	protein binding	SMYD3	IPI	UniProtKB:P07900	Human	PMID:25738358
Molecular Function	GO:0005515	protein binding	SMYD3	IPI	UniProtKB:Q13064	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMYD3	IPI	UniProtKB:Q15915	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMYD3	IPI	UniProtKB:Q16512	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMYD3	IPI	UniProtKB:Q7Z3B4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMYD3	IPI	UniProtKB:Q92529	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMYD3	IPI	UniProtKB:Q9H0I2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SMYD3	IPI	UniProtKB:Q9H0L4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Smyd3	IPI	UniProtKB:O60885	Mouse	PMID:23752591
Molecular Function	GO:0005515	protein binding	Smyd3	IPI	PR:Q9ESU6	Mouse	PMID:23752591
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Smyd3	IDA		Mouse	PMID:23752591
Molecular Function	GO:0000993	RNA polymerase II complex binding	Smyd3	IDA		Mouse	PMID:23752591
Molecular Function	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	Smyd3	IDA		Mouse	PMID:23752591
Cellular Component	GO:0005829	cytosol	SMYD3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SMYD3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SMYD3	IDA		Human	PMID:25738358
Cellular Component	GO:0005634	nucleus	Smyd3	IDA		Mouse	PMID:23752591
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Smyd3	IDA		Mouse	PMID:23752591
Biological Process	GO:0045184	establishment of protein localization	Smyd3	IMP		Mouse	PMID:23752591
Biological Process	GO:0007507	heart development	smyd3	IMP	ZFIN:ZDB-MRPHLNO-110922-1	Zfish	PMID:21887258
Biological Process	GO:0007507	heart development	smyd3	IMP	ZFIN:ZDB-MRPHLNO-110922-2	Zfish	PMID:21887258
Biological Process	GO:0003007	heart morphogenesis	smyd3	IMP	ZFIN:ZDB-MRPHLNO-151013-5	Zfish	PMID:25997738
Biological Process	GO:0003007	heart morphogenesis	smyd3	IGI	ZFIN:ZDB-MRPHLNO-151013-5,ZFIN:ZDB-MRPHLNO-151013-6	Zfish	PMID:25997738
Biological Process	GO:0014904	myotube cell development	Smyd3	IMP		Mouse	PMID:23752591
Biological Process	GO:0006469	negative regulation of protein kinase activity	Smyd3	IMP		Mouse	PMID:23752591
Biological Process	GO:0006334	nucleosome assembly	Smyd3	IMP		Mouse	PMID:23752591
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Smyd3	IMP		Mouse	PMID:23752591
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Smyd3	IMP		Mouse	PMID:23752591
Biological Process	GO:0060538	skeletal muscle organ development	smyd3	IMP	ZFIN:ZDB-MRPHLNO-110922-1	Zfish	PMID:21887258
Biological Process	GO:0060538	skeletal muscle organ development	smyd3	IMP	ZFIN:ZDB-MRPHLNO-110922-2	Zfish	PMID:21887258

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern