Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Socs3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SOCS3
- Mouse genes Socs3
- Rat genes Socs3
- Zfish genes socs3a,socs3b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Socs3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035198	miRNA binding	Socs3	IDA		Mouse	PMID:30294880
Molecular Function	GO:0035198	miRNA binding	Socs3	IMP		Mouse	PMID:30294880
Molecular Function	GO:0001784	phosphotyrosine residue binding	Socs3	IMP		Mouse	MGI:MGI:5882891\|PMID:16302975
Molecular Function	GO:0005515	protein binding	SOCS3	IPI	UniProtKB:Q66K74	Human	PMID:19027008
Molecular Function	GO:0005515	protein binding	SOCS3	IPI	UniProtKB:P10721	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	SOCS3	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	SOCS3	IPI	UniProtKB:O95863	Human	PMID:25203322
Molecular Function	GO:0005515	protein binding	SOCS3	IPI	UniProtKB:I6L996	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SOCS3	IPI	UniProtKB:P07947	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SOCS3	IPI	UniProtKB:Q8N8K9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SOCS3	IPI	UniProtKB:P07947	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SOCS3	IPI	UniProtKB:P42681	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SOCS3	IPI	UniProtKB:P51451	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SOCS3	IPI	UniProtKB:Q8N8K9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Socs3	IPI	UniProtKB:Q00560	Mouse	MGI:MGI:6695675\|PMID:23454976
Molecular Function	GO:0005515	protein binding	Socs3	IPI	UniProtKB:Q15370	Mouse	MGI:MGI:4939120\|PMID:18590740
Molecular Function	GO:0005515	protein binding	Socs3	IPI	UniProtKB:Q00560	Mouse	MGI:MGI:5512848\|PMID:16905102
Molecular Function	GO:0005515	protein binding	Socs3	IPI	PR:P15208	Mouse	PMID:15169905
Molecular Function	GO:0005515	protein binding	Socs3	IPI	PR:P62869	Mouse	PMID:15601820
Molecular Function	GO:0005515	protein binding	Socs3	IPI	PR:Q9WTZ1	Mouse	PMID:15601820
Molecular Function	GO:0005515	protein binding	Socs3	IPI	PR:P83940	Mouse	PMID:15601820
Molecular Function	GO:0005515	protein binding	Socs3	IPI	PR:Q9D5V5	Mouse	PMID:15601820
Molecular Function	GO:0030292	protein tyrosine kinase inhibitor activity	SOCS3	IDA		Human	PMID:9727029
Cellular Component	GO:0005737	cytoplasm	Socs3	IDA		Rat	PMID:16125475\|RGD:1625685
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	SOCS3	IDA		Human	PMID:9727029
Cellular Component	GO:0005634	nucleus	Socs3	IDA		Rat	PMID:10707961\|RGD:151232287
Biological Process	GO:0007568	aging	Socs3	IEP		Rat	PMID:12163036\|RGD:625538
Biological Process	GO:0031100	animal organ regeneration	Socs3	IEP		Rat	PMID:11867182\|RGD:2298919
Biological Process	GO:0007420	brain development	socs3b	IMP	ZFIN:ZDB-MRPHLNO-230301-1	Zfish	PMID:34646310
Biological Process	GO:0060670	branching involved in labyrinthine layer morphogenesis	Socs3	IMP	MGI:MGI:2180861	Mouse	PMID:11481489
Biological Process	GO:0030154	cell differentiation	Socs3	IGI	MGI:MGI:96787	Mouse	PMID:15358627
Biological Process	GO:0030154	cell differentiation	Socs3	IDA		Mouse	PMID:15358627
Biological Process	GO:0008283	cell population proliferation	socs3a	IMP	ZFIN:ZDB-GENO-190515-7	Zfish	PMID:29690953
Biological Process	GO:0097398	cellular response to interleukin-17	Socs3	IDA		Mouse	PMID:30294880
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Socs3	IEP		Mouse	PMID:20439489
Biological Process	GO:1905229	cellular response to thyrotropin-releasing hormone	Socs3	IEP		Rat	PMID:10707961\|RGD:151232287
Biological Process	GO:0071346	cellular response to type II interferon	Socs3	IEP		Rat	PMID:10707961\|RGD:151232287
Biological Process	GO:0070365	hepatocyte differentiation	socs3a	IMP	ZFIN:ZDB-GENO-190515-7	Zfish	PMID:29690953
