Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SOCS2
  • Mouse genes Socs2
  • Rat genes Socs2
  • Zfish genes socs2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Socs2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005131	growth hormone receptor binding	Socs2	IPI	PR:P16882	Mouse	PMID:15690087
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	SOCS2	IPI	UniProtKB:P08069	Human	PMID:9727029
Molecular Function	GO:0005515	protein binding	SOCS2	IPI	UniProtKB:P19235	Human	PMID:11781573
Molecular Function	GO:0005515	protein binding	SOCS2	IPI	UniProtKB:Q15369	Human	PMID:16643902
Molecular Function	GO:0005515	protein binding	SOCS2	IPI	UniProtKB:Q15369	Human	PMID:19159283
Molecular Function	GO:0005515	protein binding	SOCS2	IPI	UniProtKB:Q93034	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	SOCS2	IPI	UniProtKB:O15524	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	SOCS2	IPI	UniProtKB:P10721	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	SOCS2	IPI	UniProtKB:Q93034	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SOCS2	IPI	UniProtKB:Q93034	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	SOCS2	IPI	UniProtKB:Q93034	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	SOCS2	IPI	UniProtKB:O15033	Human	PMID:31578312
Molecular Function	GO:0005515	protein binding	SOCS2	IPI	UniProtKB:O75716	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SOCS2	IPI	UniProtKB:P07947	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SOCS2	IPI	UniProtKB:P40337-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SOCS2	IPI	UniProtKB:Q93034	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Socs2	IPI	UniProtKB:P20444|UniProtKB:Q8CHG5	Mouse	MGI:MGI:6369908|PMID:31578312
Biological Process	GO:0007568	aging	Socs2	IEP		Rat	PMID:16373446|RGD:2298927
Biological Process	GO:0032870	cellular response to hormone stimulus	SOCS2	IDA		Human	PMID:12552091
Biological Process	GO:0060396	growth hormone receptor signaling pathway	SOCS2	IDA		Human	PMID:12552091
Biological Process	GO:0035556	intracellular signal transduction	Socs2	IMP		Mouse	PMID:15690087
Biological Process	GO:0007595	lactation	Socs2	IMP		Mouse	PMID:11445538
Biological Process	GO:0007595	lactation	Socs2	IGI	MGI:MGI:97763	Mouse	PMID:11445538
Biological Process	GO:0060749	mammary gland alveolus development	Socs2	IGI	MGI:MGI:97763	Mouse	PMID:11445538
Biological Process	GO:0060749	mammary gland alveolus development	Socs2	IGI	MGI:MGI:97763	Mouse	PMID:16469767
Biological Process	GO:0060749	mammary gland alveolus development	Socs2	IMP		Mouse	PMID:11445538
Biological Process	GO:0040015	negative regulation of multicellular organism growth	Socs2	IMP	MGI:MGI:1934557	Mouse	PMID:15690087
Biological Process	GO:0040015	negative regulation of multicellular organism growth	Socs2	IGI	MGI:MGI:95710	Mouse	PMID:15690087
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	Socs2	IGI	MGI:MGI:97763	Mouse	PMID:16469767
Biological Process	GO:0045666	positive regulation of neuron differentiation	Socs2	IDA		Mouse	PMID:12368809
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Socs2	IGI	MGI:MGI:97763	Mouse	PMID:16469767
Biological Process	GO:0040014	regulation of multicellular organism growth	Socs2	IMP	MGI:MGI:1856899	Mouse	PMID:11401434
Biological Process	GO:0032355	response to estradiol	SOCS2	IDA		Human	PMID:12552091
Biological Process	GO:0043434	response to peptide hormone	Socs2	IEP		Rat	PMID:11312157|RGD:634751

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern