Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Socs1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SOCS1
- Mouse genes Socs1
- Rat genes Socs1
- Zfish genes socs1a,socs1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Socs1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	SOCS1	IPI	UniProtKB:P08069	Human	PMID:9727029
Molecular Function	GO:0019210	kinase inhibitor activity	Socs1	IDA		Mouse	PMID:9202126
Molecular Function	GO:0019210	kinase inhibitor activity	Socs1	IDA		Mouse	PMID:9889194
Molecular Function	GO:0005515	protein binding	SOCS1	IPI	UniProtKB:P04626	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	SOCS1	IPI	UniProtKB:Q15369	Human	PMID:16643902
Molecular Function	GO:0005515	protein binding	SOCS1	IPI	UniProtKB:Q04206	Human	PMID:17183367
Molecular Function	GO:0005515	protein binding	SOCS1	IPI	UniProtKB:Q15369	Human	PMID:17183367
Molecular Function	GO:0005515	protein binding	SOCS1	IPI	UniProtKB:Q8N668	Human	PMID:17183367
Molecular Function	GO:0005515	protein binding	SOCS1	IPI	UniProtKB:Q77YG1	Human	PMID:18172216
Molecular Function	GO:0005515	protein binding	SOCS1	IPI	UniProtKB:O14508\|UniProtKB:Q96GG9	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	SOCS1	IPI	UniProtKB:Q15369	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	SOCS1	IPI	UniProtKB:Q99961	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Socs1	IPI	UniProtKB:Q99PJ2	Mouse	MGI:MGI:2387897\|PMID:12163497
Molecular Function	GO:0005515	protein binding	Socs1	IPI	PR:Q62120	Mouse	PMID:9202126
Molecular Function	GO:0005515	protein binding	Socs1	IPI	PR:Q62070	Mouse	PMID:11854514
Molecular Function	GO:0005515	protein binding	Socs1	IPI	PR:P15208	Mouse	PMID:15169905
Molecular Function	GO:0019901	protein kinase binding	SOCS1	IPI	UniProtKB:O60674	Human	PMID:9727029
Cellular Component	GO:0005737	cytoplasm	Socs1	IDA		Rat	PMID:27538408\|RGD:151347179
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	SOCS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SOCS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Socs1	IDA		Rat	PMID:10707961\|RGD:151232287
Biological Process	GO:0031100	animal organ regeneration	Socs1	IEP		Rat	PMID:11867182\|RGD:2298919
Biological Process	GO:0071230	cellular response to amino acid stimulus	Socs1	IDA		Mouse	PMID:20548288
Biological Process	GO:0071345	cellular response to cytokine stimulus	Socs1	IDA		Rat	PMID:19414010\|RGD:10402041
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Socs1	IEP		Rat	PMID:21742974\|RGD:151347181
Biological Process	GO:0071407	cellular response to organic cyclic compound	Socs1	IDA		Rat	PMID:19414010\|RGD:10402041
Biological Process	GO:1905229	cellular response to thyrotropin-releasing hormone	Socs1	IEP		Rat	PMID:10707961\|RGD:151232287
Biological Process	GO:0071346	cellular response to type II interferon	Socs1	IEP		Rat	PMID:10707961\|RGD:151232287
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	Socs1	IEP		Rat	PMID:30771456\|RGD:151347421
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Socs1	IDA		Mouse	PMID:9202127
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Socs1	IDA		Mouse	PMID:9202126
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Socs1	IMP	MGI:MGI:2177057	Mouse	PMID:11606785
Biological Process	GO:0035162	embryonic hemopoiesis	socs1a	IMP	ZFIN:ZDB-MRPHLNO-120524-9	Zfish	PMID:21421851
Biological Process	GO:0045444	fat cell differentiation	Socs1	IMP		Mouse	PMID:16127460
Biological Process	GO:0030225	macrophage differentiation	SOCS1	IMP		Human	PMID:32634427