Biological Process	GO:0035556	intracellular signal transduction	Socs3	IDA		Rat	PMID:12239110\|RGD:625667
Biological Process	GO:0048681	negative regulation of axon regeneration	socs3a	IMP	ZFIN:ZDB-MRPHLNO-140620-2	Zfish	PMID:24523552
Biological Process	GO:0048681	negative regulation of axon regeneration	socs3a	IMP	ZFIN:ZDB-MRPHLNO-080208-1	Zfish	PMID:24523552
Biological Process	GO:0050728	negative regulation of inflammatory response	Socs3	IGI	MGI:MGI:1933533	Mouse	PMID:20530874
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Socs3	IDA		Mouse	PMID:15169905
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	SOCS3	IMP		Human	PMID:25019494
Biological Process	GO:0009968	negative regulation of signal transduction	Socs3	IGI	MGI:MGI:96787	Mouse	PMID:15358627
Biological Process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	SOCS3	IMP		Human	PMID:25019494
Biological Process	GO:0060674	placenta blood vessel development	Socs3	IMP	MGI:MGI:2180861	Mouse	PMID:11481489
Biological Process	GO:0045597	positive regulation of cell differentiation	Socs3	IDA		Mouse	PMID:15358627
Biological Process	GO:0045597	positive regulation of cell differentiation	Socs3	IGI	MGI:MGI:96787	Mouse	PMID:15358627
Biological Process	GO:0035677	posterior lateral line neuromast hair cell development	socs3a	IMP	ZFIN:ZDB-MRPHLNO-120813-1	Zfish	PMID:22855815
Biological Process	GO:0035677	posterior lateral line neuromast hair cell development	socs3a	IMP	ZFIN:ZDB-MRPHLNO-120813-2	Zfish	PMID:22855815
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Socs3	IDA		Rat	PMID:12239110\|RGD:625667
Biological Process	GO:0031099	regeneration	socs3a	IGI	ZFIN:ZDB-GENE-980526-68	Zfish	PMID:22855815
Biological Process	GO:0001932	regulation of protein phosphorylation	Socs3	IDA		Mouse	PMID:15169905
Biological Process	GO:0009617	response to bacterium	Socs3	IEP		Rat	PMID:17405912\|RGD:1625683
Biological Process	GO:0034097	response to cytokine	Socs3	IEP		Rat	PMID:18424750\|RGD:2298910
Biological Process	GO:0032355	response to estradiol	Socs3	IEP		Rat	PMID:18325991\|RGD:2298914
Biological Process	GO:0032094	response to food	Socs3	IEP		Rat	PMID:12163036\|RGD:625538
Biological Process	GO:0010332	response to gamma radiation	Socs3	IEP		Rat	PMID:14751512\|RGD:1625440
Biological Process	GO:0010332	response to gamma radiation	Socs3	IEP		Rat	PMID:16937495\|RGD:2298916
Biological Process	GO:0051384	response to glucocorticoid	Socs3	IEP		Rat	PMID:10998044\|RGD:2313791
Biological Process	GO:0009408	response to heat	Socs3	IEP		Rat	PMID:12392283\|RGD:730264
Biological Process	GO:0009725	response to hormone	Socs3	IEP		Rat	PMID:11133009\|RGD:2303125
Biological Process	GO:0001666	response to hypoxia	Socs3	IEP		Rat	PMID:16125475\|RGD:1625685
Biological Process	GO:0032868	response to insulin	Socs3	IEP		Rat	PMID:15192048\|RGD:1625687
Biological Process	GO:0032496	response to lipopolysaccharide	Socs3	IEP		Rat	PMID:18424750\|RGD:2298910
Biological Process	GO:0014070	response to organic cyclic compound	Socs3	IEP		Rat	PMID:12239110\|RGD:625667
Biological Process	GO:0043434	response to peptide hormone	Socs3	IEP		Rat	PMID:12107179\|RGD:632386
Biological Process	GO:0032570	response to progesterone	Socs3	IEP		Rat	PMID:18325991\|RGD:2298914
Biological Process	GO:0009410	response to xenobiotic stimulus	Socs3	IEP		Rat	PMID:17394460\|RGD:1625675
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	socs3a	IMP	ZFIN:ZDB-MRPHLNO-130214-3	Zfish	PMID:23300608
Biological Process	GO:0007165	signal transduction	Socs3	IGI	MGI:MGI:96787	Mouse	PMID:15358627
Biological Process	GO:0007165	signal transduction	Socs3	IDA		Rat	PMID:12239110\|RGD:625667

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.