Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SOD2
  • Mouse genes Sod2
  • Rat genes Sod2
  • Zfish genes sod2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sod2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Sod2	IDA		Rat	PMID:19228881|RGD:2306615
Molecular Function	GO:0019899	enzyme binding	Sod2	IPI	RGD:1308374	Rat	PMID:24505357|RGD:8158103
Molecular Function	GO:0042802	identical protein binding	SOD2	IPI	UniProtKB:P04179	Human	PMID:19822147
Molecular Function	GO:0042802	identical protein binding	SOD2	IPI	UniProtKB:P04179	Human	PMID:21988832
Molecular Function	GO:0042802	identical protein binding	Sod2	IPI	RGD:3732	Rat	PMID:19384983|RGD:2317389
Molecular Function	GO:0030145	manganese ion binding	SOD2	IDA		Human	PMID:19265433
Molecular Function	GO:0030145	manganese ion binding	Sod2	IDA		Rat	PMID:19384983|RGD:2317389
Molecular Function	GO:0016491	oxidoreductase activity	Sod2	IMP		Mouse	MGI:MGI:3505659|PMID:15205258
Molecular Function	GO:0019825	oxygen binding	Sod2	IDA		Rat	PMID:12107766|RGD:2291939
Molecular Function	GO:0019825	oxygen binding	Sod2	IDA		Rat	PMID:15642720|RGD:2291946
Molecular Function	GO:0005515	protein binding	SOD2	IPI	UniProtKB:Q8NHQ1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Sod2	IPI	UniProtKB:P02340|UniProtKB:P54099	Mouse	MGI:MGI:5448514|PMID:21909133
Molecular Function	GO:0004784	superoxide dismutase activity	SOD2	IDA		Human	PMID:12551919
Molecular Function	GO:0004784	superoxide dismutase activity	SOD2	IDA		Human	PMID:14980699
Molecular Function	GO:0004784	superoxide dismutase activity	SOD2	IDA		Human	PMID:19265433
Molecular Function	GO:0004784	superoxide dismutase activity	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:15182862
Molecular Function	GO:0004784	superoxide dismutase activity	Sod2	IDA		Mouse	PMID:9651187
Molecular Function	GO:0004784	superoxide dismutase activity	Sod2	IDA		Mouse	PMID:7333654
Molecular Function	GO:0004784	superoxide dismutase activity	Sod2	IDA		Mouse	PMID:18218638
Molecular Function	GO:0004784	superoxide dismutase activity	Sod2	IMP	MGI:MGI:2447406,MGI:MGI:2665300	Mouse	PMID:23195678
Molecular Function	GO:0004784	superoxide dismutase activity	Sod2	IMP	MGI:MGI:2176435,MGI:MGI:2447406	Mouse	PMID:12176043
Molecular Function	GO:0004784	superoxide dismutase activity	Sod2	IDA		Mouse	PMID:12646716
Molecular Function	GO:0004784	superoxide dismutase activity	Sod2	IDA		Rat	PMID:12107766|RGD:2291939
Molecular Function	GO:0004784	superoxide dismutase activity	Sod2	IDA		Rat	PMID:15642720|RGD:2291946
Molecular Function	GO:0004784	superoxide dismutase activity	Sod2	IDA		Rat	PMID:15642785|RGD:1582451
Molecular Function	GO:0004784	superoxide dismutase activity	sod2	IDA		Zfish	PMID:19501168
Cellular Component	GO:0005737	cytoplasm	Sod2	IDA		Rat	PMID:16372329|RGD:1581086
Cellular Component	GO:0070062	extracellular exosome	SOD2	HDA		Human	PMID:23533145
Cellular Component	GO:0005743	mitochondrial inner membrane	Sod2	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005759	mitochondrial matrix	SOD2	IDA		Human	PMID:23168492
Cellular Component	GO:0042645	mitochondrial nucleoid	Sod2	IDA		Rat	PMID:19228881|RGD:2306615
Cellular Component	GO:0005739	mitochondrion	SOD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	SOD2	IDA		Human	PMID:12551919
Cellular Component	GO:0005739	mitochondrion	Sod2	IDA		Mouse	PMID:17597094
Cellular Component	GO:0005739	mitochondrion	Sod2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Sod2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Sod2	IDA		Mouse	PMID:16103131
Cellular Component	GO:0005739	mitochondrion	Sod2	IDA		Mouse	PMID:17923681
Cellular Component	GO:0005739	mitochondrion	Sod2	IDA		Mouse	PMID:11583975
Cellular Component	GO:0005739	mitochondrion	Sod2	IDA		Mouse	PMID:12931191
Cellular Component	GO:0005739	mitochondrion	Sod2	IDA		Mouse	PMID:22474353
Cellular Component	GO:0005739	mitochondrion	Sod2	IDA		Mouse	PMID:24191052