Biological Process	GO:0043377	negative regulation of CD8-positive, alpha-beta T cell differentiation	Socs1	IMP		Mouse	MGI:MGI:6140589\|PMID:24880459
Biological Process	GO:1904898	negative regulation of hepatic stellate cell proliferation	Socs1	IMP		Rat	PMID:32317960\|RGD:151347420
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Socs1	IDA		Mouse	PMID:15169905
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	SOCS1	IMP		Human	PMID:25019494
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	Socs1	IMP	MGI:MGI:2445448	Mouse	PMID:11371356
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	socs1a	IGI	ZFIN:ZDB-MRPHLNO-100427-10,ZFIN:ZDB-MRPHLNO-120524-9	Zfish	PMID:21421851
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	socs1a	IMP	ZFIN:ZDB-MRPHLNO-120524-9	Zfish	PMID:21421851
Biological Process	GO:0060336	negative regulation of type II interferon-mediated signaling pathway	socs1a	IDA		Zfish	PMID:24183820
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	SOCS1	IMP		Human	PMID:25019494
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	Socs1	IDA		Mouse	PMID:9202127
Biological Process	GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation	Socs1	IMP		Mouse	MGI:MGI:6140589\|PMID:24880459
Biological Process	GO:2000271	positive regulation of fibroblast apoptotic process	Socs1	IMP		Rat	PMID:32317960\|RGD:151347420
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	SOCS1	IMP		Human	PMID:22387553
Biological Process	GO:2000406	positive regulation of T cell migration	socs1a	IMP	ZFIN:ZDB-MRPHLNO-130214-4	Zfish	PMID:28266617
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Socs1	IDA		Mouse	PMID:11854514
Biological Process	GO:0010533	regulation of activation of Janus kinase activity	Socs1	IMP	MGI:MGI:2656917	Mouse	PMID:21606371
Biological Process	GO:0001817	regulation of cytokine production	Socs1	IMP	MGI:MGI:2656917	Mouse	PMID:21606371
Biological Process	GO:0051896	regulation of protein kinase B signaling	socs1a	IMP	ZFIN:ZDB-GENO-160519-3	Zfish	PMID:25759395
Biological Process	GO:0001932	regulation of protein phosphorylation	Socs1	IDA		Mouse	PMID:15169905
Biological Process	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	Socs1	IMP	MGI:MGI:2656917	Mouse	PMID:21606371
Biological Process	GO:0042509	regulation of tyrosine phosphorylation of STAT protein	Socs1	IMP	MGI:MGI:2656917	Mouse	PMID:21606371
Biological Process	GO:0042509	regulation of tyrosine phosphorylation of STAT protein	socs1a	IMP	ZFIN:ZDB-GENO-160519-3	Zfish	PMID:25759395
Biological Process	GO:0034097	response to cytokine	Socs1	IEP		Rat	PMID:18424750\|RGD:2298910
Biological Process	GO:0036017	response to erythropoietin	Socs1	IEP		Rat	PMID:22796671\|RGD:151347180
Biological Process	GO:0032355	response to estradiol	Socs1	IEP		Rat	PMID:18325991\|RGD:2298914
Biological Process	GO:0032868	response to insulin	socs1a	IMP	ZFIN:ZDB-GENO-160519-3	Zfish	PMID:25759395
Biological Process	GO:0032496	response to lipopolysaccharide	Socs1	IEP		Rat	PMID:18424750\|RGD:2298910
Biological Process	GO:0043434	response to peptide hormone	Socs1	IEP		Rat	PMID:18325991\|RGD:2298914
Biological Process	GO:0032570	response to progesterone	Socs1	IEP		Rat	PMID:18325991\|RGD:2298914
Biological Process	GO:0009410	response to xenobiotic stimulus	Socs1	IEP		Rat	PMID:18171911\|RGD:2298915
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	socs1a	IMP	ZFIN:ZDB-MRPHLNO-130214-4	Zfish	PMID:23300608

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.