Cellular Component	GO:0005739	mitochondrion	Sod2	IDA		Rat	PMID:12107766|RGD:2291939
Cellular Component	GO:0005739	mitochondrion	Sod2	IDA		Rat	PMID:15642720|RGD:2291946
Cellular Component	GO:0005739	mitochondrion	Sod2	IDA		Rat	PMID:15642785|RGD:1582451
Cellular Component	GO:0043209	myelin sheath	Sod2	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Biological Process	GO:0003069	acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:16873728
Biological Process	GO:0003069	acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure	Sod2	IMP	MGI:MGI:1857129	Mouse	PMID:16873728
Biological Process	GO:0007568	aging	Sod2	IEP		Rat	PMID:16304208|RGD:1625691
Biological Process	GO:0008637	apoptotic mitochondrial changes	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:11226230
Biological Process	GO:0071361	cellular response to ethanol	Sod2	IEP		Rat	PMID:19703426|RGD:2317384
Biological Process	GO:0034599	cellular response to oxidative stress	SOD2	IMP		Human	PMID:14980699
Biological Process	GO:0003032	detection of oxygen	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:11156968
Biological Process	GO:0048773	erythrophore differentiation	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:15205258
Biological Process	GO:0006749	glutathione metabolic process	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:10049502
Biological Process	GO:0007507	heart development	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:7493016
Biological Process	GO:0030097	hemopoiesis	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:8790408
Biological Process	GO:0030097	hemopoiesis	Sod2	IMP		Mouse	PMID:16219542
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	Sod2	IDA		Rat	PMID:15642720|RGD:2291946
Biological Process	GO:0042743	hydrogen peroxide metabolic process	Sod2	IMP		Rat	PMID:16716903|RGD:1580833
Biological Process	GO:0045087	innate immune response	sod2	IMP	ZFIN:ZDB-MRPHLNO-150428-3	Zfish	PMID:25385799
Biological Process	GO:0032364	intracellular oxygen homeostasis	SOD2	IMP		Human	PMID:16179351
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:15642323
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:15642323
Biological Process	GO:0001889	liver development	Sod2	IMP	MGI:MGI:2177602,MGI:MGI:2447406	Mouse	PMID:17367743
Biological Process	GO:0007626	locomotory behavior	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:8790408
Biological Process	GO:0007005	mitochondrion organization	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:15205258
Biological Process	GO:0007005	mitochondrion organization	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:8790408
Biological Process	GO:0007005	mitochondrion organization	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:11527927
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:15205258
Biological Process	GO:0043066	negative regulation of apoptotic process	Sod2	IMP		Rat	PMID:11961082|RGD:1581094
Biological Process	GO:0008285	negative regulation of cell population proliferation	SOD2	IMP		Human	PMID:16179351
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Sod2	IMP		Mouse	PMID:16219542
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Sod2	IDA		Mouse	PMID:18218638
Biological Process	GO:1902631	negative regulation of membrane hyperpolarization	Sod2	IMP		Rat	PMID:20529999|RGD:27095884
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	SOD2	IGI		Human	PMID:17251466
Biological Process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	SOD2	IMP		Human	PMID:12551919
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	SOD2	IDA		Human	PMID:27021683
Biological Process	GO:0048666	neuron development	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:8790408
Biological Process	GO:0001780	neutrophil homeostasis	sod2	IMP	ZFIN:ZDB-MRPHLNO-150428-3	Zfish	PMID:25385799
Biological Process	GO:0030335	positive regulation of cell migration	SOD2	IMP		Human	PMID:20489163
Biological Process	GO:0010729	positive regulation of hydrogen peroxide biosynthetic process	Sod2	IMP		Rat	PMID:20529999|RGD:27095884
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:15637112
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	SOD2	IDA		Human	PMID:27021683
Biological Process	GO:1905932	positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching	SOD2	IDA		Human	PMID:27021683
Biological Process	GO:0009791	post-embryonic development	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:7493016
Biological Process	GO:0009791	post-embryonic development	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:8790408
Biological Process	GO:0051289	protein homotetramerization	SOD2	IPI	UniProtKB:P04179	Human	PMID:19265433
Biological Process	GO:0008217	regulation of blood pressure	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:17023572
Biological Process	GO:0050790	regulation of catalytic activity	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:9927656
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	Sod2	IMP	MGI:MGI:2177602,MGI:MGI:2447406	Mouse	PMID:17367743
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	SOD2	IMP		Human	PMID:9393747
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Sod2	IDA		Mouse	PMID:17670746
Biological Process	GO:0001836	release of cytochrome c from mitochondria	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:10212301
Biological Process	GO:0001836	release of cytochrome c from mitochondria	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:15642323
Biological Process	GO:0019430	removal of superoxide radicals	SOD2	IMP		Human	PMID:16179351
Biological Process	GO:0019430	removal of superoxide radicals	Sod2	IMP	MGI:MGI:1857129	Mouse	PMID:16873728
Biological Process	GO:0019430	removal of superoxide radicals	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:16873728
Biological Process	GO:0019430	removal of superoxide radicals	Sod2	IDA		Rat	PMID:12107766|RGD:2291939
Biological Process	GO:0019430	removal of superoxide radicals	Sod2	IDA		Rat	PMID:15642720|RGD:2291946
Biological Process	GO:0019430	removal of superoxide radicals	Sod2	IDA		Rat	PMID:19439219|RGD:2317387
Biological Process	GO:0019430	removal of superoxide radicals	sod2	IMP	ZFIN:ZDB-MRPHLNO-150428-3	Zfish	PMID:25385799
Biological Process	GO:0022904	respiratory electron transport chain	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:19478076
Biological Process	GO:0022904	respiratory electron transport chain	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:11226230
Biological Process	GO:0014823	response to activity	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:15781740
Biological Process	GO:0014823	response to activity	Sod2	IEP		Rat	PMID:19297546|RGD:2317391
Biological Process	GO:0048678	response to axon injury	Sod2	IMP	MGI:MGI:2447406,MGI:MGI:2679331	Mouse	PMID:16677818
Biological Process	GO:0046686	response to cadmium ion	Sod2	IEP		Rat	PMID:20107868|RGD:2317377
Biological Process	GO:0046686	response to cadmium ion	sod2	IEP		Zfish	PMID:16799861
Biological Process	GO:0009409	response to cold	Sod2	IEP		Rat	PMID:20020182|RGD:2317380
Biological Process	GO:0051602	response to electrical stimulus	Sod2	IEP		Rat	PMID:17962976|RGD:2317396
Biological Process	GO:0010332	response to gamma radiation	Sod2	IGI	MGI:MGI:98352	Mouse	PMID:15182862
Biological Process	GO:0010332	response to gamma radiation	Sod2	IGI	MGI:MGI:104887	Mouse	PMID:15182862
Biological Process	GO:0042542	response to hydrogen peroxide	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:15642323
Biological Process	GO:0042542	response to hydrogen peroxide	Sod2	IEP		Rat	PMID:19917063|RGD:2317381
Biological Process	GO:0055093	response to hyperoxia	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:11796207
Biological Process	GO:0001666	response to hypoxia	Sod2	IEP		Rat	PMID:16911942|RGD:1625690
Biological Process	GO:0035902	response to immobilization stress	Sod2	IEP		Rat	PMID:20020182|RGD:2317380
Biological Process	GO:0035900	response to isolation stress	Sod2	IEP		Rat	PMID:20020182|RGD:2317380
Biological Process	GO:0033591	response to L-ascorbic acid	Sod2	IEP		Rat	PMID:20122981|RGD:2317376
Biological Process	GO:0032496	response to lipopolysaccharide	Sod2	IEP		Rat	PMID:17804075|RGD:2317399
Biological Process	GO:0071000	response to magnetism	Sod2	IEP		Rat	PMID:20037191|RGD:2317379
Biological Process	GO:0010042	response to manganese ion	Sod2	IEP		Rat	PMID:17920449|RGD:2317398
Biological Process	GO:0051597	response to methylmercury	sod2	IDA		Zfish	PMID:15984772
Biological Process	GO:0031667	response to nutrient levels	Sod2	IDA		Rat	PMID:12067840|RGD:628320
Biological Process	GO:0006979	response to oxidative stress	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:19478076
Biological Process	GO:0006979	response to oxidative stress	Sod2	IGI	MGI:MGI:109169	Mouse	PMID:17322295
Biological Process	GO:0006979	response to oxidative stress	Sod2	IGI	MGI:MGI:98352	Mouse	PMID:15182862
Biological Process	GO:0006979	response to oxidative stress	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:15182862
Biological Process	GO:0006979	response to oxidative stress	Sod2	IGI	MGI:MGI:107207	Mouse	PMID:19478076
Biological Process	GO:0006979	response to oxidative stress	Sod2	IGI	MGI:MGI:104887	Mouse	PMID:15182862
Biological Process	GO:0006979	response to oxidative stress	Sod2	IEP		Rat	PMID:15485085|RGD:1581091
Biological Process	GO:0009314	response to radiation	Sod2	IEP		Rat	PMID:22780102|RGD:8158084
Biological Process	GO:0000302	response to reactive oxygen species	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:15205258
Biological Process	GO:0000302	response to reactive oxygen species	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:17145560
Biological Process	GO:0000302	response to reactive oxygen species	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:9462746
Biological Process	GO:0000302	response to reactive oxygen species	Sod2	IMP		Mouse	PMID:16219542
Biological Process	GO:0000302	response to reactive oxygen species	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:9927656
Biological Process	GO:0010269	response to selenium ion	Sod2	IEP		Rat	PMID:17804075|RGD:2317399
Biological Process	GO:0034021	response to silicon dioxide	Sod2	IEP		Rat	PMID:17575405|RGD:2317404
Biological Process	GO:0000303	response to superoxide	SOD2	IMP		Human	PMID:16179351
Biological Process	GO:0000303	response to superoxide	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:11156968
Biological Process	GO:0000303	response to superoxide	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:15642323
Biological Process	GO:0009410	response to xenobiotic stimulus	Sod2	IDA		Rat	PMID:15959853|RGD:1625692
Biological Process	GO:0010043	response to zinc ion	Sod2	IEP		Rat	PMID:20128680|RGD:2317375
Biological Process	GO:0042554	superoxide anion generation	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:15781740
Biological Process	GO:0042554	superoxide anion generation	Sod2	IMP	MGI:MGI:2447406,MGI:MGI:2679331	Mouse	PMID:16677818
Biological Process	GO:0042554	superoxide anion generation	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:10212301
Biological Process	GO:0006801	superoxide metabolic process	SOD2	IDA		Human	PMID:12551919
Biological Process	GO:0006801	superoxide metabolic process	SOD2	IDA		Human	PMID:14980699
Biological Process	GO:0006801	superoxide metabolic process	Sod2	IMP	MGI:MGI:1857344	Mouse	PMID:10049502
Biological Process	GO:0006801	superoxide metabolic process	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:15637112
Biological Process	GO:0006801	superoxide metabolic process	Sod2	IMP	MGI:MGI:2176435,MGI:MGI:2447406	Mouse	PMID:12176043
Biological Process	GO:0042311	vasodilation	Sod2	IMP	MGI:MGI:1857480	Mouse	PMID:15637112

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern